| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gyan Watson Ray, Qiaoli Zeng, Phidelia Kusi, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Runmin Gu. Genetic and inflammatory factors underlying gestational diabetes mellitus: a review. Frontiers in endocrinology. vol 15. 2024-05-02. PMID:38694942. |
this review delves into the pivotal role of insulin function and the influence of genetic variants, including slc30a8, cdkal1, tcf7l2, irs1, and gck, in gdm development. |
2024-05-02 |
2024-05-04 |
Not clear |
| Ming Hu, Innah Kim, Ignasi Morán, Weicong Peng, Orien Sun, Amélie Bonnefond, Amna Khamis, Sílvia Bonàs-Guarch, Philippe Froguel, Guy A Rutte. Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 8. 2024-04-25. PMID:38661000. |
here, we show that deletion of variant-bearing enhancer regions using crispr-cas9 in human-derived endoc-βh3 cells lowers the expression of slc30a8 and several neighboring genes and improves glucose-stimulated insulin secretion. |
2024-04-25 |
2024-04-28 |
human |
| Ming Hu, Innah Kim, Ignasi Morán, Weicong Peng, Orien Sun, Amélie Bonnefond, Amna Khamis, Sílvia Bonàs-Guarch, Philippe Froguel, Guy A Rutte. Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 8. 2024-04-25. PMID:38661000. |
although eqtl or case analyses in human islets did not support the association between these additional genes and diabetes risk, the transcriptional regulator jq1 lowered the expression of multiple genes at the slc30a8 locus and enhanced stimulated insulin secretion. |
2024-04-25 |
2024-04-28 |
human |
| Zhongyue Yang, Yining E Wang, Catherine P Kirschke, Charles B Stephensen, John W Newman, Nancy L Keim, Yimeng Cai, Liping Huan. Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 77. 2023-02-24. PMID:36827808. |
effects of a genetic variant rs13266634 in the zinc transporter 8 gene (slc30a8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in u.s. adults. |
2023-02-24 |
2023-08-14 |
Not clear |
| Vojtěch Pavluch, Hana Engstová, Jitka Špačková, Petr Ježe. Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells. Scientific reports. vol 13. issue 1. 2023-01-13. PMID:36639413. |
pancreatic-β-cell-specifying transcription factor nkx6.1, indispensable for embryonic development of the pancreatic epithelium and commitment to β-cell lineage, directly controls the expression of a glucose transporter (glut2), pyruvate carboxylase (pcx), and genes for insulin processing (endoplasmic reticulum oxidoreductase-1β, ero1lb; zinc transporter-8, slc30a8). |
2023-01-13 |
2023-08-14 |
rat |
| Mark J Daniels, Maciej Jagielnicki, Mark Yeage. Structure/Function Analysis of human ZnT8 (SLC30A8): A Diabetes Risk Factor and Zinc Transporter. Current research in structural biology. vol 2. 2021-07-09. PMID:34235474. |
the human zinc transporter znt8 (slc30a8) is expressed primarily in pancreatic β-cells and plays a key function in maintaining the concentration of blood glucose through its role in insulin storage, maturation and secretion. |
2021-07-09 |
2023-08-13 |
human |
| Mehran Ahmadi, Abdolkarim Mahrooz, Saeid Abediankenari, Nasim Hayati Roodbar. Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes. Iranian journal of immunology : IJI. vol 17. issue 3. 2021-07-01. PMID:32996898. |
association of rs11558471 in slc30a8 gene with interleukin 17 serum levels and insulin resistance in iranian patients with type 2 diabetes. |
2021-07-01 |
2023-08-13 |
Not clear |
