| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
in cardiomyocytes, nicotine significantly increased nadph oxidase 4 (nox4), which coincided with increased reactive oxygen species (ros) and increased cardiomyocyte apoptosis which were dependent on phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
moreover, inhibition of erk1/2 activity by u0126 significantly blocked nicotine induced phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
here, we present a novel finding that nicotine exposure significantly increased phlpp1 protein expression in the adolescent rodent heart. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
mechanistically, nicotine activated extracellular signal-regulated protein kinases (erk1/2) and subsequent eukaryotic translation initiation factor 4e-binding protein 1 (4e-bp1) to increase phlpp1 protein expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
increased phlpp1 expression through erk-4e-bp1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
inhibition of protein synthesis with cycloheximide (chx) and 4egi-1 abolished nicotine induced phlpp1 protein expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
nicotine significantly increased phlpp1 protein expression without altering phlpp2 in cardiomyocytes. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
overall, this study reveals a novel mechanism by which nicotine regulates phlpp1 expression through erk-4e-bp1 signaling axis to drive cardiomyocyte injury. |
2024-06-08 |
2024-06-11 |
Not clear |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
phlpp1 expression was both necessary and sufficient for nicotine induced mitochondrial dysfunction. |
2024-06-08 |
2024-06-11 |
Not clear |