| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine Levandosky, Calina Copo. Model supports asymmetric regulation across the intercellular junction for collective cell polarization. PLoS computational biology. vol 20. issue 12. 2024-12-17. PMID:39689113. |
in a theoretical setting, we systematically searched a variety of intercellular interactions and identified that co-alignment arrangement of the polarity axes in groups of two and four cells can only be achieved with strong asymmetric regulation of rho gtpases or enhanced assembly of complementary f-actin structures across the junction. |
2024-12-17 |
2024-12-21 |
Not clear |
| Yidi Ning, Minying Zheng, Yue Zhang, Yuqi Jiao, Jiangping Wang, Shiwu Zhan. RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential. Cancer cell international. vol 24. issue 1. 2024-10-14. PMID:39402585. |
rho signaling-mediated mitotic defects and cytokinesis failure lead to asymmetric cell division, allowing cells to form polyploids to escape cytotoxicity and promote tumor recurrence and metastasis. |
2024-10-14 |
2024-10-17 |
Not clear |
| Mussie K Araya, Alemayehu A Gorf. Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases. Communications biology. vol 6. issue 1. 2023-11-03. PMID:37919400. |
we studied diverse prenylated intrinsically disordered regions (pidrs) of ras and rho family small gtpases using long timescale atomistic molecular dynamics simulations in an asymmetric model membrane of phosphatidylcholine (pc) and phosphatidylserine (ps) lipids. |
2023-11-03 |
2023-11-08 |
Not clear |
| Mussie K Araya, Alemayehu A Gorf. Conformational ensemble dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases. bioRxiv : the preprint server for biology. 2023-08-23. PMID:37609330. |
we studied diverse prenylated intrinsically disordered regions (pidrs) of ras and rho family small gtpases using long timescale atomistic molecular dynamics simulations in an asymmetric model membrane of phosphatidylcholine (pc) and phosphatidylserine (ps) lipids. |
2023-08-23 |
2023-09-07 |
Not clear |
| Helena A Crellin, Clare E Buckle. Using optogenetics to investigate the shared mechanisms of apical-basal polarity and mitosis. Cells, tissues, organs. 2023-01-04. PMID:36599311. |
these are generated using shared mechanisms, such as asymmetric protein accumulation, rho gtpase signalling, cytoskeletal reorganisation, vesicle trafficking and asymmetric phosphoinositide distribution. |
2023-01-04 |
2023-08-14 |
Not clear |
| Peishan Yi, Gohta Goshim. Rho of Plants GTPases and Cytoskeletal Elements Control Nuclear Positioning and Asymmetric Cell Division during Physcomitrella patens Branching. Current biology : CB. vol 30. issue 14. 2021-08-20. PMID:32470363. |
rho of plants gtpases and cytoskeletal elements control nuclear positioning and asymmetric cell division during physcomitrella patens branching. |
2021-08-20 |
2023-08-13 |
Not clear |
| Koji Saito, Mamiko Mori, Norito Kambara, Yasutaka Oht. FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-15. PMID:33710706. |
migrating tumor cells are characterized by a sustained front-rear asymmetry, with a front enriched in filamentous actin, which is induced by rho small gtpase rac. |
2021-07-15 |
2023-08-13 |
Not clear |
| Wakako Kawarazaki, Toshiro Fujit. Role of Rho in Salt-Sensitive Hypertension. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33803946. |
in the vascular endothelium, rho/rho kinase inhibits nitric oxide (no) production and function, and high salt amounts further augment rho activity via asymmetric dimethylarginine, an endogenous inhibitor of no synthetase, causing aberrant relaxation and increased vascular tone. |
2021-04-30 |
2023-08-13 |
human |
| Matthias C Reichert, Juozas Kupcinskas, Antje Schulz, Christoph Schramm, Susanne N Weber, Marcin Krawczyk, Christoph Jüngst, Markus Casper, Frank Grünhage, Beate Appenrodt, Vincent Zimmer, Algimantas Tamelis, Jaune I Lukosiene, Neringa Pauziene, Gediminas Kiudelis, Laimas Jonaitis, Tobias Goeser, Maciej Malinowski, Matthias Glanemann, Limas Kupcinskas, Frank Lammer. Common variation in FAM155A is associated with diverticulitis but not diverticulosis. Scientific reports. vol 10. issue 1. 2020-11-16. PMID:32015353. |
risk variants rs4662344 in rho gtpase-activating protein 15 (arhgap15), rs7609897 in collagen-like tail subunit of asymmetric acetylcholinesterase (colq) and rs67153654 in family with sequence similarity 155 a (fam155a) were genotyped in 1,332 patients. |
2020-11-16 |
2023-08-13 |
Not clear |
| Ruben Jauregui, Lawrence Chan, Jin Kyun Oh, Ahra Cho, Janet R Sparrow, Stephen H Tsan. Disease asymmetry and hyperautofluorescent ring shape in retinitis pigmentosa patients. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32098976. |
