| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yating Xu, Di Xia, Kai Huang, Minglu Lian. Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1. Journal of translational medicine. vol 22. issue 1. 2024-01-18. PMID:38238754. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1), the catalytic subunit of collagen prolyl 4-hydroxylase, is a glycolysis-related gene in cancers. |
2024-01-18 |
2024-01-21 |
Not clear |
| Yiting Zhou, Jiajia Tian, Yi Zhu, Yating Zhang, Xudong Zha. Multilevel chitosan-gelatin particles loaded with P4HA1 siRNA suppress glioma development. Drug delivery and translational research. 2023-09-04. PMID:37667088. |
it has been reported that prolyl 4-hydroxylase subunit alpha 1 (p4ha1) promoted tumor growth and metastasis of glioma; thus, targeting p4ha1 may be a promising therapeutic strategy against glioma. |
2023-09-04 |
2023-09-07 |
mouse |
| Guangjin Chen, Qingming Tang, Shaoling Yu, Yufeng Shen, Jiwei Sun, Jinfeng Peng, Ying Yin, Guangxia Feng, Xiaofeng Lu, Gang Mei, Yifan Zhang, Qian Wan, Luoying Zhang, Lili Che. Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation. Cell death and differentiation. 2023-04-07. PMID:37029304. |
further investigations suggest that bmal1 is the direct transcriptional activator of prolyl 4-hydroxylase subunit alpha 1 (p4ha1) in chondrocytes, which orchestrates collagen prolyl hydroxylation and secretion. |
2023-04-07 |
2023-08-14 |
Not clear |
| Wenbin Gou, Yongqiang Yang, Qiuyue Shan, Shengqiang Xia, Yuqing M. P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression. Pathology international. 2023-02-03. PMID:36734588. |
although prolyl 4-hydroxylase alpha polypeptide i (p4ha1) is involved in various human malignancies, the function of p4ha1 in ec remains unclear. |
2023-02-03 |
2023-08-14 |
human |
| Xiaopeng Cao, Yi Cao, Hui Zhao, Pengfei Wang, Ziman Zh. Prolyl 4-hydroxylase P4HA1 mediates the interplay between glucose metabolism and stemness in pancreatic cancer cells. Current stem cell research & therapy. 2022-08-31. PMID:36043766. |
previously, we revealed that prolyl 4-hydroxylase subunit alpha 1 (p4ha1) enhances the warburg effect and tumor growth in pdac. |
2022-08-31 |
2023-08-14 |
Not clear |
| Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang Yang, Hongjing Zang, Qiuyuan Wen, Yajie Zhang, Songqing Fa. Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma. Journal of Cancer. vol 12. issue 22. 2021-10-22. PMID:34659558. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) is the core active catalytic portion of prolyl 4-hydroxylase, and has contributed to tumorigenesis in several cancers. |
2021-10-22 |
2023-08-13 |
Not clear |
| Sumit Agarwal, Michael Behring, Hyung-Gyoon Kim, Prachi Bajpai, Balabhadrapatruni V S K Chakravarthi, Nirzari Gupta, Amr Elkholy, Sameer Al Diffalha, Sooryanarayana Varambally, Upender Mann. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Translational oncology. vol 13. issue 4. 2021-09-24. PMID:32199274. |
here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide i (p4ha1), which is involved in collagen synthesis and deposition, had elevated expression in colorectal cancers (crcs) as compared to normal colonic tissues. |
2021-09-24 |
2023-08-13 |
mouse |
| Zhili Hu, Fang Song, Yangzhi Hu, Tianyou Lia. Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis. BioMed research international. vol 2020. 2021-09-10. PMID:33415167. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) plays a crucial role in modulating extracellular matrix component and promoting tumor progression by changing tumor adhesion, migration, and other biological behaviors in some cancers. |
2021-09-10 |
2023-08-13 |
Not clear |
| Xianxian Li, Shanshan Zhang, Yongtao Zhang, Pengchao Liu, Mian Li, Yanqin Lu, Jinxiang Ha. Myoblast differentiation of C2C12 cell may related with oxidative stress. Intractable & rare diseases research. vol 10. issue 3. 2021-09-03. PMID:34466339. |
the expression of hypoxia inducible factor1-alpha (hif1-α), hypoxia inducible factor1-beta (hif1-β), von hippel-lindau (vhl), lysyl oxidase (lox), egl-9 family hypoxia-inducible factor 1 (egln1), proline 4-hydroxylase alpha 1 (p4ha1) and heme oxygenase-1 (homx1) in the process of myoblast differentiation was verified by |
2021-09-03 |
2023-08-13 |
Not clear |
