| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liu-Yan Chen, Chuan-Mei Wu, Pan Liang, Jin-Feng Wei, Ting-Ting Lan, Min Guo, Yong-Hua Li, Mei R. [Anti-inflammatory effect and its mechanism of Saracae Cortex based on zebrafish model and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 11. 2024-07-23. PMID:39041167. |
protein-protein interaction(ppi) analysis showed that saracae cortex mainly acted on signal transducer and activator of transcription 3(stat3), vascular endothelial growth factor a( vegfa), epidermal growth factor( egf), tumor necrosis factor( tnf),tumor protein p53(tp53), matrix metalloprotein 9(mmp9), c-fos proto-oncogene protein(fos), estrogen receptor 1(esr1), cx-c motif chemokine ligand 8(cxcl8), cluster of differentiation 8(cd8), and other targets. |
2024-07-23 |
2024-07-25 |
zebrafish |
| Xiu-Li Zhang, Jia-Peng Li, Mei-Zhu Wu, Jin-Kong Wu, Shu-Yu He, Yao Lu, Qi-Hang Ding, Ying Wen, Lin-Zi Long, Chang-Geng Fu, Ali Farman, A-Ling Shen, Jun Pen. Quercetin protects against hypertensive renal injury by attenuating apoptosis: an integrated approach using network pharmacology and RNA-Seq. Journal of cardiovascular pharmacology. 2024-07-19. PMID:39027976. |
network pharmacology analysis identified multiple potential candidate targets (including tp53, bcl-2 and bax) and enriched signaling pathways (including apoptosis and p53 signaling pathway). |
2024-07-19 |
2024-07-21 |
mouse |
| Jillian A Bristol, Scott E Nelson, Makoto Ohashi, Alejandro Casco, Mitchell Hayes, Erik A Ranheim, Abigail S Pawelski, Deo R Singh, Daniel J Hodson, Eric C Johannsen, Shannon C Kenne. Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice. PLoS pathogens. vol 20. issue 4. 2024-04-15. PMID:38620028. |
suppression of myc-induced apoptosis, often through mutation of the tp53 (p53) gene or inhibition of pro-apoptotic bcl2l11 (bim) gene expression, is required for development of myc-driven bls. |
2024-04-15 |
2024-04-18 |
mouse |
| Yujing Xu, Jinrong Yang, Xiaoyu Han, Chunchun Gan, Xiaopeng We. Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study. Medicine. vol 103. issue 15. 2024-04-12. PMID:38608062. |
tumor protein p53 (tp53), akt serine/threonine kinase 1 (akt1), estrogen receptor 1 (esr1), erb-b2 receptor tyrosine kinase 2 (erbb2), epidermal growth factor receptor (egfr), jun proto-oncogene (jun), and heat shock protein 90 alpha family class a member 1 (hsp90aa1) selected as the most important genes were used for verification by molecular docking and molecular dynamics simulation. |
2024-04-12 |
2024-04-15 |
Not clear |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Elizabeth O Ferreira, Alexandra M Schefter, Abby Brustad, Molly E Klein, Mahmoud A Khalifa, Boris Winterhoff, Andrew C Nelso. Implementation of endometrial cancer molecular subtyping into a hybrid community-academic practice. American journal of clinical pathology. 2024-03-02. PMID:38430556. |
we sought to confirm utility of our institution's modified proactive molecular risk classifier for endometrial cancer protocol in our daily practice, which includes mismatch repair (mmr), p53, and l1 cell adhesion molecule (l1cam) immunohistochemistry with in-house next-generation sequencing for pole, tp53, and ctnnb1. |
2024-03-02 |
2024-03-05 |
Not clear |
| Wei-Xi Shen, Guang-Hua Li, Yu-Jia Li, Peng-Fei Zhang, Jia-Xing Yu, Di Shang, Qiu-Shi Wan. Prognostic Significance of Tumor Mutation Burden among Patients with Non-small Cell Lung Cancer Who Received Platinum-based Adjuvant Chemotherapy: An Exploratory Study. Journal of cancer prevention. vol 28. issue 4. 2024-01-11. PMID:38205359. |
