| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed K Hankir, Christelle Le Fol. Central nervous system pathways targeted by amylin in the regulation of food intake. Biochimie. 2024-10-19. PMID:39426704. |
in this review, we discuss the evidence derived from preclinical studies showing that amylin and the related peptide salmon calcitonin (sct) directly or indirectly target genetically distinct neurons in the caudal hindbrain (nucleus tractus solitarius and area postrema), rostral hindbrain (lateral parabrachial nucleus), midbrain (lateral dorsal tegmentum and ventral tegmental area) and hypothalamus (arcuate nucleus and parasubthalamic nucleus) via activation of amylin and/or calcitonin receptors. |
2024-10-19 |
2024-10-22 |
Not clear |
| Sarah O K Mak, Li Zhang, Billy K C Cho. In vivo actions of SCTR/AT1aR heteromer in controlling Vp expression and release via cFos/cAMP/CREB pathway in magnocellular neurons of PVN. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 4. 2020-05-11. PMID:30702925. |
because the secretin (sct)/sctr axis is crucial to the central actions of angiotensin ii (angii) and both sct and angii are capable of triggering vasopressin (vp) release from hypothalamus, we investigated here the in vivo role of sctr-at1ar heteromer in regulating vp release in hypothalamus using transmembrane peptides as tools. |
2020-05-11 |
2023-08-13 |
Not clear |
| Li Zhang, Billy K C Cho. The central mechanisms of secretin in regulating multiple behaviors. Frontiers in endocrinology. vol 5. 2014-06-24. PMID:24904528. |
this mini-review focuses on various aspects of sct and sctr in hippocampus, hypothalamus, and cerebellum including distribution profiles, cellular functions, and behavioral phenotypes to elucidate the link between cellular mechanisms and behavioral control. |
2014-06-24 |
2023-08-13 |
Not clear |
| Vien H Y Lee, Ian P Y Lam, Hueng-Sik Choi, Billy K C Chow, Leo T O Le. The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation. PloS one. vol 7. issue 6. 2013-01-04. PMID:22761926. |
in mouse brain, errα coexpresses with sct in various osmoregulatory brain regions, including the lamina terminalis and the paraventricular nucleus of the hypothalamus, and its expression is induced by hyperosmotic and angii treatments. |
2013-01-04 |
2023-08-12 |
mouse |
| Carrie Yuen Yee Cheng, Jessica Yan Shuen Chu, Billy Kwok Chong Cho. Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 2. 2011-11-14. PMID:20927047. |
in recent years, sct and its receptor (sctr) have been identified in discrete nuclei of the hypothalamus, including the paraventricular nucleus (pvn) and the arcuate nucleus (arc). |
2011-11-14 |
2023-08-12 |
mouse |
| S Nicosia, F Guidobono, M Musanti, A Pecil. Inhibitory effects of calcitonin on adenylate cyclase activity in different rat brain areas. Life sciences. vol 39. issue 23. 1987-01-15. PMID:3023780. |
salmon calcitonin (sct) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. |
1987-01-15 |
2023-08-11 |
human |
| M Maeda-Hagiwara, H Watanab. Inhibitory effects of intrahypothalamic injection of calcitonin on TRH-stimulated gastric acid secretion in rats. Japanese journal of pharmacology. vol 39. issue 2. 1986-03-21. PMID:3936957. |
the present study indicates that pct and sct may in part suppress gastric acid secretion due to an interaction with trh in the hypothalamus. |
1986-03-21 |
2023-08-11 |
rat |
| F Sabbatini, C J Fimmel, F Pace, P H Tobler, R A Hinder, A L Blum, J A Fische. Distribution of intraventricular salmon calcitonin and suppression of gastric secretion. Digestion. vol 32. issue 4. 1986-01-06. PMID:3934017. |
these findings indicate that sct inhibits gastric acid secretion via receptors localized in the hypothalamus and in adjacent areas of the brain. |
1986-01-06 |
2023-08-11 |
mouse |
| Y Yamamoto, H Nakamuta, M Koida, J K Seyler, R C Orlowsk. Calcitonin-induced anorexia in rats: a structure-activity study by intraventricular injections. Japanese journal of pharmacology. vol 32. issue 6. 1983-04-15. PMID:7161957. |
all the more because detection of such a molecule must await development of a specific assay, the antagonistic property of the sct fragment found herein would have use for clarifying the physiological significance of the anorectic receptor which is possibly in the hypothalamus. |
1983-04-15 |
2023-08-12 |
human |
| M Koida, Y Yamamoto, H Nakamuta, J Matsuo, M Okamoto, T Morimoto, J K Seyler, R C Orlowsk. A novel effect of salmon calcitonin on in vitro Ca-uptake by rat brain hypothalamus: the regional and hormonal specificities. Japanese journal of pharmacology. vol 32. issue 6. 1983-04-15. PMID:7161972. |
it was found that salmon calcitonin-i (sct) inhibited in vitro 45ca2+-uptake by rat brain hypothalamus blocks in a dose-dependent manner. |
1983-04-15 |
2023-08-12 |
rat |