| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kim Kobar, Lissandra Tuzi, Jennifer A Fiene, Erin Burnley, Kristianne J C Galpin, Craig Midgen, Brianne Laverty, Vallijah Subasri, Timmy T Wen, Martin Hirst, Michelle Moksa, Annaick Carles, Qi Cao, Adam Shlien, David Malkin, Sergey V Prykhozhij, Jason N Berma. tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes. Biochimica et biophysica acta. Molecular basis of disease. vol 1871. issue 3. 2024-12-07. PMID:39643218. |
we characterized the first lfs zebrafish hotspot mutants, tp53 r217h and r242h (human r248h and r273h), and found these mutants exhibit partial-to-no activation of p53 target genes, have defective cell-cycle checkpoints, and display partial-to-full resistance to apoptosis, although the r217h mutation has hypomorphic characteristics. |
2024-12-07 |
2024-12-10 |
human |
| Yuanyuan Jia, Xinyue Zhang, Yiqing Cai, Hanghui Yu, Guohua Cao, Enyong Dai, Rui Kang, Daolin Tang, Nanjun Hu, Leng Ha. OSGIN1 promotes ferroptosis resistance by directly enhancing GCLM activity. Biochemical and biophysical research communications. vol 740. 2024-11-21. PMID:39571229. |
oxidative stress induced growth inhibitor 1 (osgin1) is a tumor protein p53 (tp53)-target gene involved in the oxidative stress response and promotes apoptosis. |
2024-11-21 |
2024-11-24 |
human |
| Yangtao Jin, Ping Zhou, Sisi Huang, Congcong Shao, Dongyan Huang, Xin Su, Rongfu Yang, Juan Jiang, Jianhui W. Cucurbitacin B Inhibits the Proliferation of WPMY-1 Cells and HPRF Cells via the p53/MDM2 Axis. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273281. |
our results mirrored the regulation of tumor protein p53 (tp53), mouse double minute-2 (mdm2), cyclin d1 (ccnd1), and thrombospondin 1 (thbs1) in cu b-induced prostate cell apoptosis. |
2024-09-14 |
2024-09-16 |
mouse |
| Andreas Gollner, Dorothea Rudolph, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, Guido Boehmelt, Darryl B McConnell, Norbert Kraut, Patrizia Sin. Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules. Molecular cancer therapeutics. 2024-09-11. PMID:39259562. |
brigimadlin treatment restored p53 activity and led to apoptosis induction in preclinical models of tp53 wild-type, mdm2-amplified cancer. |
2024-09-11 |
2024-09-13 |
mouse |
| Haohao Wang, Qingjie Chen, Qinghua Liu, Changjiang Lu. Master regulator: p53's pivotal role in steering NK-cell tumor patrol. Frontiers in immunology. vol 15. 2024-08-26. PMID:39185404. |
the p53 protein, encoded by tp53, is a tumor suppressor that plays a critical role in regulating apoptosis, cell cycle regulation, and angiogenesis in tumor cells via controlling various downstream signals. |
2024-08-26 |
2024-08-28 |
Not clear |
| Hsuan-Yu Huang, Chia-Hung Chen, Fang-Ju Cheng, Bo-Wei Wang, Chih-Yen Tu, Yun-Ju Chen, Yu-Hao He, Chun-Hsu Yao, Wei-Chien Huan. Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer. Journal of hazardous materials. vol 477. 2024-07-24. PMID:39047551. |
tumor protein p53 (tp53)-activated long intergenic non-coding rna-p21 (lincrna-p21) undertakes a pivotal role in regulating cell apoptosis and chemosensitivity. |
2024-07-24 |
2024-07-28 |
Not clear |
| Liu-Yan Chen, Chuan-Mei Wu, Pan Liang, Jin-Feng Wei, Ting-Ting Lan, Min Guo, Yong-Hua Li, Mei R. [Anti-inflammatory effect and its mechanism of Saracae Cortex based on zebrafish model and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 11. 2024-07-23. PMID:39041167. |
protein-protein interaction(ppi) analysis showed that saracae cortex mainly acted on signal transducer and activator of transcription 3(stat3), vascular endothelial growth factor a( vegfa), epidermal growth factor( egf), tumor necrosis factor( tnf),tumor protein p53(tp53), matrix metalloprotein 9(mmp9), c-fos proto-oncogene protein(fos), estrogen receptor 1(esr1), cx-c motif chemokine ligand 8(cxcl8), cluster of differentiation 8(cd8), and other targets. |
2024-07-23 |
2024-07-25 |
zebrafish |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). |
2024-07-19 |
2024-07-21 |
mouse |
| Jillian A Bristol, Scott E Nelson, Makoto Ohashi, Alejandro Casco, Mitchell Hayes, Erik A Ranheim, Abigail S Pawelski, Deo R Singh, Daniel J Hodson, Eric C Johannsen, Shannon C Kenne. Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice. PLoS pathogens. vol 20. issue 4. 2024-04-15. PMID:38620028. |
suppression of myc-induced apoptosis, often through mutation of the tp53 (p53) gene or inhibition of pro-apoptotic bcl2l11 (bim) gene expression, is required for development of myc-driven bls. |
2024-04-15 |
2024-04-18 |
mouse |
| Yujing Xu, Jinrong Yang, Xiaoyu Han, Chunchun Gan, Xiaopeng We. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. vol 103. issue 15. 2024-04-12. PMID:38608062. |
tumor protein p53 (tp53), akt serine/threonine kinase 1 (akt1), estrogen receptor 1 (esr1), erb-b2 receptor tyrosine kinase 2 (erbb2), epidermal growth factor receptor (egfr), jun proto-oncogene (jun), and heat shock protein 90 alpha family class a member 1 (hsp90aa1) selected as the most important genes were used for verification by molecular docking and molecular dynamics simulation. |
2024-04-12 |
2024-04-15 |