| Kristen E Syring, Karin J Bosma, Slavina B Goleva, Kritika Singh, James K Oeser, Christopher A Lopez, Eric P Skaar, Owen P McGuinness, Lea K Davis, David R Powell, Richard M O'Brie. Potential positive and negative consequences of ZnT8 inhibition. The Journal of endocrinology. vol 246. issue 2. 2021-01-25. PMID:32485672. |
both young and adult slc30a8 ko mice exhibit a delayed rise in insulin after glucose injection, but only the former exhibit increased basal insulin clearance and impaired glucose tolerance. |
2021-01-25 |
2023-08-13 |
mouse |
| Guy A Rutter, Pauline Chabosseau, Elisa A Bellomo, Wolfgang Maret, Ryan K Mitchell, David J Hodson, Antonia Solomou, Ming H. Intracellular zinc in insulin secretion and action: a determinant of diabetes risk? The Proceedings of the Nutrition Society. vol 75. issue 1. 2021-01-09. PMID:26365743. |
we discuss the effects on insulin secretion and action of deleting or over-expressing slc30a8 highly selectively in the pancreatic β-cell, and the role of zinc in insulin signalling. |
2021-01-09 |
2023-08-13 |
Not clear |
| Karin J Bosma, Kristen E Syring, James K Oeser, Jason D Lee, Richard K P Benninger, Matthew E Pamenter, Richard M O'Brie. Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species. Journal of molecular evolution. vol 87. issue 4-6. 2020-06-16. PMID:31273433. |
we show here that the slc30a8 gene is also inactivated in sheep, cows, chinchillas and naked mole rats but in all four species a histidine is retained at amino acid 10 in the b chain of insulin. |
2020-06-16 |
2023-08-13 |
rat |
| T Koblas, I Leontovyc, S Loukotová, F Saude. Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor. Folia biologica. vol 65. issue 3. 2020-03-09. PMID:31638558. |
upon the reprogramming, ipcs formed 4.6 ± 1.2 % of the total cells and expressed typical markers (insulin, glucokinase, abcc8, kcnj11, slc2a2, slc30a8) and transcription factors (pdx1, neurod1, mafa, nkx2.2, nkx6.1, pax4, pax6) needed for the proper function of pancreatic β-cells. |
2020-03-09 |
2023-08-13 |
human |
| Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A J Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L Beer, Antje Grotz, Rashmi B Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J Payne, Daniela Moralli, Soren K Thomsen, Philipp Kramer, Ioannis Spiliotis, Reshma Ramracheya, Pauline Chabosseau, Andria Theodoulou, Rebecca Cheung, Martijn van de Bunt, Jason Flannick, Maddalena Trombetta, Enzo Bonora, Claes B Wolheim, Leena Sarelin, Riccardo C Bonadonna, Patrik Rorsman, Benjamin Davies, Julia Brosnan, Mark I McCarthy, Timo Otonkoski, Jens O Lagerstedt, Guy A Rutter, Jesper Gromada, Anna L Gloyn, Tiinamaija Tuomi, Leif Groo. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nature genetics. vol 51. issue 11. 2020-01-22. PMID:31676859. |
we recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individuals matched for the genotype of a common t2d-risk allele in slc30a8, p.arg325. |
2020-01-22 |
2023-08-13 |
human |
| Kristen E Syring, Karin J Bosma, James K Oeser, Masakazu Shiota, Richard M O'Brie. The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content. Journal of molecular evolution. vol 86. issue 9. 2019-09-09. PMID:30392157. |
we hypothesize that inactivation of the slc30a8 gene led to low islet zinc content that allowed for the evolution of insulin that no longer bound zinc. |
2019-09-09 |
2023-08-13 |
mouse |
| Pauline Chabosseau, Jason Woodier, Rebecca Cheung, Guy A Rutte. Sensors for measuring subcellular zinc pools. Metallomics : integrated biometal science. vol 10. issue 2. 2019-01-28. PMID:29431830. |
