| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia-Pei Wang, Si-Qin Huang, Cheng-Lin Tang, Zhu-Xin Yang, Ming-Jiao Li, Cai Liao, Ke-Han Xin. Electroacupuncture of "Jiaji" (EX-B2) inhibits neuroinflammatory response and glial scar formation by regulating the expression of neutrophil extracellular traps in mice with spinal cord injury. Zhen ci yan jiu = Acupuncture research. vol 50. issue 2. 2025-03-09. PMID:40059047. |
electroacupuncture of "jiaji" (ex-b2) inhibits neuroinflammatory response and glial scar formation by regulating the expression of neutrophil extracellular traps in mice with spinal cord injury. |
2025-03-09 |
2025-03-12 |
mouse |
| Jia-Pei Wang, Si-Qin Huang, Cheng-Lin Tang, Zhu-Xin Yang, Ming-Jiao Li, Cai Liao, Ke-Han Xin. Electroacupuncture of "Jiaji" (EX-B2) inhibits neuroinflammatory response and glial scar formation by regulating the expression of neutrophil extracellular traps in mice with spinal cord injury. Zhen ci yan jiu = Acupuncture research. vol 50. issue 2. 2025-03-09. PMID:40059047. |
to observe the effect of electroacupuncture (ea) on neuroinflammatory response and glial scar formation via regulating expression of neutrophil extracellular traps (nets) in mice with spinal cord injury (sci). |
2025-03-09 |
2025-03-12 |
mouse |
| Camilo Ríos, Hermelinda Salgado-Ceballos, Israel Grijalva, Axayacatl Morales-Guadarrama, Araceli Diaz-Ruiz, Roberto Olayo, Juan Morales-Corona, María G Olayo, Guillermo J Cruz, Rodrigo Mondragón-Lozano, Laura Alvarez-Mejia, Carlos Orozco-Barrios, Stephanie Sánchez-Torres, Omar Fabela-Sánchez, Angélica Coyoy-Salgado, Braulio Hernández-Godínez, Alejandra Ibáñez-Contreras, Marisela Mendez-Arment. Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section. Journal of materials science. Materials in medicine. vol 36. issue 1. 2025-02-17. PMID:39961937. |
at the end of the follow-up, a thinner glial scar in the injured spinal cord was observed in the experimental nhp as well as regenerative nerve processes (neun and β-iii tubulin expression), while control nhp had a marked glial scar, large cysts and less nerve tissue at the injured zone. |
2025-02-17 |
2025-02-23 |
rat |
| Wen-Ya Shang, Ya-Feng Ren, Jing Huang, Bing Li, Xiao-Meng Huang, Zhi-Lan Zhan. [Progress of researches on acupuncture treatment of spinal cord injury by promoting axonal regeneration]. Zhen ci yan jiu = Acupuncture research. vol 50. issue 1. 2025-02-17. PMID:39961764. |
to support neuronal survival and axon growth; (2) inhibiting the expression of spinal cord myelin growth inhibitor nogo protein and oligodendrocyte myelin glycoprotein (omgp), requlating axon guide molecules sema3a and wnt family, etc., and inhibiting the formation of astryocyte scar to create a favorable local microenvironment for axon regeneration; and (3) regulating spinal phosphatase and tensin homolog deleted on chromosome ten (pten)/mammalian target of rapamycin (mtor) signaling, down-regulating ras homolog gene family member a (rhoa) / rho-associated protein kinase ii (rock ii) signaling, up-regulating mitogen-activated protein kinase kinase (mapk)/ extracellular signal-regulated kinase (erk) signaling, camp/ protein kinase a (pka) signaling, etc.. |
2025-02-17 |
2025-02-23 |
Not clear |
| Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramats. Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury. Journal of neuroinflammation. vol 22. issue 1. 2025-02-01. PMID:39891176. |
astrocytic heterogeneous nuclear ribonucleoprotein u is involved in scar formation after spinal cord injury. |
2025-02-01 |
2025-02-04 |
mouse |
| Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramats. Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury. Journal of neuroinflammation. vol 22. issue 1. 2025-02-01. PMID:39891176. |