our results suggest that in patients presenting with either irregular ring shapes or asymmetric disease, emphasis should be placed in targeted gene sequencing of genes known to cause adrp, such as rho and rp1. |
2020-11-12 |
2023-08-13 |
Not clear |
| Wilbert Andrés Pérez-Pech, Alberto DE Jesús-Navarrate, Erica Demilio, Abril Anguas-Escalante, Jesper Guldberg Hanse. Marine Tardigrada from the Mexican Caribbean with the description of Styraconyx robertoi sp. nov. (Arthrotardigrada: Styraconyxidae). Zootaxa. vol 4731. issue 4. 2020-04-06. PMID:32230282. |
nov. is most similar to s. craticuliformis chang rho, 1998 and s. kristenseni renaud-mornant, 1981 by having asymmetric primary clavae but differs from s. craticuliformis mainly by the number of peduncles and from s. kristenseni mainly by the presence of a grid-like dorsal sculpture. |
2020-04-06 |
2023-08-13 |
Not clear |
| Coon, Barret. rho - omega mixing in nuclear charge asymmetry. Physical review. C, Nuclear physics. vol 36. issue 6. 2019-11-20. PMID:9954342. |
rho - omega mixing in nuclear charge asymmetry. |
2019-11-20 |
2023-08-12 |
Not clear |
| Snyder, Quin. Measuring CP asymmetry in B--> rho pi decays without ambiguities. Physical review. D, Particles and fields. vol 48. issue 5. 2019-11-20. PMID:10016451. |
measuring cp asymmetry in b--> rho pi decays without ambiguities. |
2019-11-20 |
2023-08-12 |
Not clear |
| Ewa Stypulkowski, Irfan A Asangani, Eric S Witz. The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division. Science signaling. vol 11. issue 511. 2019-05-09. PMID:29295957. |
by live-cell imaging, we showed that reciprocal interactions between apt1 and the rho family gtpase cdc42 promoted the asymmetric localization of numb and β-catenin to the plasma membrane. |
2019-05-09 |
2023-08-13 |
Not clear |
| Dan Ly, Erin Resch, George Ordiway, Stephen DiNard. Asymmetrically deployed actomyosin-based contractility generates a boundary between developing leg segments in Drosophila. Developmental biology. vol 429. issue 1. 2017-10-12. PMID:28689737. |
the boundary also exhibits an asymmetry for both myosin ii accumulation as well as one of its activators, rho kinase. |
2017-10-12 |
2023-08-13 |
drosophila_melanogaster |
| Anna Tsankova, Tri Thanh Pham, David Salvador Garcia, Fabian Otte, Clemens Cabernar. Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N. Developmental cell. vol 42. issue 2. 2017-09-25. PMID:28712722. |
cell polarity regulates biased myosin activity and dynamics during asymmetric cell division via drosophila rho kinase and protein kinase n. cell and tissue morphogenesis depends on the correct regulation of non-muscle myosin ii, but how this motor protein is spatiotemporally controlled is incompletely understood. |
2017-09-25 |
2023-08-13 |
drosophila_melanogaster |
| Arne Kutzner, Subrata Pramanik, Pok-Son Kim, Klaus Hees. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. Genomics. vol 106. issue 5. 2016-08-15. PMID:26206078. |
unique asymmetric fam72 segmental gene duplications are most likely to have occurred in conjunction with the paired genomic neighbour srgap2 (slit-robo rho gtpase activating protein), as both genes have four paralogues in humans but only one vertebra-emerging orthologue in all other species. |
2016-08-15 |
2023-08-13 |
human |
| Michelle R Facette, Yeri Park, Dena Sutimantanapi, Anding Luo, Heather N Cartwright, Bing Yang, Eric J Bennett, Anne W Sylvester, Laurie G Smit. The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize. Nature plants. vol 1. 2016-06-03. PMID:27246760. |
previous work has shown that two receptor-like kinases, pangloss2 (pan2) and pan1, and the small gtpase rho gtpase of plants (rop) promote mother cell polarity and subsequent division asymmetry in developing maize stomata. |
2016-06-03 |
2023-08-13 |
Not clear |
| Benjamin G Chan, Simon K Rocheleau, Ryan B Smit, Paul E Main. The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans. Developmental biology. vol 405. issue 2. 2015-11-17. PMID:26188247. |
contraction occurs primarily in the lateral epidermal cells during elongation while the dorsal and ventral epidermal cells have a more passive role, and localized activity of a rho gef (guanine exchange factor) could contribute to this asymmetry. |
2015-11-17 |
2023-08-13 |
caenorhabditis_elegans |
| Emilie Soares, Annie Schwartz, Marcello Nollmann, Emmanuel Margeat, Marc Boudvillai. The RNA-mediated, asymmetric ring regulatory mechanism of the transcription termination Rho helicase decrypted by time-resolved nucleotide analog interference probing (trNAIP). Nucleic acids research. vol 42. issue 14. 2014-11-04. PMID:25016524. |
the rna-mediated, asymmetric ring regulatory mechanism of the transcription termination rho helicase decrypted by time-resolved nucleotide analog interference probing (trnaip). |
2014-11-04 |
2023-08-13 |
Not clear |