thus, variants in the slc30a8 gene, encoding the vesicular/granular zinc transporter znt8, are associated with altered insulin release and increased t2d risk while the zinc importer zip12 is implicated in pulmonary hypertension. |
2019-01-28 |
2023-08-13 |
Not clear |
| Harvest F G. Genetic, Epigenetic and Biological Effects of Zinc Transporter (SLC30A8) in Type 1 and Type 2 Diabetes. Current diabetes reviews. vol 13. issue 2. 2018-05-29. PMID:26593983. |
zinc is essential for the proper storage, secretion and action of insulin, while solute carrier family 30 members (slc30a8) transports zinc from cytoplasm to insulin secretory granules in the pancreatic beta-cells. |
2018-05-29 |
2023-08-13 |
Not clear |
| Tsuyoshi Hirata, Tomomi Yoshitomi, Minoru Inoue, Yutaka Iigo, Koji Matsumoto, Kazuishi Kubota, Akira Shinagaw. Pathological and gene expression analysis of a polygenic diabetes model, NONcNZO10/LtJ mice. Gene. vol 629. 2017-08-28. PMID:28760554. |
a number of gene expression changes associated with decreased insulin secretion (possibly regulated by mir-29a/b) were observed, and zinc homeostasis (slc30a8, mt1 and mt2) or glucose metabolism (slc2a2) was suggested as being the candidate mechanism of pancreas failure in noncnzo10/ltj mice. |
2017-08-28 |
2023-08-13 |
mouse |
| Kristen E Syring, Kayla A Boortz, James K Oeser, Alessandro Ustione, Kenneth A Platt, Melanie K Shadoan, Owen P McGuinness, David W Piston, David R Powell, Richard M O'Brie. Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology. vol 157. issue 12. 2017-05-26. PMID:27754787. |
combined deletion of slc30a7 and slc30a8 unmasks a critical role for znt8 in glucose-stimulated insulin secretion. |
2017-05-26 |
2023-08-13 |
mouse |
| Kristen E Syring, Kayla A Boortz, James K Oeser, Alessandro Ustione, Kenneth A Platt, Melanie K Shadoan, Owen P McGuinness, David W Piston, David R Powell, Richard M O'Brie. Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology. vol 157. issue 12. 2017-05-26. PMID:27754787. |
slc30a8 is predominantly expressed in pancreatic islet β-cells, but surprisingly, multiple knockout mouse studies have shown little effect of slc30a8 deletion on glucose tolerance or glucose-stimulated insulin secretion (gsis). |
2017-05-26 |
2023-08-13 |
mouse |
| F J Wei, C Y Cai, P Yu, J Lv, C Ling, W T Shi, H X Jiao, B C Chang, F H Yang, Y Tian, M S Li, Y H Wang, L Zou, J M Shi, L M Chen, W D L. Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-19. PMID:26634513. |
we found that camta1, abi2, vhl, kat2b, pkhd1, esr1, tox, slc30a8, sfi1, and myh9 polymorphisms were associated with hba1c, fpg, and/or p2pg; gck, hhex, tcf7l2, kcnq1, and tbx5 polymorphisms were associated with insulin resistance-related traits; abcg2, slc2a9, and pkhd1 polymorphisms were associated with sua; camta1, vhl, kat2b, pon1, nub1, slitrk5, smad3, fto, fanca, and pcsk2 polymorphisms were associated with blood lipid traits; camta1, spag16, tox, kcnq1, acacb, and myh9 polymorphisms were associated with blood pressure; and ube2e3, spag16, slc2a9, cdkal1, cdkn2a/b, tcf7l2, smad3, and pnpla3 polymorphisms were associated with bmi (all p values <0.05). |
2016-09-19 |
2023-08-13 |
human |
| Guy A Rutter, Fabrice Chimient. SLC30A8 mutations in type 2 diabetes. Diabetologia. vol 58. issue 1. 2016-04-12. PMID:25287711. |
whereas insulin secretion from isolated islets is most often increased in mice inactivated for slc30a8, null animals usually show impaired glucose tolerance and lowered circulating insulin. |
2016-04-12 |
2023-08-13 |
mouse |