| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Majlen A Dilweg, Tamara A M Mocking, Pantelis Maragkoudakis, Gerard J P van Westen, Laura H Heitman, Adriaan P IJzerman, Willem Jespers, Daan van der E. Stereochemical optimization of RSC medicinal chemistry. 2024-09-30. PMID:39345718. |
stereochemical optimization of the norepinephrine transporter (net), encoded by the slc6a2 gene, is one of three key monoamine neurotransmitter transporters. |
2024-09-30 |
2024-10-02 |
Not clear |
| Wenming Ji, Anran Miao, Kai Liang, Jiameng Liu, Yuhan Qi, Yue Zhou, Xinli Duan, Jixue Sun, Lipeng Lai, Jing-Xiang W. Substrate binding and inhibition mechanism of norepinephrine transporter. Nature. 2024-08-14. PMID:39143211. |
norepinephrine transporter (net; encoded by slc6a2) reuptakes the majority of the released noradrenaline back to the presynaptic terminals, thereby affecting the synaptic noradrenaline level |
2024-08-14 |
2024-08-17 |
Not clear |
| Zhuoman Xia, Zhihong Cao, Wesley Surento, Li Zhang, Lianli Qiu, Qiang Xu, Longjiang Zhang, Lingjiang Li, Yang Cao, Yifeng Luo, Guangming Lu, Rongfeng Q. Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child. BMC psychiatry. vol 24. issue 1. 2024-01-03. PMID:38166870. |
norepinephrine transporter (net) is encoded by the slc6a2 gene and is a potential target for studying the pathogenesis of ptsd. |
2024-01-03 |
2024-01-06 |
Not clear |
| Cecilia E Villanueva, Bruno Hagenbuc. Palmitoylation of Solute Carriers. Biochemical pharmacology. 2023-07-22. PMID:37481134. |
among the best-characterized transporters are the glucose transporters glut1 (slc2a1) and glut4 (slc2a4), the three monoamine transporters norepinephrine transporter (net; slc6a2), dopamine transporter (dat; slc6a3), and serotonin transporter (sert; slc6a4), and the sodium-calcium exchanger ncx1 (slc8a1). |
2023-07-22 |
2023-08-14 |
Not clear |
| Chi-Yung Shang, Hsiang-Yuan Lin, Susan Shur-Fen Ga. The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:31595036. |
the norepinephrine transporter gene (slc6a2) and deficits in visual memory and attention were associated with attention-deficit/hyperactivity disorder (adhd). |
2021-10-28 |
2023-08-13 |
Not clear |
| Jakub P Fichna, Kinga Humińska-Lisowska, Krzysztof Safranow, Jakub G Adamczyk, Paweł Cięszczyk, Cezary Żekanowski, Mariusz Berdyńsk. Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population. Genes. vol 12. issue 6. 2021-09-21. PMID:34203885. |
rare variant in the slc6a2 encoding a norepinephrine transporter is associated with elite athletic performance in the polish population. |
2021-09-21 |
2023-08-13 |
Not clear |
| Sun-Young Kim, Han-Na Kim, Sang Won Jeon, Weon-Jeong Lim, Soo In Kim, Youn Jung Lee, Se Young Kim, Yong-Ku Ki. Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 107. 2021-08-18. PMID:33340618. |
association between genetic variants of the norepinephrine transporter gene (slc6a2) and bipolar i disorder. |
2021-08-18 |
2023-08-13 |
Not clear |
| Sun-Young Kim, Han-Na Kim, Sang Won Jeon, Weon-Jeong Lim, Soo In Kim, Youn Jung Lee, Se Young Kim, Yong-Ku Ki. Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 107. 2021-08-18. PMID:33340618. |
we aimed to investigate the associations between genetic variants of the norepinephrine transporter gene (net, also known as slc6a2) and diagnosis of bipolar i disorder. |
2021-08-18 |
2023-08-13 |
Not clear |
| Mengjiang Lu, Yan He, Meirong Gong, Qian Li, Qianqian Tang, Xuan Wang, Yaling Wang, Mengqian Yuan, Zhi Yu, Bin X. Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect of Electro-Acupuncture. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32180699. |
compared to hfd rats, ea can decrease sympathetic associated macrophage (sam) and the level of norepinephrine transporter protein (slc6a2). |
2020-09-28 |
2023-08-13 |
rat |
| Mengjiang Lu, Yan He, Meirong Gong, Qian Li, Qianqian Tang, Xuan Wang, Yaling Wang, Mengqian Yuan, Zhi Yu, Bin X. Role of Neuro-Immune Cross-Talk in the Anti-obesity Effect of Electro-Acupuncture. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32180699. |
the results of the present study indicate that ea exerts its anti-obesity effect via three mechanisms: (1) inhibition of sams and the norepinephrine transporter protein slc6a2, (2) promoting sns activity and thermogenesis, and (3) regulating immunologic balance. |
2020-09-28 |
2023-08-13 |
rat |
| Matthew J Farrar, Kristine E Kolkman, Joseph R Fetch. Features of the structure, development, and activity of the zebrafish noradrenergic system explored in new CRISPR transgenic lines. The Journal of comparative neurology. vol 526. issue 15. 2019-12-16. PMID:30070695. |
we made multiple transgenic zebrafish lines using the crispr/cas9 system to insert fluorescent reporters upstream of slc6a2, the norepinephrine transporter gene. |
2019-12-16 |
2023-08-13 |
