| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongju Kim, Mee-Sup Yoon, Junwon Lee, Shin-Young Park, Joong-Soo Ha. Effects of phospholipase D1 inhibitory peptide on the growth and metastasis of gastric cancer cells. Molecules and cells. 2024-10-19. PMID:39426685. |
pld1, which plays a role in cancer progression, catalyzes the conversion of phosphatidylcholine into choline and phosphatidic acid through hydrolysis. |
2024-10-19 |
2024-10-22 |
Not clear |
| Usman Arshad, Marcos G Zenobi, Paula Tribulo, Charles R Staples, José E P Santo. Dose-dependent effects of rumen-protected choline on hepatic metabolism during induction of fatty liver in dry pregnant dairy cows. PloS one. vol 18. issue 10. 2023-10-05. PMID:37796906. |
feeding rpc during feed restriction increased abundance of transcripts involved in choline metabolism (chka, pld1), synthesis of apolipoprotein-b100 (apob100), and antioxidant activity (gpx3), and decreased the abundance of transcripts involved in hepatic lipogenesis (dgat2, srebf1) and acute phase response (saa3). |
2023-10-05 |
2023-10-07 |
Not clear |
| Jin-Sil Park, SeungCheon Yang, Doona Song, Ha Yeon Jeong, Sung-Min Kim, JeongWon Choi, Hye Yeon Kang, Gyoonhee Han, Do Sik Min, Mi-La Cho, Sung-Hwan Par. A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation. Immunology letters. 2023-09-18. PMID:37722567. |
phospholipase d1 (pld1), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays multiple roles in inflammation. |
2023-09-18 |
2023-10-07 |
mouse |
| Chandramouli Natarajan, Krystyn Z Bourne, Ranidhanagomathi Chandrasekaran, Charles M Cook, Balaji Krishna. Specific small-molecule inhibition of PLD1 prevents ADRD-like memory deficits by preserving dendritic spine integrity driven by amyloidogenic proteins. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108824. |
phosphatidyl choline phospholipase d (pc-pld), a lipolytic enzyme that breaks down membrane phospholipids via two isoforms - a constitutively expressed pld2 and an inducible pld1 isoform - are also involved in developmentally important signaling mechanisms that regulate synaptic function. |
2022-02-03 |
2023-08-13 |
mouse |
| Van Ngo Thai Bich, Tsunaki Hongu, Yuki Miura, Naohiro Katagiri, Norihiko Ohbayashi, Yumi Yamashita-Kanemaru, Akira Shibuya, Yuji Funakoshi, Yasunori Kanah. Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8 Scientific reports. vol 8. issue 1. 2019-10-28. PMID:29674728. |
physiological function of phospholipase d2 in anti-tumor immunity: regulation of cd8 two major phospholipase d (pld) isozymes in mammals, pld1 and pld2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. |
2019-10-28 |
2023-08-13 |
Not clear |
| Yan-Bing Zhu, Weizhen Gao, Yongbo Zhang, Feng Jia, Hai-Long Zhang, Ying-Zi Liu, Xue-Fang Sun, Yuhua Yin, Dong-Min Yi. Astrocyte-derived phosphatidic acid promotes dendritic branching. Scientific reports. vol 6. 2016-12-26. PMID:26883475. |
phospholipase d1 (pld1), which catalyzes the hydrolysis of phosphatidylcholine (pc) to generate phosphatidic acid (pa) and choline, has been implicated in the regulation of neurite outgrowth. |
2016-12-26 |
2023-08-13 |
Not clear |
| Ute Burkhardt, David Stegner, Elke Hattingen, Sandra Beyer, Bernhard Nieswandt, Jochen Klei. Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24813107. |
the phospholipases d (pld1 and 2) are signaling enzymes that catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid, a lipid second messenger involved in cell proliferation, and choline, a precursor of acetylcholine (ach). |
2014-12-23 |
2023-08-13 |
mouse |
| Kerstin Göbel, Michael K Schuhmann, Susann Pankratz, David Stegner, Alexander M Herrmann, Attila Braun, Johanna Breuer, Stefan Bittner, Tobias Ruck, Heinz Wiendl, Christoph Kleinschnitz, Bernhard Nieswandt, Sven G Meut. Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. European journal of immunology. vol 44. issue 8. 2014-11-18. PMID:24811005. |
