| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai Duc Nguyen, Huong Huong V. Molecular mechanisms implicated in protein changes in the Alzheimer's disease human hippocampus. Mechanisms of ageing and development. 2024-03-30. PMID:38554950. |
three significant micrornas (hsa-mir-106b-5p, hsa-mir-17-5p, and hsa-mir-16-5p) and transcription factors (myt1l, pin1, and csrnp3) have been discovered to improve our understanding of the alterations in proteins within the hippocampal tissues that lead to the progression of ad. |
2024-03-30 |
2024-04-02 |
human |
| Roberta Antonelli, Roberto De Filippo, Silvia Middei, Stefka Stancheva, Beatrice Pastore, Martine Ammassari-Teule, Andrea Barberis, Enrico Cherubini, Paola Zacch. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194325. |
in electrophysiological experiments, larger nmda-mediated synaptic currents, evoked in ca1 principal cells by schaffer collateral stimulation, were detected in hippocampal slices obtained from pin1(-/-) mice compared with controls. |
2017-06-26 |
2023-08-13 |
mouse |
| Roberta Antonelli, Roberto De Filippo, Silvia Middei, Stefka Stancheva, Beatrice Pastore, Martine Ammassari-Teule, Andrea Barberis, Enrico Cherubini, Paola Zacch. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194325. |
similar results were obtained in cultured hippocampal cells expressing a psd-95 mutant unable to undergo prolyl-isomerization, thus indicating that the action of pin1 on psd-95 is critical for this effect. |
2017-06-26 |
2023-08-13 |
mouse |
| F Lattanzio, L Carboni, D Carretta, R Rimondini, S Candeletti, P Romuald. Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice. Neuroscience. vol 256. 2014-08-27. PMID:24161275. |
pin1 mrna was significantly higher in the hippocampus of apoe4 mice than in apoe3 controls, whereas lower expression was detected in the entorhinal and parietal cortices. |
2014-08-27 |
2023-08-12 |
mouse |
| F Lattanzio, L Carboni, D Carretta, R Rimondini, S Candeletti, P Romuald. Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice. Neuroscience. vol 256. 2014-08-27. PMID:24161275. |
reduced pin1 levels may increase neurofibrillary degeneration and amyloidogenic processes, while compensatory mechanisms may take place in the hippocampus to balance spatial memory deficits. |
2014-08-27 |
2023-08-12 |
mouse |
| Yan-Si Xiong, Dan-Li Wang, Lu Tan, Xiong Wang, Li-Ming Chen, Cheng-Xin Gong, Jian-Zhi Wang, Ling-Qiang Zh. Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 down-regulation. CNS & neurological disorders drug targets. vol 12. issue 3. 2014-07-11. PMID:23469846. |
in the tanglerich subregions of the hippocampus and parietal cortex in the brain of ad patients, the levels of the phosphorylationdependent protein peptidyl-prolyl cis-trans isomerase (pin1) were found to be low. |
2014-07-11 |
2023-08-12 |
Not clear |
| Elena Lonati, Anna Brambilla, Chiara Milani, Massimo Masserini, Paola Palestini, Alessandra Bulbarell. Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor. Frontiers in cellular neuroscience. vol 8. 2014-01-30. PMID:24478626. |
here we provide evidences that in rat primary hippocampal cell cultures, hif-1α degradation might be mediated by a synergic action of gsk-3β and peptidyl-prolyl cis/trans isomerase (pin1). |
2014-01-30 |
2023-08-12 |
rat |
| Ayoub Dakson, Osamu Yokota, Margaret Esiri, Eileen H Bigio, Michael Horan, Neil Pendleton, Anna Richardson, David Neary, Julie S Snowden, Andrew Robinson, Yvonne S Davidson, David M A Man. Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology. Acta neuropathologica. vol 121. issue 5. 2012-03-26. PMID:21243369. |
the hippocampal and cortical distribution of pin1 granules was distinct from that of nfts, aβ and tdp-43 pathologies, though the frequency of neurons with pin1 immunoreactivity increased with increasing nft pathology. |
2012-03-26 |
2023-08-12 |
Not clear |
| Kutay Deniz Atabay, Arzu Karaba. Pin1 inhibition activates cyclin D and produces neurodegenerative pathology. Journal of neurochemistry. vol 120. issue 3. 2012-02-24. PMID:21443524. |
here, we show that inhibition of pin1 by its selective inhibitor juglone leads to up-regulation of cyclind1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons. |
2012-02-24 |
2023-08-12 |
rat |
| Huiling Wang, Keli Dong, Guangcheng Li, Xianwen Peng, Hong Zh. [Effect of yizhi jiannao granules on the expression of Pin1 and HMGB1 mRNA in the hippocampus of SAMP8 mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 34. issue 1. 2011-04-04. PMID:19197130. |
[effect of yizhi jiannao granules on the expression of pin1 and hmgb1 mrna in the hippocampus of samp8 mice]. |