inhibition of hnrnpu in astrocytes impairs the formation of astrocytic glial scar, motor function recovery, and neuronal regeneration after spinal cord injury (sci) in mice. |
2025-02-01 |
2025-02-04 |
mouse |
| Ermei Lu, Kecheng Zhou, Jiansen Miao, Yanlin Zhu, Jiyao Tang, Siting Du, Yanzhen Feng, Linyuan Jiang, Tianyao Jiang, Ting Huang, Ping Li, Xinjun Miao, Qi Han, Jian Xia. A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects. Journal of nanobiotechnology. vol 23. issue 1. 2025-01-05. PMID:39757205. |
recovery from spinal cord injury (sci) is often impeded by neuroinflammation, scar formation, and limited axonal regeneration. |
2025-01-05 |
2025-01-08 |
rat |
| Keitaro Ito, Munehisa Shinozaki, Shogo Hashimoto, Yusuke Saijo, Yu Suematsu, Tomoharu Tanaka, Kotaro Nishi, Hiroshi Yagi, Shinsuke Shibata, Yuko Kitagawa, Masaya Nakamura, Hideyuki Okano, Jun Kohyama, Narihito Nagosh. Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury. Scientific reports. vol 14. issue 1. 2024-12-29. PMID:39733145. |
histological effects of combined therapy involving scar resection, decellularized scaffolds, and human ipsc-ns/pcs transplantation in chronic complete spinal cord injury. |
2024-12-29 |
2024-12-31 |
human |
| Keitaro Ito, Munehisa Shinozaki, Shogo Hashimoto, Yusuke Saijo, Yu Suematsu, Tomoharu Tanaka, Kotaro Nishi, Hiroshi Yagi, Shinsuke Shibata, Yuko Kitagawa, Masaya Nakamura, Hideyuki Okano, Jun Kohyama, Narihito Nagosh. Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury. Scientific reports. vol 14. issue 1. 2024-12-29. PMID:39733145. |
chronic complete spinal cord injury (sci) is difficult to treat because of scar formation and cavitary lesions. |
2024-12-29 |
2024-12-31 |
human |
| Zhi-Qiang Wang, Rui Ran, Chun-Wei Ma, Guang-Hai Zhao, Kai-Sheng Zhou, Hai-Hong Zhan. Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats. Neurochemical research. vol 50. issue 1. 2024-11-16. PMID:39549172. |
the glial scar that forms at the site of injury after spinal cord injury (sci) is an important physical and biochemical barrier that prevents axonal regeneration and thus delays functional recovery. |
2024-11-16 |
2024-11-20 |
rat |
| Zhi-Qiang Wang, Rui Ran, Chun-Wei Ma, Guang-Hai Zhao, Kai-Sheng Zhou, Hai-Hong Zhan. Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats. Neurochemical research. vol 50. issue 1. 2024-11-16. PMID:39549172. |
to further verify the effect of knockdown of ski expression in vivo on glial scar formation and neurological function after spinal cord injury, we prepared a rat spinal cord injury model using allen's percussion method and used lentivirus as a vector to mediate the downregulation of ski in the injured spinal cord. |
2024-11-16 |
2024-11-20 |
rat |
| Zhi-Qiang Wang, Rui Ran, Chun-Wei Ma, Guang-Hai Zhao, Kai-Sheng Zhou, Hai-Hong Zhan. Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats. Neurochemical research. vol 50. issue 1. 2024-11-16. PMID:39549172. |
taken together, these results suggest that ski is able to inhibit the expression of key molecules of glial scar formation, and at the same time promotes the expression of molecules that are markers of axonal regeneration and synapse formation after spinal cord injury, making it a potential target for targeted therapy after spinal cord injury. |
2024-11-16 |
2024-11-20 |
rat |
| Fengxia Shao, Xuan Sun, Qingtong Yu, Kaili Wang, Congyong Sun, Qilong Wang, Xia Cao, Linzhi Zhang, Peng Fu, Xiufen Yang, Jiangnan Yu, Ximing Xu, Wenwen Den. Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells. International journal of biological macromolecules. vol 282. issue Pt 6. 2024-11-14. PMID:39528198. |
overexpression of glial fibrillary acidic protein (gfap) in activated astrocytes following spinal cord injury is closely associated with glial scar formation, which harms axonal regrowth. |