phospholipase d1 (pld1), an enzyme that generates phosphatidic acid through hydrolysis of phosphatidylcholine and additionally yields choline as a product, has been described as regulator of the cell mobility. |
2014-11-18 |
2023-08-13 |
mouse |
| H-Y Seo, B-K Jang, Y-A Jung, E-J Lee, H-S Kim, J-H Jeon, J-G Kim, I-K Lee, M-K Kim, K-G Par. Phospholipase D1 decreases type I collagen levels in hepatic stellate cells via induction of autophagy. Biochemical and biophysical research communications. vol 449. issue 1. 2014-07-22. PMID:24802400. |
phospholipase d1 (pld1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (pa) and choline, was recently shown to modulate autophagy. |
2014-07-22 |
2023-08-13 |
human |
| Pingfu Feng, Chunfa Huan. Phospholipase D-mTOR signaling is compromised in a rat model of depression. Journal of psychiatric research. vol 47. issue 5. 2013-09-10. PMID:23421961. |
using neonatal clomipramine (cl)-treated rats as a model to elucidate the association of phospholipase d (pld) and mammalian target of rapamycin (mtor) signaling with depressive pathology, we found that the hippocampus of cl-treated rats showed significantly down-regulation of pld1 expression and attenuation of pld activity which leads to the less formation of phosphatidic acid (pa), an activator of mtor, and free choline, a potential biomarker for depression. |
2013-09-10 |
2023-08-12 |
rat |
| Maria D Cao, Mailin Döpkens, Balaji Krishnamachary, Farhad Vesuna, Mayur M Gadiya, Per E Lønning, Zaver M Bhujwalla, Ingrid S Gribbestad, Kristine Glund. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR in biomedicine. vol 25. issue 9. 2013-04-10. PMID:22279038. |
human breast cancers with malignant choline metabolite profiles consisting of low gpc and high pc levels highly co-expressed gdpd5, choline kinase alpha (chka) and phosphatidylcholine-specific phospholipase d1 (pld1), whereas cancers containing high gpc and relatively low pc levels displayed low co-expression of gdpd5, chka and pld1. |
2013-04-10 |
2023-08-12 |
human |
| Maria D Cao, Mailin Döpkens, Balaji Krishnamachary, Farhad Vesuna, Mayur M Gadiya, Per E Lønning, Zaver M Bhujwalla, Ingrid S Gribbestad, Kristine Glund. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR in biomedicine. vol 25. issue 9. 2013-04-10. PMID:22279038. |
our study identified gdpd5 as a gpc-pde that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with chka and pld1. |
2013-04-10 |
2023-08-12 |
human |
| Yoshinori Otani, Yoshihide Yamaguchi, Yumi Sato, Teiichi Furuichi, Kazuhiro Ikenaka, Hiroshi Kitani, Hiroko Bab. PLD$ is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of microglia. PloS one. vol 6. issue 11. 2012-05-08. PMID:22102906. |
unlike pld1 and pld2, pld4 exhibits no enzymatic activity for conversion of phosphatidylcholine into choline and phosphatidic acid, and its function is completely unknown. |
2012-05-08 |
2023-08-12 |
mouse |
| April L Harkins, Steven D London, Joseph W Dola. An upstream regulator and downstream target of phospholipase D1 activity during pheromone response in Saccharomyces cerevisiae. FEMS yeast research. vol 8. issue 2. 2008-05-05. PMID:18036176. |
pld1 hydrolyzes phosphatidylcholine to produce phosphatidic acid (pa) and a free choline headgroup. |
2008-05-05 |
2023-08-12 |
Not clear |
| A Sreenivas, J L Patton-Vogt, V Bruno, P Griac, S A Henr. A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642212. |
we now report that these choline and inositol excretion phenotypes are eliminated when the spo14 (pld1) gene encoding phospholipase d1 is deleted. |
1998-08-06 |
2023-08-12 |
Not clear |