All Relations between shh and Nicotine
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Soyoung Park, Ah-Young Oh, Byung-Su Hong, Yun-Jeong Shin, Hyewon Jang, Hyunghwan Seo, So-Mi Kang, Tae-Gyun Woo, Hyo-Pin Park, Jiwon Jeong, Hye-Ju Kim, Bae-Hoon Kim, Yonghoon Kwon, Bum-Joon Par. The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression. Molecular therapy. Oncology. vol 32. issue 4. 2024-10-01. PMID:39351074. |
here, we show that dx2 is induced by nicotine, the main component of smoking-related chemicals, which can stabilize the human epidermal growth factor receptor 2 (her2) protein and transcriptionally increase sonic hedgehog (shh). |
2024-10-01 |
2024-10-03 |
mouse |
Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
in our study, we explored the role of bdnf, wnt/β-catenin and shh signalling in depression and the involvement of these signalling pathways in providing an antidepressant effect by nicotine. |
2020-09-30 |
2023-08-13 |
rat |
Mohammed H Al-Wadei, Jheelam Banerjee, Hussein A N Al-Wadei, Hildegard M Schulle. Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling. European journal of cancer (Oxford, England : 1990). vol 52. 2016-05-02. PMID:26689865. |
chronic nicotine significantly increased the production of stress neurotransmitters and sonic hedgehog (shh) while inducing gli1 protein and decreasing gaba. |
2016-05-02 |
2023-08-13 |
Not clear |