| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Chieh Liu, So-Yu Liu, Yu-Cheng Lin, Chung-Ji Liu, Kuo-Wei Chang, Shu-Chun Li. The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma. Cell death discovery. vol 10. issue 1. 2024-09-02. PMID:39223142. |
bioinformatic analysis of the cancer genome atlas (tcga)-hnscc dataset and rnaseq analysis performed on hnscc indicated that slc1a5 was the most dysregulated transporter among the seven homologous glutamate or neutral amino acid transporters in the slc1a family. |
2024-09-02 |
2024-09-05 |
Not clear |
| Xian Fu, Hongshen Wu, Changjiu Li, Gang Deng, Chao Che. YAP1 inhibits RSL3-induced castration-resistant prostate cancer cell ferroptosis by driving glutamine uptake and metabolism to GSH. Molecular and cellular biochemistry. 2023-09-29. PMID:37773303. |
in crpc, the yap1 level is high, which enters the nucleus and promotes the expressions of slc1a5 and gls1, thereby promoting cellular glutamine uptake and metabolism to generate glutamate and further synthesizing gsh, increasing gpx4 activity, improving cellular antioxidant capacity, and inhibiting cell death. |
2023-09-29 |
2023-10-07 |
Not clear |
| Mariafrancesca Scalise, Lara Console, Jessica Cosco, Lorena Pochini, Michele Galluccio, Cesare Indiver. ASCT1 and ASCT2: Brother and Sister? SLAS discovery : advancing life sciences R & D. vol 26. issue 9. 2021-11-15. PMID:34269129. |
the slc1 family includes seven members divided into two groups, namely, eaats and ascts, that share similar 3d architecture; the first one includes high-affinity glutamate transporters, and the second one includes slc1a4 and slc1a5, known as asct1 and asct2, respectively, responsible for the traffic of neutral amino acids across the cell plasma membrane. |
2021-11-15 |
2023-08-13 |
Not clear |
| Marcel Cetindis, Thorsten Biegner, Adelheid Munz, Peter Teriete, Siegmar Reinert, Martin Grim. Glutaminolysis and carcinogenesis of oral squamous cell carcinoma. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 273. issue 2. 2016-09-20. PMID:25663193. |
expression of glutaminolysis-related solute carrier family 1, member 5 (slc1a5)/neutral amino acid transporter (asct2), glutaminase (gls), and glutamate dehydrogenase (gldh) was analyzed in normal oral mucosa (n = 5), oral precursor lesions (simple hyperplasia, n = 11; squamous intraepithelial neoplasia, sin i-iii, n = 35), and oscc specimen (n = 42) by immunohistochemistry. |
2016-09-20 |
2023-08-13 |
Not clear |
| A V Morgun, N V Kuvacheva, E D Khilazheva, T E Taranushenko, A B Salmin. Expression of Glutamate and Glutamine Transporter Proteins in Neurovascular Unit Cells In Vitro. Bulletin of experimental biology and medicine. vol 159. issue 5. 2016-08-19. PMID:26459476. |
glutamine transporter protein slc1a5 and glutamate transporter protein eaat2 responsible for cell-cell communication and energetic coupling were studied using in vitro model of multicellular neurovascular unit consisting of astrocytes, neurons, and endotheliocytes under standard conditions and during chemical hypoxia in vitro. |
2016-08-19 |
2023-08-13 |
Not clear |
| Meng Lin, Bolin Zhang, Changning Yu, Jiaolong Li, Lin Zhang, Hui Sun, Feng Gao, Guanghong Zho. L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. PloS one. vol 9. issue 11. 2015-12-24. PMID:25368996. |
l-glutamate supplementation also increased the relative mrna expression of the jejunal mucosa ca(2+)-sensing receptor (car), metabotropic glutamate receptor 1 (mglur1) and metabotropic glutamate receptor 4 (mglur4), and neutral amino acid transporter b(0)-like (slc1a5) in the jejunal mucosa. |
2015-12-24 |
2023-08-13 |
Not clear |
| Sewha Kim, Do Hee Kim, Woo-Hee Jung, Ja Seung Ko. Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. Endocrine-related cancer. vol 20. issue 3. 2013-12-27. PMID:23507704. |
we generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (gls1 (gls)), glutamate dehydrogenase (gdh (h6pd)), and amino acid transporter-2 (asct2 (slc1a5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. |
2013-12-27 |
2023-08-12 |
Not clear |
| Yoshikatsu Kanai, Benjamin Clémençon, Alexandre Simonin, Michele Leuenberger, Martin Lochner, Martin Weisstanner, Matthias A Hedige. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine. vol 34. issue 2-3. 2013-09-09. PMID:23506861. |
besides glutamate transporters, the slc1 family encompasses two transporters of neutral amino acids, asct1 (slc1a4) and asct2 (slc1a5). |
2013-09-09 |
2023-08-12 |
Not clear |