| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Ali Akar, Rahime Özlem Öztopuz, Başak Büyük, Mehmet Akif Ovali, Damla Aykora, Ümit Ali Malço. Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular neurobiology. 2023-03-18. PMID:36933146. |
in this study, we aimed to investigate the potential therapeutic effects of pic on ob injury following sah at molecular mechanism based on sirt1, inflammatory (tnf-α, il1-β, nf-κb, il-6, tlr4), and apoptosis (p53, bax, bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male wistar albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. |
2023-03-18 |
2023-08-14 |
rat |
| Xue Rong, Yuli Wang, Fangxin Ouyang, Weixuan Song, Songhua Li, Feng Li, Shancang Zhao, Dapeng L. Combined effects of zearalenone and deoxynivalenol on oxidative stress, hepatotoxicity, apoptosis, and inflammation in zebrafish embryos. The Science of the total environment. 2022-11-20. PMID:36403834. |
besides, the combined treatment of zea and don triggered hepatotoxicity as shown by the changes of fabp10a, gclc, gsr, nqo1 genes, apoptosis through upregulating apoptosis-related genes (p53, caspase-9, caspase-3) and downregulating bcl-2 gene, as well as inflammation by promoting the expression of il-1β, il-6, tnf-α, tlr4, myd88, nf-κbp65 genes. |
2022-11-20 |
2023-08-14 |
cat |
| Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Krzysztof Marycz, Lynda Bourebaba, Anna Kowalczu. Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis - Possible implication in pharmacotherapy. Mitochondrion. vol 59. 2021-09-13. PMID:34091077. |
the obtained results showed that the bioactive extract of laurus nobilis increased the number of living cells and their proliferation rate, significantly attenuated apoptosis by modulating pro-apoptotic pathways (p21, p53 and bax genes), allowed a relative normalization of caspases-activity, and decreased the expression of inflammatory markers including c-jun, nf-κb and tlr4 transcripts. |
2021-09-13 |
2023-08-13 |
Not clear |
| Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan He. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. Experimental neurology. vol 345. 2021-09-07. PMID:34343528. |
hi insult significantly upregulated the tlr4, increased the p53 level, reduced the slc7a11 and gpx4 levels, and caused mitochondrial damage, thereby inducing neuronal ferroptosis in the hippocampus. |
2021-09-07 |
2023-08-13 |
rat |
| Parmeshwar Bajirao Katare, Hina Lateef Nizami, Bugga Paramesha, Amit K Dinda, Sanjay K Banerje. Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation. Scientific reports. vol 10. issue 1. 2021-03-10. PMID:33159115. |
activation of toll like receptor 4 (tlr4) promotes cardiomyocyte apoptosis through sirt2 dependent p53 deacetylation. |
2021-03-10 |
2023-08-13 |
rat |