zebrafish |
| So-Young Oh, Yong-Ku Ki. Association of norepinephrine transporter gene polymorphisms in attention-deficit/hyperactivity disorder in Korean population. Progress in neuro-psychopharmacology & biological psychiatry. 2019-11-20. PMID:27984158. |
we investigated the association of three single nucleotide polymorphisms(snp) of the norepinephrine transporter (net) gene slc6a2, t-182c (rs2242446), a-3081t (rs28386840), and g-1287a (rs5569) with the prevalence of attention-deficit/hyperactivity disorder (adhd), its clinical severity, and other disease-related characteristics in a korean population. |
2019-11-20 |
2023-08-13 |
human |
| João Paulo L F Guilherme, Marcelo Bigliassi, Antonio H Lancha Junio. Association study of SLC6A2 gene Thr99Ile variant (rs1805065) with athletic status in the Brazilian population. Gene. vol 707. 2019-06-24. PMID:31075414. |
recent evidence also indicates that norepinephrine neurotransmission can influence a series of psychophysical and psychobiological parameters related to athletic performance, and the presence of variants in the slc6a2 (solute carrier family 6 member 2) gene, which encodes the norepinephrine transporter, can be detrimental to an adequate noradrenergic signaling. |
2019-06-24 |
2023-08-13 |
Not clear |
| Nora Angyal, Erzsebet Zsofia Horvath, Zsanett Tarnok, Mara J Richman, Emese Bognar, Krisztina Lakatos, Maria Sasvari-Szekely, Zsofia Nemod. Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29374517. |
hitherto mostly the dopamine transporter gene has been studied in mph-response and only a few studies analyzed the norepinephrine transporter (net, slc6a2) gene, although mph is a potent inhibitor of both dopamine and norepinephrine transporters. |
2019-02-14 |
2023-08-13 |
Not clear |
| Misu Lee, Ninelia Minaskan, Tobias Wiedemann, Martin Irmler, Johannes Beckers, Behrooz H Yousefi, Georgios Kaissis, Rickmer Braren, Iina Laitinen, Natalia S Pellegat. Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo. Endocrine-related cancer. vol 24. issue 1. 2018-02-13. PMID:27811202. |
slc6a2, encoding the norepinephrine transporter (net), was downregulated in a dose-dependent manner by bez235 in rat pccs. |
2018-02-13 |
2023-08-13 |
human |
| Julia M Geissler, Marcel Romanos, Manfred Gerlach, Daniela Berg, Claudia Schult. No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs. Attention deficit and hyperactivity disorders. vol 9. issue 2. 2018-02-05. PMID:28176268. |
to explore the possibility of common genetic pathways within the respective pathophysiologies, nine adhd candidate single nucleotide polymorphisms (snps) in seven genes were tested for association with pd in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (snap25), the dopamine (da) transporter (slc6a3; dat1), da receptor d4 (drd4), serotonin receptor 1b (htr1b), tryptophan hydroxylase 2 (tph2), the norepinephrine transporter slc6a2 and three snps in cadherin 13 (cdh13). |
2018-02-05 |
2023-08-13 |
Not clear |
| Abdul Waheed Khan, Susan J Corcoran, Murray Esler, Assam El-Ost. Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome. Neuroscience and biobehavioral reviews. vol 74. issue Pt B. 2017-10-27. PMID:27345145. |
plasma norepinephrine (ne) is often elevated in patients with pots, resulting in consideration of dysfunction of the norepinephrine transporter (net) encoded by slc6a2 gene. |
2017-10-27 |
2023-08-13 |
Not clear |
| Rebecca Pinto, Philip Asherson, Nicholas Ilott, Celeste H M Cheung, Jonna Kunts. Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171. issue 7. 2017-09-21. PMID:27230021. |
mediation analysis suggested that ce (38%) and rtv (44%) substantially mediated the association between inattention and the t-allele of snp rs3785157 in the norepinephrine transporter gene (slc6a2) and the t-allele of snp rs7984966 in htr2a, respectively. |
2017-09-21 |
2023-08-13 |
Not clear |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
the primary objective of this study was to investigate five putatively functional variants of the norepinephrine transporter (slc6a2, net) and serotonin transporter (slc6a4, sert) genes and remission in depressed older adults treated with venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Jie-wei Luo, Xiao-rong Meng, Fang-meng Huang, Dan Hu, Xiao Yang, Xing-yu Zheng, Shi-chao Wei, Miao-miao Guo, Shi-ming Wu, Hong-yi Che. [Methylation in Promoter Region of SLC6A2 Gene in Heart Failure Patients and Its Correlation with Qi Deficiency/Blood Stasis Syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 35. issue 12. 2016-09-15. PMID:26882606. |
to explore the methylation status in promoter region of norepinephrine transporter gene (net, slc6a2) in heart failure ( hf) patients and its correlation with qi deficiency/blood stasis syndrome (qds/bss). |
2016-09-15 |
2023-08-13 |
Not clear |