| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| A B M Grudell, M Camilleri, P Carlson, H Gorman, M Ryks, D Burton, K Baxter, A R Zinsmeiste. An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 3. 2008-03-31. PMID:17971028. |
genetic variations evaluated were: alpha(2a) adrenergic (c-1291g), alpha(2c) (del 332-325), 5-ht transporter (slc6a4) and gnbeta3 (c825t). |
2008-03-31 |
2023-08-12 |
human |
| H J Kim, M Camilleri, P J Carlson, F Cremonini, I Ferber, D Stephens, S McKinzie, A R Zinsmeister, R Urruti. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut. vol 53. issue 6. 2004-07-12. PMID:15138209. |
our aims were: (1) to compare the prevalence of polymorphisms of alpha 2 (alpha(2)) adrenoceptors, norepinephrine transporter, and serotonin transporter protein (soluble carrier protein member 4 (slc6a4)) promoter in patients with lower functional gastrointestinal disorders (fgid) and in healthy controls; and (2) to test associations of these genetic variations with symptoms of ibs and high somatic symptom scores. |
2004-07-12 |
2023-08-12 |
Not clear |