Not clear |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Elizabeth O Ferreira, Alexandra M Schefter, Abby Brustad, Molly E Klein, Mahmoud A Khalifa, Boris Winterhoff, Andrew C Nelso. Implementation of endometrial cancer molecular subtyping into a hybrid community-academic practice. American journal of clinical pathology. 2024-03-02. PMID:38430556. |
we sought to confirm utility of our institution's modified proactive molecular risk classifier for endometrial cancer protocol in our daily practice, which includes mismatch repair (mmr), p53, and l1 cell adhesion molecule (l1cam) immunohistochemistry with in-house next-generation sequencing for pole, tp53, and ctnnb1. |
2024-03-02 |
2024-03-05 |
Not clear |
| Wei-Xi Shen, Guang-Hua Li, Yu-Jia Li, Peng-Fei Zhang, Jia-Xing Yu, Di Shang, Qiu-Shi Wan. Prognostic Significance of Tumor Mutation Burden among Patients with Non-small Cell Lung Cancer Who Received Platinum-based Adjuvant Chemotherapy: An Exploratory Study. Journal of cancer prevention. vol 28. issue 4. 2024-01-11. PMID:38205359. |
ngs analysis exhibited that the most common mutated somatic genes among the 78 patients were tumor suppressor protein p53 (tp53), epidermal growth factor receptor, low-density lipoprotein receptor related protein 1b, dna methyltransferase 3 alpha and fat atypical cadherin 3, and their prevalence was 56.4%, 48.7%, 37.2%, 30.7%, and 25.6%, respectively. |
2024-01-11 |
2024-01-13 |
Not clear |
| Xiao-Qin Zhong, Da-Feng Hu, Yu Wang, Zhen-Qiu Ning, Min-Zhen Den. [Mechanism of Zhongfeng Xingnao Decoction in improving microcirculatory disorders in cerebral hemorrhage based on network pharmacology and molecular docking techniques]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114219. |
molecular docking results revealed that the common components β-sitosterol of rhei radix et rhizoma, notoginseng radix et rhizoma, and ginseng radix et rhizoma rubra showed good docking with proto-oncogene tyrosine-protein kinase(src), signal transducer and activator of transcription 3(stat3), phosphoinositide-3-kinase catalytic alpha polypeptide gene(pik3ca), recombinant protein tyrosine phosphatase non receptor type 11(ptpn11), akt1, epidermal growth factor receptor(egfr), calcium adhesion-associated protein beta 1(ctnnb1), vascular endothelial growth factor a(vegfa), and tumor protein p53(tp53). |
2023-12-19 |
2023-12-23 |
mouse |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G Park, Joshua LaBae. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. NPJ breast cancer. vol 9. issue 1. 2023-09-29. PMID:37773066. |
to test whether neomorphic functions of specific tp53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed mcf10a-derived cell lines expressing the ten most common missense mutant p53 proteins and observed a wide spectrum of phenotypic changes in cell survival, resistance to apoptosis and anoikis, cell migration, invasion and 3d mammosphere architecture. |
2023-09-29 |
2023-10-07 |
Not clear |
| Karley Whelan, Mairead Dillon, Kyle C Strickland, Bhavana Pothuri, Victoria Bae-Jump, Lindsay E Borden, Premal H Thaker, Paulina Haight, Rebecca C Arend, Emily Ko, Amanda L Jackson, Bradley R Corr, Martins Ayoola-Adeola, Jason D Wright, Sarah Podwika, Carson Smitherman, Samantha Thomas, Michelle Lightfoot, Meredith Newton, Christina Washington, Mary Mullen, Casey Cosgrove, Alfonsus Adrian Hadikusumo Harsono, Kristina Powell, Thomas J Herzog, Ritu Salani, Angeles Alvarez Secor. TP53 mutation and abnormal p53 expression in endometrial cancer: Associations with race and outcomes. Gynecologic oncology. vol 178. 2023-09-25. PMID:37748270. |
this multi-center cohort study assessed associations between race, tp53 mutations, p53 expression, and histology to investigate racial survival disparities in endometrial cancer (ec). |
2023-09-25 |
2023-10-07 |
Not clear |
| Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Gautam Borthakur, Musa Yilmaz, Ghayas C Issa, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D DiNard. A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis. Blood cancer journal. vol 13. issue 1. 2023-06-29. PMID:37386016. |
in tp53 wild-type acute myeloid leukemia (aml), inhibition of mdm2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. |
2023-06-29 |
2023-08-14 |
Not clear |
| Nana Matsumoto, Padmini Manrai, Douglas Rottmann, Xinyu Wu, Hisham Assem, Pei Hui, Natalia Buz. Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2023-02-02. PMID:36730675. |
our results further support that p53 ihc can serve as an accurate predictor of tp53 alterations in ecs to aid the molecular-based tumor classification and the distinction between tumor histotypes, both of which play an important role in the assessment of clinical prognosis and therapeutic decision making. |
2023-02-02 |
2023-08-14 |
Not clear |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
the mutations in the tp53 gene are the most frequent (50-60% of human cancer) genetic alterations in cancer cells, indicating the critical role of wild-type p53 in the regulation of cell proliferation and apoptosis upon oncogenic stress. |
2023-01-26 |
2023-08-14 |
human |