| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ching-Wen Tsai, Tzung-Yu Chen, Jyh-Horng Wang, Tai-Horng Youn. Effect of Chitosan on Synovial Membrane Derived Cells and Anterior Cruciate Ligament Fibroblasts. Tissue engineering. Part A. 2024-05-02. PMID:38695112. |
we found that chitosan treatment effectively reduced aging-associated β-galactosidase (sa-β-gal)-positive cells, downregulated the expression of senescence-related proteins prb and p53, and enhanced the 5-bromo-2'-deoxyuridine (brdu) incorporation ability of scs and acls. |
2024-05-02 |
2024-05-04 |
human |
| Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Che. Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury. Molecular neurobiology. 2024-01-29. PMID:38285287. |
our mechanism research indicated that dpsc-exos could deliver mir-122-5p from dpscs into scs and suppressed the rapamycin (rapa)-induced autophagy in scs by inhibiting p53 expression. |
2024-01-29 |
2024-01-31 |
rat |
| Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Che. Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury. Molecular neurobiology. 2024-01-29. PMID:38285287. |
rescue experiments showed that both the use of gw4869 and overexpression of exogenous p53 in scs could reverse the inhibitory effect of dpscs on the autophagy in scs from co-culture system. |
2024-01-29 |
2024-01-31 |
rat |
| Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Che. Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury. Molecular neurobiology. 2024-01-29. PMID:38285287. |
our results showed that the scs of sni rats exhibited the obvious autophagic characteristics, and the increase of p53 expression was an internal factor of autophagy. |
2024-01-29 |
2024-01-31 |
rat |
| Sònia Gatius, Mariona Jove, Cristina Megino-Luque, Manel Albertí-Valls, Andree Yeramian, Nuria Bonifaci, Miquel Piñol, Maria Santacana, Irene Pradas, David Llobet-Navas, Reinald Pamplona, Xavier Matías-Guiu, Núria Eritj. Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer. Cancers. vol 14. issue 12. 2022-06-24. PMID:35740505. |
altogether, these results suggest that adi1 could be a potential therapeutic target in poor-prognosis scs and other ecs with abnormal p53 expression. |
2022-06-24 |
2023-08-14 |
Not clear |
| Alexandra Charruyer, Tracy Weisenberger, Hang Li, Ayman Khalifa, Andrew W Schroeder, Annika Belzer, Ruby Ghadiall. Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. Aging cell. vol 20. issue 2. 2021-09-06. PMID:33524216. |
fewer aged than adult aldh+cd44+ keratinocyte scs exhibited p53 expression and activity and nutlin-3 (a p53 activator) returned p53 activity as well as asymmetric sc self-renewal divisions to adult levels. |
2021-09-06 |
2023-08-13 |
human |
| Michaela Ihle, Stephanie Biber, Insa S Schroeder, Christine Blattner, Miriam Deniz, Giovanna Damia, Vanesa Gottifredi, Lisa Wiesmülle. Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices. Nucleic acids research. vol 49. issue 13. 2021-08-09. PMID:34165573. |
by exploring protein interactions and newly synthesized dna, we show that scs promote complex formation of p53 and polι at replication sites. |
2021-08-09 |
2023-08-13 |
human |
| Gabriela Koifman, Ronit Aloni-Grinstein, Varda Rotte. p53 balances between tissue hierarchy and anarchy. Journal of molecular cell biology. vol 11. issue 7. 2020-07-14. PMID:30925590. |
moreover, p53 serves as a barrier for dedifferentiation and reprogramming by constraining the cells to a somatic state and preventing their conversion to scs. |
2020-07-14 |
2023-08-13 |
Not clear |
| Xianmin Wu, Xiaofei Li, Yongdong Song, He Li, Xiaohui Bai, Wenwen Liu, Yuechen Han, Lei Xu, Jianfeng Li, Daogong Zhang, Haibo Wang, Zhaomin Fa. Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin - Induced apoptosis. Neuropharmacology. vol 116. 2018-05-09. PMID:28062185. |
all data suggested that allicin could prevent hearing loss induced by cisplatin effectively, of which allicin protected sgns from apoptosis via mitochondrial pathway while protected ohcs and supporting cells (scs) from apoptosis through p53 pathway. |
2018-05-09 |
2023-08-13 |
mouse |
| Alina Molchadsky, Varda Rotte. p53 and its mutants on the slippery road from stemness to carcinogenesis. Carcinogenesis. vol 38. issue 4. 2017-04-25. PMID:28334334. |
multiple experimental evidence suggest that p53, the central tumor suppressor gene, plays a critical regulatory role in determination of scs destiny, thereby eliminating damaged scs from the general sc population. |
2017-04-25 |
2023-08-13 |
Not clear |
