All Relations between sirt1 and substantia nigra compacta
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Extraction Date |
Species |
Chitrakshi Pant, Genji Sukumar, Vidya Jyothi Alli, Surender Singh Jadav, Srihari Pabbaraja, Shasi V Kalivend. Allosteric Activation of SIRT1 by 2,4-Dihydroxy-azaflavanone Averts MPP ACS chemical neuroscience. 2024-07-29. PMID:39074306. |
allosteric activation of sirt1 by 2,4-dihydroxy-azaflavanone averts mpp parkinson's disease (pd) is a complex neurodegenerative disorder that affects dopamine neurons of the substantia nigra pars compacta (snpc), resulting in motor dysfunction. |
2024-07-29 |
2024-08-02 |
Not clear |
Yinuo Yang, Shouping Zhang, Jindong Guan, Yuhui Jiang, Jing Zhang, Lan Luo, Cheng Su. SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease. Biochimica et biophysica acta. Molecular basis of disease. 2022-02-14. PMID:35158021. |
moreover, the tyrosine hydroxylase (th) loss in the substantia nigra pars compacta (snpc) and striatum induced by mptp was also attenuated by sirt1. |
2022-02-14 |
2023-08-13 |
mouse |