| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shivani Mansingh, Geraldine Maier, Julien Delezie, Pål O Westermark, Danilo Ritz, Wandrille Duchemin, Gesa Santos, Bettina Karrer-Cardel, Stefan A Steurer, Urs Albrecht, Christoph Handschi. More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα. The Journal of physiology. 2024-06-08. PMID:38850551. |
we investigated the outcome of perturbations of the primary and secondary feedback loops of the molecular clock in skeletal muscle by specific gene ablation of period circadian regulator 2 (per2) and rar-related orphan receptor alpha (rorα), respectively. |
2024-06-08 |
2024-06-11 |
Not clear |
| Amira Moustaf. Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats. Frontiers in veterinary science. vol 8. 2021-05-04. PMID:33937367. |
the results demonstrated (1) significant decreases in the circulating levels of interleukin 1β, interleukin 6 and tumor necrosis factor alpha (tnf-α) and significant increases in the levels of interleukin 10, interleukin 12, c-reactive protein (crp) and corticosterone in both ll and dd groups; (2) upregulation in mrna expression of core clock genes cry1, cry2, per1, per2, and per3 in the spleen of the dd group and downregulation in cry1 and cry2 genes in the ll group; (3) elevation of total antioxidant capacity (tac), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), nitric oxide (no) and the lipid peroxidation marker malondialdehyde (mda) in the spleen, lymph node and bone marrow of both the ll and dd groups and decreases in the levels of the same markers in the thymus of the ll group; (4) decreased numbers of cd4 |
2021-05-04 |
2023-08-13 |
rat |
| Carolina López-Cano, Liliana Gutiérrez-Carrasquilla, Ferran Barbé, Enric Sánchez, Marta Hernández, Raquel Martí, Vicky Ceperuelo-Mallafre, Mireia Dalmases, Sonia Fernández-Veledo, Joan Vendrell, Cristina Hernández, Rafael Simó, Albert Lecub. Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes? Journal of clinical medicine. vol 9. issue 8. 2020-09-28. PMID:32823749. |
we examined whether the expression of hypoxia-inducible factor-1α (hif-1α) and hif-2α relates to changes in the expression of clock genes (period homolog proteins (per)1, per2, per3, retinoid-related orphan receptor alpha (rora), aryl hydrocarbon receptor nuclear translocator-like protein 1 (arntl), circadian locomotor output cycles kaput (clock), and cryptochrome proteins (cry) 1 and cry2) in patients with type 2 diabetes. |
2020-09-28 |
2023-08-13 |
human |
| Atish Mukherji, Ahmad Kobiita, Pierre Chambo. Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 48. 2016-04-04. PMID:26627259. |
in turn, peroxisome proliferator-activated receptor alpha (pparα) activation by free fatty acid (ffa), and camp response element-binding protein (creb) activation by glucagon, lead to further metabolic alterations during the circadian active phase, as well as to aberrant activation of expression of the pcc components nuclear receptor subfamily 1, group d, member 1 (nr1d1/reverbα), period (per1 and per2). |
2016-04-04 |
2023-08-13 |
mouse |
| Elaine Vieira, Elena g Ruano, Ana Lucia C Figueroa, Gloria Aranda, Dulce Momblan, Francesc Carmona, Ramon Gomis, Josep Vidal, Felicia A Hanz. Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome. PloS one. vol 9. issue 11. 2016-02-04. PMID:25365257. |
obese subjects with ms exhibited positive correlation in the per2 gene with ldl cholesterol, whereas rev-erb alpha was correlated with waist circumference. |
2016-02-04 |
2023-08-13 |
human |
| Iveta Herichová, Dorota Šoltésová, Kristína Szántóová, Boris Mravec, Denisa Neupauerová, Anna Veselá, Michal Zema. Effect of angiotensin II on rhythmic per2 expression in the suprachiasmatic nucleus and heart and daily rhythm of activity in Wistar rats. Regulatory peptides. vol 186. 2014-05-27. PMID:23850797. |
28days of angii treatment caused significant phase advance and a decrease in nighttime expression of per2 and influenced expression of clock controlled genes rev-erb alpha and dbp in the heart compared to the control. |
2014-05-27 |
2023-08-12 |
rat |
| Nils H Thoennissen, Gabriela B Thoennissen, Sam Abbassi, Shayan Nabavi-Nouis, Tim Sauer, Ngan B Doan, Sigal Gery, Carsten Müller-Tidow, Jonathan W Said, H Phillip Koeffle. Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma. Leukemia & lymphoma. vol 53. issue 8. 2012-12-10. PMID:22260161. |
we show that transcription factor ccaat/enhancer-binding protein alpha (c/ebpalpha)-regulated per2 activation is a potential tumor suppressor pathway in diffuse large b-cell lymphoma (dlbcl), one of the commonest types of mature b-cell lymphoma. |
2012-12-10 |
2023-08-12 |
human |
| Nils H Thoennissen, Gabriela B Thoennissen, Sam Abbassi, Shayan Nabavi-Nouis, Tim Sauer, Ngan B Doan, Sigal Gery, Carsten Müller-Tidow, Jonathan W Said, H Phillip Koeffle. Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma. Leukemia & lymphoma. vol 53. issue 8. 2012-12-10. PMID:22260161. |
transcription factor ccaat/enhancer-binding protein alpha and critical circadian clock downstream target gene per2 are highly deregulated in diffuse large b-cell lymphoma. |
2012-12-10 |
2023-08-12 |
human |
| Jie Huang, Chao Lu, Sifen Chen, Luchun Hua, Ruizhe Qia. Postnatal ontogenesis of clock genes in mouse suprachiasmatic nucleus and heart. Lipids in health and disease. vol 9. 2010-11-24. PMID:20202222. |
the daily expression of four clock genes mrna (bmal1, per2, cry1 and rev-erb alpha) in mouse scn and heart was measured at p1, p3 and p5 by real-time pcr. |
2010-11-24 |
2023-08-12 |
mouse |
| Gianluca Tosini, Manami Kasamatsu, Katsuhiko Sakamot. Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration. Brain research. vol 1159. 2007-10-12. PMID:17560558. |
in ll, the transcripts for per1, per2, clock and rev-erb alpha showed significant temporal variations. |
2007-10-12 |
2023-08-12 |
rat |
| Barbara A Murphy, Mandi M Vick, Dawn R Sessions, R Frank Cook, Barry P Fitzgeral. Acute systemic inflammation transiently synchronizes clock gene expression in equine peripheral blood. Brain, behavior, and immunity. vol 21. issue 4. 2007-07-17. PMID:17174528. |
we report that in vivo administration of lipopolysaccharide (lps) results in significant upregulation of the core clock genes per2 and bmal1 in equine blood, in association with an acute rise in tumor necrosis factor (tnf) alpha and core body temperature compared to vehicle-treated control animals. |
2007-07-17 |
2023-08-12 |
Not clear |