2011-04-04 |
2023-08-12 |
mouse |
| Huiling Wang, Keli Dong, Guangcheng Li, Xianwen Peng, Hong Zh. [Effect of yizhi jiannao granules on the expression of Pin1 and HMGB1 mRNA in the hippocampus of SAMP8 mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 34. issue 1. 2011-04-04. PMID:19197130. |
to investigate the effect of yizhi jiannao granule concentration fluid (ycf) on the expression of peptidyl-prolyl-cis-trans isomerase a (pin1) and high mobility group box 1 (hmgb1) mrna in the hippocampus of senescence accelerated mice senile-prone8(samp8). |
2011-04-04 |
2023-08-12 |
mouse |
| Alessandra Bulbarelli, Elena Lonati, Emanuela Cazzaniga, Maria Gregori, Massimo Masserin. Pin1 affects Tau phosphorylation in response to Abeta oligomers. Molecular and cellular neurosciences. vol 42. issue 1. 2009-10-20. PMID:19520166. |
we show that in hippocampal cultured neurons, dephosphorylation of peptidyl-prolyl cis-trans isomerase pin1 on ser16 is occurring during the early stages of exposure to abeta (1-42) oligomers. |
2009-10-20 |
2023-08-12 |
Not clear |
| M Moretto Zita, Ivan Marchionni, Elisa Bottos, Massimo Righi, Giannino Del Sal, Enrico Cherubini, Paola Zacch. Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. The EMBO journal. vol 26. issue 7. 2007-05-14. PMID:17347650. |
consistently, a downregulation of glyr clusters was detected in hippocampal neurons derived from pin1 knockout mice, which was paralleled by a reduction in the amplitude of glycine-evoked currents. |
2007-05-14 |
2023-08-12 |
mouse |
| D Allan Butterfield, Hafiz Mohmmad Abdul, Wycliffe Opii, Shelley F Newman, Gururaj Joshi, Mubeen Ahmad Ansari, Rukhsana Sultan. Pin1 in Alzheimer's disease. Journal of neurochemistry. vol 98. issue 6. 2006-11-07. PMID:16945100. |
furthermore, pin1 was found to be oxidatively modified and to have reduced activity in the hippocampus in mild cognitive impairment (mci) and ad. |
2006-11-07 |
2023-08-12 |
Not clear |
| Rukhsana Sultana, Debra Boyd-Kimball, H Fai Poon, Jain Cai, William M Pierce, Jon B Klein, William R Markesbery, Xiao Zhen Zhou, Kun Ping Lu, D Allan Butterfiel. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiology of aging. vol 27. issue 7. 2006-07-27. PMID:15950321. |
the in vivo oxidative modification of pin1 as found by proteomics in ad hippocampus in the present study suggests that oxidative modification may be related to the known loss of pin1 isomerase activity that could be crucial in ad neurofibrillary pathology. |
2006-07-27 |
2023-08-12 |
Not clear |
| Rukhsana Sultana, Debra Boyd-Kimball, H Fai Poon, Jain Cai, William M Pierce, Jon B Klein, William R Markesbery, Xiao Zhen Zhou, Kun Ping Lu, D Allan Butterfiel. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiology of aging. vol 27. issue 7. 2006-07-27. PMID:15950321. |
oxidative modification and down-regulation of pin1 in alzheimer's disease hippocampus: a redox proteomics analysis. |
2006-07-27 |
2023-08-12 |
Not clear |
| Rukhsana Sultana, Debra Boyd-Kimball, H Fai Poon, Jain Cai, William M Pierce, Jon B Klein, William R Markesbery, Xiao Zhen Zhou, Kun Ping Lu, D Allan Butterfiel. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiology of aging. vol 27. issue 7. 2006-07-27. PMID:15950321. |
here, we report that the protein, pin1, is significantly down-regulated and oxidized in ad hippocampus. |
2006-07-27 |
2023-08-12 |
Not clear |
| D Allan Butterfield, H Fai Poon, Daret St Clair, Jeffery N Keller, William M Pierce, Jon B Klein, William R Markesber. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiology of disease. vol 22. issue 2. 2006-07-25. PMID:16466929. |
by using redox proteomics, we determined the oxidatively modified proteins in mci hippocampus to be alpha-enolase (eno1), glutamine synthetase (glul), pyruvate kinase m2 (pkm2) and peptidyl-prolyl cis/trans isomerase 1 (pin1). |
2006-07-25 |
2023-08-12 |
human |
| Max Holzer, Ulrich Gärtner, Andrea Stöbe, Wolfgang Härtig, Hildegard Gruschka, Martina K Brückner, Thomas Arend. Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410395. |
in the present study, we analysed the potential involvement of pin1 in selective vulnerability of hippocampal neurons to neurofibrillary degeneration in alzheimer's disease. |
2002-12-23 |
2023-08-12 |
Not clear |
| Max Holzer, Ulrich Gärtner, Andrea Stöbe, Wolfgang Härtig, Hildegard Gruschka, Martina K Brückner, Thomas Arend. Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus. Acta neuropathologica. vol 104. issue 5. 2002-12-23. PMID:12410395. |
inverse association of pin1 and tau accumulation in alzheimer's disease hippocampus. |
2002-12-23 |
2023-08-12 |
Not clear |