ngs analysis exhibited that the most common mutated somatic genes among the 78 patients were tumor suppressor protein p53 (tp53), epidermal growth factor receptor, low-density lipoprotein receptor related protein 1b, dna methyltransferase 3 alpha and fat atypical cadherin 3, and their prevalence was 56.4%, 48.7%, 37.2%, 30.7%, and 25.6%, respectively. |
2024-01-11 |
2024-01-13 |
Not clear |
| Xiao-Qin Zhong, Da-Feng Hu, Yu Wang, Zhen-Qiu Ning, Min-Zhen Den. [Mechanism of Zhongfeng Xingnao Decoction in improving microcirculatory disorders in cerebral hemorrhage based on network pharmacology and molecular docking techniques]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114219. |
molecular docking results revealed that the common components β-sitosterol of rhei radix et rhizoma, notoginseng radix et rhizoma, and ginseng radix et rhizoma rubra showed good docking with proto-oncogene tyrosine-protein kinase(src), signal transducer and activator of transcription 3(stat3), phosphoinositide-3-kinase catalytic alpha polypeptide gene(pik3ca), recombinant protein tyrosine phosphatase non receptor type 11(ptpn11), akt1, epidermal growth factor receptor(egfr), calcium adhesion-associated protein beta 1(ctnnb1), vascular endothelial growth factor a(vegfa), and tumor protein p53(tp53). |
2023-12-19 |
2023-12-23 |
mouse |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G Park, Joshua LaBae. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. NPJ breast cancer. vol 9. issue 1. 2023-09-29. PMID:37773066. |
to test whether neomorphic functions of specific tp53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed mcf10a-derived cell lines expressing the ten most common missense mutant p53 proteins and observed a wide spectrum of phenotypic changes in cell survival, resistance to apoptosis and anoikis, cell migration, invasion and 3d mammosphere architecture. |
2023-09-29 |
2023-10-07 |
Not clear |
| Karley Whelan, Mairead Dillon, Kyle C Strickland, Bhavana Pothuri, Victoria Bae-Jump, Lindsay E Borden, Premal H Thaker, Paulina Haight, Rebecca C Arend, Emily Ko, Amanda L Jackson, Bradley R Corr, Martins Ayoola-Adeola, Jason D Wright, Sarah Podwika, Carson Smitherman, Samantha Thomas, Michelle Lightfoot, Meredith Newton, Christina Washington, Mary Mullen, Casey Cosgrove, Alfonsus Adrian Hadikusumo Harsono, Kristina Powell, Thomas J Herzog, Ritu Salani, Angeles Alvarez Secor. TP53 mutation and abnormal p53 expression in endometrial cancer: Associations with race and outcomes. Gynecologic oncology. vol 178. 2023-09-25. PMID:37748270. |
this multi-center cohort study assessed associations between race, tp53 mutations, p53 expression, and histology to investigate racial survival disparities in endometrial cancer (ec). |
2023-09-25 |
2023-10-07 |
Not clear |
| Jayastu Senapati, Muharrem Muftuoglu, Jo Ishizawa, Hussein A Abbas, Sanam Loghavi, Gautam Borthakur, Musa Yilmaz, Ghayas C Issa, Samuel I Dara, Mahesh Basyal, Li Li, Kiran Naqvi, Rasoul Pourebrahim, Elias J Jabbour, Steven M Kornblau, Nicholas J Short, Naveen Pemmaraju, Guillermo Garcia-Manero, Farhad Ravandi, Joseph Khoury, Naval Daver, Hagop M Kantarjian, Michael Andreeff, Courtney D DiNard. A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis. Blood cancer journal. vol 13. issue 1. 2023-06-29. PMID:37386016. |
in tp53 wild-type acute myeloid leukemia (aml), inhibition of mdm2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. |
2023-06-29 |
2023-08-14 |
Not clear |
| Nana Matsumoto, Padmini Manrai, Douglas Rottmann, Xinyu Wu, Hisham Assem, Pei Hui, Natalia Buz. Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2023-02-02. PMID:36730675. |
