| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenrui Qu, Xiangbing Wu, Wei Wu, Ying Wang, Yan Sun, Lingxiao Deng, Melissa Walker, Chen Chen, Heqiao Dai, Qi Han, Ying Ding, Yongzhi Xia, George Smith, Rui Li, Nai-Kui Liu, Xiao-Ming X. Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075913. |
we report that when the glial scar was degraded by chondroitinase abc at the rostral and caudal lesion borders, schwann cells migrated for considerable distances in both rostral and caudal directions. |
2024-07-30 |
2024-08-02 |
human |
| Laura Maugeri, Aleksandar Jankovski, Emil Malucelli, Fabio Mangini, Jean-Michel Vandeweerd, Jacques Gilloteaux, Kathleen De Swert, Francesco Brun, Ginevra Begani Provinciali, Mauro DiNuzzo, Alberto Mittone, Alberto Bravin, Giuseppe Gigli, Federico Giove, Alessia Cedola, Charles Nicaise, Michela Fratin. Lesion extension and neuronal loss following spinal cord injury using X-ray phase-contrast tomography in mice. Journal of neurotrauma. 2022-09-08. PMID:36074949. |
moreover, glial scar borders were unevenly distributed, with rostral edges being the most extended. |
2022-09-08 |
2023-08-14 |
mouse |
| b' Andrea Bighinati, Zahra Khalajzeyqami, Vito Antonio Baldassarro, Luca Lorenzini, Maura Cescatti, Marzia Moretti, Luciana Giardino, Laura Calz\\xc3\\xa. Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury-A Data-Driven Approach. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33572341.' |
in this study, we investigated the expression profile of 100 genes encoding for ecm proteins at 1, 8 and 45 days post-injury, in the spinal cord segments rostral and caudal to the lesion and in the scar segment, in a rat model. |
2021-09-06 |
2023-08-13 |
rat |
| Michael A Thornton, Manan D Mehta, Tyler T Morad, Kaitlin L Ingraham, Rana R Khankan, Khris G Griffis, Anthony K Yeung, Hui Zhong, Roland R Roy, V Reggie Edgerton, Patricia E Phelp. Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation. Experimental neurology. vol 309. 2019-03-04. PMID:30056160. |
analyses showed that the number of serotonergic (5-ht) axons that crossed the rostral scar border and the area of neurofilament-positive axons in the injury site were both greater in oec- than fb-treated rats. |
2019-03-04 |
2023-08-13 |
rat |
| Di Wu, Michelle C Klaw, Theresa Connors, Nikolai Kholodilov, Robert E Burke, Marie-Pascale Côté, Veronica J To. Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 12. 2018-07-17. PMID:28967557. |
we combined (1) transplantation of a growth-permissive peripheral nerve graft (png) into an incomplete, cervical lesion cavity; (2) transduction of neurons rostral to the sci site to express constitutively active rheb (carheb; a ras homolog enriched in brain), a gtpase that directly activates the growth-promoting pathway mammalian target of rapamycin (mtor) via aav-carheb injection; and (3) digestion of growth-inhibitory chondroitin sulfate proteoglycans within the glial scar at the distal png interface using the bacterial enzyme chondroitinase abc (chabc). |
2018-07-17 |
2023-08-13 |
Not clear |
| Di Wu, Michelle C Klaw, Theresa Connors, Nikolai Kholodilov, Robert E Burke, Veronica J To. Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245968. |
carheb not only increased growth rostral and into the graft, it also resulted in significantly more regrowth of axons across a chabc-treated scar into caudal spinal cord. |
2015-11-05 |
2023-08-13 |
rat |
| Camelia A Danilov, Oswald Stewar. Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. Experimental neurology. vol 266. 2015-05-26. PMID:25704959. |
in addition, in the pten-deleted group, there were exuberant collaterals extending from the main tract rostral to the lesion and into and around the scar tissue at the injury site. |
2015-05-26 |
2023-08-13 |
mouse |
| Yasutaka Oda, Kenji Tani, Atsunobu Isozaki, Tomoya Haraguchi, Kazuhito Itamoto, Hiroshi Nakazawa, Yasuho Taur. Effects of polyethylene glycol administration and bone marrow stromal cell transplantation therapy in spinal cord injury mice. The Journal of veterinary medical science. vol 76. issue 3. 2014-12-08. PMID:24270802. |
in the bmsc- and bmsc+peg-groups, immunohistochemistry showed that many neuronal cells aggressively migrated toward the glial scar from the region rostral of the lesion site. |
2014-12-08 |
2023-08-12 |
mouse |
| Bingkun K Chen, Andrew M Knight, Nicolas N Madigan, LouAnn Gross, Mahrokh Dadsetan, Jarred J Nesbitt, Gemma E Rooney, Bradford L Currier, Michael J Yaszemski, Robert J Spinner, Anthony J Windeban. Comparison of polymer scaffolds in rat spinal cord: a step toward quantitative assessment of combinatorial approaches to spinal cord repair. Biomaterials. vol 32. issue 32. 2011-12-27. PMID:21803415. |
volume of scar and cyst rostral and caudal to the implanted scaffold was measured and compared. |
2011-12-27 |