2024-11-14 |
2024-11-17 |
rat |
| Takuma Maeda, Takashi Agari, Takashi Komori, Keisuke Taka. A Late Complication Related to Percutaneous Implantable Leads for Spinal Cord Stimulation: Myelopathy due to Fibrous Scar Tissue. NMC case report journal. vol 11. 2024-10-31. PMID:39479470. |
a late complication related to percutaneous implantable leads for spinal cord stimulation: myelopathy due to fibrous scar tissue. |
2024-10-31 |
2024-11-02 |
Not clear |
| Ricardo Cardoso, Fellipe Soares Dos Santos Cardoso, Bruna Dos Santos Ramalho, Guilherme Dos Santos Maria, Roberta Ramos Cavalcanti, Tiago Bastos Taboada, Juliana Silva de Almeida, Ana Maria Blanco Martinez, Fernanda Martins de Almeid. Inosine Improves Functional Recovery and Cell Morphology Following Compressive Spinal Cord Injury in Mice. Neurotrauma reports. vol 5. issue 1. 2024-10-28. PMID:39464528. |
analysis of the immunoreactivity of astrocytes and evaluation of the inflammatory profile with macrophage labeling revealed that the animals of the inosine group had a lower immunoreactivity when compared to control, which suggests a reduction of the glial scar and less inflammation, respectively, leading to a more favorable microenvironment for spinal cord regeneration. |
2024-10-28 |
2024-10-30 |
mouse |
| Tianjun Chen, Li Wan, Yongchun Xiao, Ke Wang, Ping Wu, Can Li, Caiqiang Huang, Xiangge Liu, Wei Xue, Guodong Sun, Xin Ji, Hongsheng Lin, Zhisheng J. Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation. Journal of nanobiotechnology. vol 22. issue 1. 2024-10-24. PMID:39443923. |
moreover, in vivo experiments on sci mice demonstrate that ha-curnps effectively protect neuronal cells and myelin, reduce glial scar formation, thereby facilitating the repair of damaged spinal cord tissues, restoring electrical signaling at the injury site, and improving motor functions. |
2024-10-24 |
2024-10-26 |
mouse |
| Sa Feng, Linyan Liu, Yuelin Cheng, Mengmeng Zhou, Haoqiang Zhu, Xinyan Zhao, Ziyu Chen, Shunli Kan, Xuanhao Fu, Wei Hu, Rusen Zh. Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes. Frontiers in pharmacology. vol 15. 2024-10-23. PMID:39439899. |
the limited ability to regenerate axons after spinal cord injury (sci) is influenced by factors such as astrocyte activation, reactive proliferation, and glial scar formation. |
2024-10-23 |
2024-10-25 |
rat |
| Patrick C Ralph, Sung-Woo Choi, Min Jung Back, Sang Jin Le. Regenerative Medicine Approaches for the Treatment of Spinal Cord Injuries: Progress and Challenges. Acta biomaterialia. 2024-10-18. PMID:39424019. |
statement of significance: the investigation into spinal cord injury (sci) treatments focuses on reducing long-term impacts by targeting scar inhibition and enhancing regeneration through stem cells, with or without growth factors. |
2024-10-18 |
2024-10-21 |
human |
| Fangli Shan, Jianan Ye, Xinzhong Xu, Chao Liang, Yuanzhe Zhao, Jingwen Wang, Fangru Ouyang, Jianjian Li, Jianwei Lv, Zhonghan Wu, Fei Yao, Juehua Jing, Meige Zhen. Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice. Cell & bioscience. vol 14. issue 1. 2024-10-15. PMID:39407295. |
in the context of spinal cord injury (sci), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor beta (pdgfrβ |
2024-10-15 |
2024-10-18 |
mouse |
| Sipin Zhu, Qiuji Wu, Yibo Ying, Yuqin Mao, Wenjie Lu, Jie Xu, Xiong Cai, Huacheng He, Jiang W. Tissue-Adaptive BSA Hydrogel with Dual Release of PTX and bFGF Promotes Spinal Cord Injury Repair via Glial Scar Inhibition and Axon Regeneration. Small (Weinheim an der Bergstrasse, Germany). 2024-10-10. PMID:39385643. |
tissue-adaptive bsa hydrogel with dual release of ptx and bfgf promotes spinal cord injury repair via glial scar inhibition and axon regeneration. |
2024-10-10 |
2024-10-12 |
rat |