| Alina Molchadsky, Varda Rotte. p53 and its mutants on the slippery road from stemness to carcinogenesis. Carcinogenesis. vol 38. issue 4. 2017-04-25. PMID:28334334. |
in this review, we elaborate on the role of wild type and mutant p53 proteins in the various scs types that appear under homeostatic conditions as well as in cancer. |
2017-04-25 |
2023-08-13 |
Not clear |
| S Fouchécourt, G Livera, S Messiaen, B Fumel, A-S Parent, J-C Marine, P Monge. Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility. Cell death and differentiation. vol 23. issue 3. 2016-11-01. PMID:26470726. |
we specifically tested this possibility by ablating mdm2, an e3 ligase that regulates p53 protein stability and transactivation function, specifically in sertoli cells (scs) using the amh-cre line and created the new sc-mdm2(-/-) line. |
2016-11-01 |
2023-08-13 |
mouse |
| S Fouchécourt, G Livera, S Messiaen, B Fumel, A-S Parent, J-C Marine, P Monge. Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility. Cell death and differentiation. vol 23. issue 3. 2016-11-01. PMID:26470726. |
these data not only highlight the importance of keeping p53 in check for proper testicular development and male fertility but also certify the critical role of scs in the maintenance of meiotic repression. |
2016-11-01 |
2023-08-13 |
mouse |
| S Fouchécourt, G Livera, S Messiaen, B Fumel, A-S Parent, J-C Marine, P Monge. Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility. Cell death and differentiation. vol 23. issue 3. 2016-11-01. PMID:26470726. |
inactivation of mdm2 in scs triggered p53 activation and apoptosis as early as 15.5 days post conception with significant increase in apoptotic scs. |
2016-11-01 |
2023-08-13 |
mouse |
| Zhang Jiao Jiao, Wang Yi, Yang Wei Rong, Jeong Dong Kee, Wang Xian Zhon. MicroRNA-1285 Regulates 17β-Estradiol-Inhibited Immature Boar Sertoli Cell Proliferation via Adenosine Monophosphate-Activated Protein Kinase Activation. Endocrinology. vol 156. issue 11. 2016-04-12. PMID:26287402. |
a double-stranded synthetic mir-1285 mimic promoted sc viability, increased levels of atp, and phosphorylated mammalian target of rapamycin (mtor) and skp2 mrna and protein, whereas p53 and p27 expression decreased, and 17β-estradiol-mediated effects on scs were significantly attenuated. |
2016-04-12 |
2023-08-13 |
Not clear |
| Monika Petersson, Karen Reuter, Heike Brylka, Andreas Kraus, Peter Schettina, Catherin Nieman. Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours. Nature communications. vol 6. 2016-03-29. PMID:25608467. |
mechanistically, we demonstrate that mutant lef1 abolishes p53 activity in scs. |
2016-03-29 |
2023-08-13 |
human |
| Daniela Tosoni, Silvia Zecchini, Marco Coazzoli, Ivan Colaluca, Giovanni Mazzarol, Alicia Rubio, Michele Caccia, Emanuele Villa, Olav Zilian, Pier Paolo Di Fiore, Salvatore Pec. The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells. The Journal of cell biology. vol 211. issue 4. 2016-03-09. PMID:26598619. |
here, by exploiting an ex vivo system, we show that at mitosis of purified mammary stem cells (scs), numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the sc identity, where it sustains high p53 activity. |
2016-03-09 |
2023-08-13 |
mouse |
| Maarja Laos, Tommi Anttonen, Anna Kirjavainen, Taija af Hällström, Marikki Laiho, Ulla Pirvol. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging. vol 6. issue 6. 2015-02-23. PMID:25063730. |
phosphorylated form of histone h2ax (γh2ax) and p53 binding protein 1 (53bp1) were induced in a foci-like pattern in scs of both ages as an indication of dna double-strand break formation and activated dna damage response. |
2015-02-23 |
2023-08-13 |
mouse |
| T R Dias, L Rato, A D Martins, V L Simões, T T Jesus, M G Alves, P F Oliveir. Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat sertoli cells. ISRN urology. vol 2013. 2013-11-14. PMID:24228182. |
scs cultured in insulin deprivation demonstrated a significant decrease on mrna levels of p53, bax, caspase-9, and caspase-3 followed by a significant increase of bax and decrease of caspase-9 protein levels relatively to the control. |
2013-11-14 |
2023-08-12 |
rat |
| Panagiota A Sotiropoulou, Andrea E Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers, Cedric Blanpai. BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes & development. vol 27. issue 1. 2013-02-26. PMID:23271346. |
concomitant deletion of p53 and brca1 rescues the defect of hf morphogenesis and loss of hf scs. |
2013-02-26 |
2023-08-12 |
mouse |