2023-08-12 |
rat |
| Andres Hurtado, Heidrun Podinin, Martin Oudega, Barbara Grimp. Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord. Brain : a journal of neurology. vol 131. issue Pt 10. 2008-12-22. PMID:18765417. |
additionally, compared to control deoxyribozyme, the dnaxtas treatment resulted in a 9-fold increase in length and a 4-fold increase in density of ascending axons growing through the nerve graft and scar tissue present at the rostral spinal cord. |
2008-12-22 |
2023-08-12 |
rat |
| Andres Hurtado, Heidrun Podinin, Martin Oudega, Barbara Grimp. Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord. Brain : a journal of neurology. vol 131. issue Pt 10. 2008-12-22. PMID:18765417. |
a continuous 2-week delivery of dnaxtas near the rostral border of a peripheral nerve graft bridging the transected dorsal columns in the thoracic spinal cord resulted in an 81% decrease in xt-1 mrna, an average of 1.4-fold reduction in gag-side chains of chondroitin sulphate or heparan sulphate-pgs and 2.2-fold reduction in neurocan and brevican core proteins in scar tissue. |
2008-12-22 |
2023-08-12 |
rat |
| J T García Navia, M A Burguillos, A Ramón-Cueto, A Machado, J Cano, J L Vener. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18338800. |
time-course changes of trkb mrna expression demonstrated a robust increase in an area projecting from the rostral tip of the sn to the glial scar, which coincided with evidence of nigral dopaminergic sprouting. |
2008-08-20 |
2023-08-12 |
Not clear |
| Jian Chen, Junfang Wu, Ivayla Apostolova, Malgorzata Skup, Andrey Irintchev, Sebastian Kügler, Melitta Schachne. Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. Brain : a journal of neurology. vol 130. issue Pt 4. 2007-05-30. PMID:17438016. |
dissemination of l1-transduced cells throughout the spinal cord was wide, spanning over more than 10 mm rostral and 10 mm caudal to the lesion scar. |
2007-05-30 |
2023-08-12 |
mouse |
| Andrew M Tan, Mario Colletti, Ann T Rorai, J H Pate Skene, Joel M Levin. Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672645. |
in contrast, combining a peripheral nerve conditioning lesion with neutralizing anti-ng2 antibodies resulted in sensory axon regeneration past the glial scar and into the white matter rostral to the injury site. |
2006-05-31 |
2023-08-12 |
rat |
| Dirk Dolbeare, John D Houl. Restriction of axonal retraction and promotion of axonal regeneration by chronically injured neurons after intraspinal treatment with glial cell line-derived neurotrophic factor (GDNF). Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651811. |
one month later scar tissue was removed from the cavity by aspiration to enlarge the cavity by approximately 500 microm in a rostral direction. |
2004-01-16 |
2023-08-12 |
rat |
| Leung-Wah Yick, Pik-To Cheung, Kwok-Fai So, Wutian W. Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821386. |
the present study examined whether degradation of cspg using chondroitinase abc promoted the regeneration of cn neurons through the scar into the rostral spinal cord in neonatal and adult rats. |
2003-08-06 |
2023-08-12 |
rat |
| L Klimaschewski, N Obermüller, R Witzgal. Regulation of clusterin expression following spinal cord injury. Cell and tissue research. vol 306. issue 2. 2002-01-22. PMID:11702232. |
three weeks after trauma, clusterin mrna and protein are elevated in neurons close to the lesion site and in glial elements within scar tissue and within degenerating fiber tracts rostral and caudal to the lesion. |
2002-01-22 |
2023-08-12 |
rat |
| Y Jin, A Tessler, I Fischer, J D Houl. Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons. Neurorehabilitation and neural repair. vol 14. issue 4. 2001-11-01. PMID:11402881. |
five weeks after a cervical hemisection in adult rats, the lesion site was debrided of scar tissue and expanded in both rostral and caudal directions. |
2001-11-01 |
2023-08-12 |
rat |
| J Frisén, A Haegerstrand, K Fried, F Piehl, S Cullheim, M Rislin. Adhesive/repulsive properties in the injured spinal cord: relation to myelin phagocytosis by invading macrophages. Experimental neurology. vol 129. issue 2. 1994-12-20. PMID:7957733. |
pc12 cells failed to adhere to sections from the intact spinal cord as well as to sections taken rostral to a dorsal funiculus transection, whereas many cells adhered to the glial scar formed at the lesion. |
1994-12-20 |
2023-08-12 |
rat |
| J D Houl. Demonstration of the potential for chronically injured neurons to regenerate axons into intraspinal peripheral nerve grafts. Experimental neurology. vol 113. issue 1. 1991-07-12. PMID:2044676. |
four weeks later scar tissue lining the lesion cavity was removed prior to grafting 1 cm segments of autologous tibial nerve to the rostral and the caudal surfaces of the cavity wall. |
1991-07-12 |
2023-08-11 |
rat |