| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E P Bruzzone, B Ozenne, P M Fisher, G Ortega, P S Jensen, V H Dam, C Svarer, G M Knudsen, K P Lesch, V G Frokjae. No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state. Clinical epigenetics. vol 16. issue 1. 2024-05-28. PMID:38802956. |
here, we evaluated the association between whole-blood-derived methylation of four cpg sites in the serotonin transporter (slc6a4) and six cpg sites of the tryptophan hydroxylase 2 (tph2) gene and in-vivo brain levels of serotonin transporter (5-htt) and serotonin 4 receptor (5-ht |
2024-05-28 |
2024-06-03 |
Not clear |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we found that tph2, htr1a and slc6a4 mrna expression were increased in subregions of the dorsal raphe nucleus in the hfd, relative to control diet. |
2024-05-05 |
2024-05-08 |
rat |
| Emmeline R I Howarth, Isabelle D Szott, Claire L Witham, Craig S Wilding, Emily J Bethel. Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta). PloS one. vol 18. issue 8. 2023-08-02. PMID:37531334. |
for four loci the variants genotyped were length polymorphisms (slc6a4 5-hydroxytryptamine transporter length-polymorphic repeat (5-httlpr), slc6a4 stin polymorphism, tryptophan 5-hydroxylase 2 (tph2) and monoamine oxidase a (maoa)) whilst for the other five (5-hydroxytryptamine receptor 2a (htr2a), dopamine receptor d4 (drd4), oxytocin receptor (oxtr), arginine vasopressin receptor 1a (avpr1a), opioid receptor mu(μ) 1 (oprm1)) snps were analysed. |
2023-08-02 |
2023-08-14 |
monkey |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
variations like single nucleotide polymorphisms (snps) in the genes for tryptophan 5-hydroxylase (tph2), the serotonin transporter (slc6a4), the serotonin receptor (htr2a), and the oxytocin receptor (oxtr) are associated with behavioral phenotype in humans. |
2021-11-09 |
2023-08-13 |
Not clear |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
using ewes from the university of western australia temperament flock, which has been selected on emotional reactivity for more than 20 generations, eight snps (rs107856757, rs107856818, rs107856856 and rs107857156 in tph2, rs20917091 in slc6a4, rs17196799 and rs17193181 in htr2a, and rs17664565 in oxtr) were found to be distributed differently between calm and nervous sheep. |
2021-11-09 |
2023-08-13 |
Not clear |
| Stefania Zampatti, Michele Ragazzo, Carlo Fabrizio, Andrea Termine, Giulia Campoli, Valerio Caputo, Claudia Strafella, Raffaella Cascella, Carlo Caltagirone, Emiliano Giardin. Genetic Variants Allegedly Linked to Antisocial Behaviour Are Equally Distributed Across Different Populations. Journal of personalized medicine. vol 11. issue 3. 2021-04-13. PMID:33809805. |
in particular, allelic variants in slc6a4, maoa, drd4, and drd2 showed statistical associations with major depressive disorder, antisocial behaviour, schizophrenia, and bipolar disorder; bdnf polymorphic variants were associated with depressive, bipolar, and schizophrenia diseases, and tph2 variants were found both in people with unipolar depression and in children with attention deficit-hyperactivity disorder (adhd). |
2021-04-13 |
2023-08-13 |
human |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
for example, maternal separation increased slc6a4 mrna expression in the dorsal part of the dorsal raphe nucleus in tph2 heterozygous mice, but not in wild-type or knockout mice. |
2020-09-14 |
2023-08-13 |
mouse |
| James E Hassell, James H Fox, Mathew R Arnold, Philip H Siebler, Margaret W Lieb, Dominic Schmidt, Emma J Spratt, Tessa M Smith, Kadi T Nguyen, Chloé A Gates, Kaley S Holmes, K'loni S Schnabel, Kelsey M Loupy, Maike Erber, Christopher A Lowr. Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175996. |
rats were euthanized on day 21 and brain tissue was sectioned for analysis of tph2, htr1a, slc6a4, slc22a3, and crhr2 mrna expression throughout the brainstem dorsal and median raphe nuclei. |
2020-08-04 |
2023-08-13 |
rat |
| Bojan Mirkovic, David Cohen, Claudine Laurent, Malaika Lasfar, Christophe Marguet, Prsicille Gerardi. A case-control association study of 12 candidate genes and attempted suicide in French adolescents. International journal of adolescent medicine and health. vol 32. issue 1. 2020-04-22. PMID:28902619. |
we performed analysis on 22 single nucleotide polymorphisms (snps) in 12 genes (comt, crhr1, fkbp5, slc6a4, htr1b, htr2a, tph1, tph2, bdnf, ntrk2, nos1 and il28ra) for association with suicide attempt, hopelessness and impulsivity in an independent sample, composed of 98 adolescent suicide attempters who required hospitalization based on emergency assessments, and 150 healthy volunteers. |
2020-04-22 |
2023-08-13 |
human |
| Maria Teresa Plana, Teresa Torres, Natalia Rodríguez, Daniel Boloc, Patricia Gassó, Elena Moreno, Amalia Lafuente, Josefina Castro-Fornieles, Sergi Mas, Luisa Lazar. Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder. Psychiatry research. vol 271. 2019-04-23. PMID:30554102. |
following on from previous work by our group where we showed that early onset anorexia nervosa (an) and obsessive-compulsive disorder (ocd) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (slc6a4, 5htr2a, 5htr2c, tph2, slc18a1), in a common phenotype such as very-early age of onset. |
2019-04-23 |
2023-08-13 |
Not clear |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
genetic moderation of cocaine subjective effects by variation in the tph1, tph2, and slc6a4 serotonin genes. |
2018-07-27 |
2023-08-13 |
Not clear |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
this study investigated variants of tryptophan hydroxylase (tph)1, tph2, and slc6a4 in the moderation of the subjective effects of cocaine. |
2018-07-27 |
2023-08-13 |
Not clear |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girard. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients. Neuroscience letters. vol 656. 2018-04-05. PMID:28716530. |
we aimed to investigate functional polymorphisms in eight genes (serotonin transporter, slc6a4; receptors, 5htr1a, 1b, 5htr2a; tryptophan hydroxylase, tph1, tph2; monoamine oxidase, maoa and g protein subunit beta 3, gnb3) to investigate their predictive value for suicide. |
2018-04-05 |
2023-08-13 |
Not clear |