our results further support that p53 ihc can serve as an accurate predictor of tp53 alterations in ecs to aid the molecular-based tumor classification and the distinction between tumor histotypes, both of which play an important role in the assessment of clinical prognosis and therapeutic decision making. |
2023-02-02 |
2023-08-14 |
Not clear |
| Saksham Garg, Japneet Singh, Smita Rastogi Verm. Targeting Y220C mutated p53 by Foeniculum vulgare-derived phytochemicals as cancer therapeutics. Journal of molecular modeling. vol 29. issue 2. 2023-01-26. PMID:36700982. |
the mutations in the tp53 gene are the most frequent (50-60% of human cancer) genetic alterations in cancer cells, indicating the critical role of wild-type p53 in the regulation of cell proliferation and apoptosis upon oncogenic stress. |
2023-01-26 |
2023-08-14 |
human |
| Bowen Yang, Qiuwen Zhu, Xiaodong Wang, Jingxin Mao, Shuqing Zho. Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis. Medicine. vol 101. issue 49. 2023-01-10. PMID:36626454. |
a total of 24 core target genes were obtained, mainly including tumor protein p53 (tp53), vascular endothelial growth factor a (vegfa), interleukin-6 (il6), tumor necrosis factor (tnf), caspase3 (casp3), matrix metallo protein (mmp9), transcription factor ap-1 (jun), activator of transcription 3 (stat3), mitogen-activated protein kinase 8 (mapk8), and prostaglandin endoperoxidase 2 (ptgs2), respectively. |
2023-01-10 |
2023-08-14 |
Not clear |
| Efstathios T Pavlidis, Konstantinos G Sapalidis, Theodoros E Pavlidi. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 63. issue 3. 2023-01-02. PMID:36588487. |
the genes most frequently altered include kirsten rat sarcoma viral proto-oncogene (kras), tumor protein p53 (tp53), cyclin-dependent kinase inhibitor 2a (cdkn2a), smad family member 4 (smad4), and guanine nucleotide-binding protein, alpha stimulating (gnas). |
2023-01-02 |
2023-08-14 |
rat |
| Xiao-Hui Wu, Jun-Ming Zhu, Bo-Han Lin, Qian-Ren-Shun Qiu, Zhong-Tian Ruan, Yong Wei, Xue-Yi Xue, Qing-Shui Zheng, Shao-Hao Chen, Ning X. Semantic computed tomography features for predicting BRCA1-associated protein 1 and/or tumor protein p53 gene mutation status in clear cell renal cell carcinoma. International journal of radiation oncology, biology, physics. 2022-12-31. PMID:36586494. |
to explore the semantic computed tomography (ct) features associated with brca1-associated protein 1 (bap1) and/or tumor protein p53 (tp53) mutation in clear cell renal cell carcinoma (ccrcc). |
2022-12-31 |
2023-08-14 |
Not clear |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Karie Chen, Xing Qiu, Cara Clementelli, Lauren Herschbein, Zhijun Li, Sebastian Elghaity-Beckley, Joann Arandela, Brianna Kelly, Ronald Hoffman, Jing Liu, Yue Xiong, Jian Jin, Alan H Shi. An MDM2 degrader for treatment of acute leukemias. Leukemia. 2022-10-30. PMID:36309559. |
in wt tp53 leukemia cell lines, ms3227 led to activation of p53 targets p21, puma, and mdm2 and resulted in cell-cycle arrest, apoptosis, and decreased viability. |
2022-10-30 |
2023-08-14 |
Not clear |
| Ying Li, Meng Wu, Lili Zhang, Li Wan, Hexin Li, Lanxin Zhang, Gaoyuan Sun, Wei Huang, Junhua Zhang, Fei Su, Min Tang, Fei Xia. Nonsense-mediated mRNA decay inhibition synergizes with MDM2 inhibition to suppress TP53 wild-type cancer cells in p53 isoform-dependent manner. Cell death discovery. vol 8. issue 1. 2022-09-30. PMID:36180435. |
the combination of these two agents achieved significant synergistic effects on tp53 wild-type cancer cell lines by transactivating p53 target genes, inducing apoptosis, cell-cycle arrest and dna damage repair. |
2022-09-30 |
2023-08-14 |
mouse |