| Alyncia D Robinson, Balabhadrapatruni V S K Chakravarthi, Sumit Agarwal, Darshan Shimoga Chandrashekar, Mackenzie L Davenport, Guoan Chen, Upender Manne, David G Beer, Mick D Edmonds, Sooryanarayana Varamball. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Translational oncology. vol 14. issue 8. 2021-06-25. PMID:34049151. |
our analyses indicated that the collagen-modifying enzyme prolyl 4-hydroxylase subunit alpha 1 (p4ha1) is overexpressed in nsclc. |
2021-06-25 |
2023-08-13 |
Not clear |
| b' Johanna Eriksson, Vadim Le Joncour, Tiina Jahkola, Susanna Juteau, Pirjo Laakkonen, Olli Saksela, Erkki H\\xc3\\xb6ltt\\xc3\\xa. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. Molecular oncology. vol 14. issue 4. 2021-02-01. PMID:32053263.' |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. |
2021-02-01 |
2023-08-13 |
Not clear |
| b' Johanna Eriksson, Vadim Le Joncour, Tiina Jahkola, Susanna Juteau, Pirjo Laakkonen, Olli Saksela, Erkki H\\xc3\\xb6ltt\\xc3\\xa. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. Molecular oncology. vol 14. issue 4. 2021-02-01. PMID:32053263.' |
we studied further the significance of one of the genes, prolyl 4-hydroxylase subunit alpha 1 (p4ha1), in melanoma progression. |
2021-02-01 |
2023-08-13 |
Not clear |
| Qun Li, Zhisen Shen, Zhenhua Wu, Yi Shen, Hongxia Deng, Chongchang Zhou, Huigao Li. High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent-free survival in head and neck squamous cell carcinoma. Journal of clinical laboratory analysis. vol 34. issue 3. 2020-12-17. PMID:31782831. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) plays a critical role in modulating the extracellular matrix and promoting tumor progression in various cancers. |
2020-12-17 |
2023-08-13 |
Not clear |
| Atsushi Tanaka, Yihua Zhou, Jinru Shia, Fiona Ginty, Makiko Ogawa, David S Klimstra, Ronald C Hendrickson, Julia Y Wang, Michael H Roehr. Prolyl 4-hydroxylase alpha 1 protein expression risk-stratifies early stage colorectal cancer. Oncotarget. vol 11. issue 8. 2020-08-27. PMID:32166002. |
global proteomic profiling with fourier transform liquid chromatography-mass spectrometry sequencing and label free quantitation uncovered that p4ha1 (prolyl 4-hydroxylase alpha 1) was overexpressed in crc relative to benign colonic mucosa. |
2020-08-27 |
2023-08-13 |
Not clear |
| X P Cao, Y Cao, W J Li, H H Zhang, Z M Zh. P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer. Biochemical and biophysical research communications. vol 516. issue 3. 2020-07-06. PMID:31239153. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) is the active catalytic component of prolyl 4-hydroxylase and has been reported to promote tumor progression in several cancers. |
2020-07-06 |
2023-08-13 |
Not clear |
| Gaofeng Xiong, Rachel L Stewart, Jie Chen, Tianyan Gao, Timothy L Scott, Luis M Samayoa, Kathleen O'Connor, Andrew N Lane, Ren X. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. Nature communications. vol 9. issue 1. 2019-01-09. PMID:30367042. |
by modulating alpha ketoglutarate (α-kg) and succinate levels p4ha1 expression reduces proline hydroxylation on hypoxia-inducible factor (hif) 1α, enhancing its stability in cancer cells. |
2019-01-09 |
2023-08-13 |
Not clear |
| Gaofeng Xiong, Rachel L Stewart, Jie Chen, Tianyan Gao, Timothy L Scott, Luis M Samayoa, Kathleen O'Connor, Andrew N Lane, Ren X. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. Nature communications. vol 9. issue 1. 2019-01-09. PMID:30367042. |
here, we show that p4h alpha 1 subunit (p4ha1) protein expression is induced in triple-negative breast cancer (tnbc) and her2 positive breast cancer. |
2019-01-09 |
2023-08-13 |
Not clear |
| Wan-Ming Hu, Ji Zhang, Shu-Xin Sun, Shao-Yan Xi, Zhi-Jie Chen, Xiao-Bing Jiang, Fu-Hua Lin, Zheng-He Chen, Yin-Sheng Chen, Jian Wang, Qun-Ying Yang, Cheng-Cheng Guo, Yong-Gao Mou, Zhong-Ping Chen, Jing Zeng, Ke Sa. Identification of P4HA1 as a prognostic biomarker for high-grade gliomas. Pathology, research and practice. vol 213. issue 11. 2018-08-01. PMID:28964577. |
prolyl 4-hydroxylase subunit alpha 1 (p4ha1) is the active catalytic component of prolyl 4-hydroxylase and plays a crucial role in modulating extracellular matrix hemostasis. |
2018-08-01 |
2023-08-13 |
Not clear |
| Jun Zhang, Qian Wang, Xing Zhao, Laidi Wang, Xingguo Wang, Jian Wang, Biao Dong, Daoqing Gon. MicroRNA-122 targets genes related to goose fatty liver. Poultry science. vol 97. issue 2. 2018-07-17. PMID:29182758. |
we found that mir-122 was highly expressed in goose liver and its expression was down-regulated after overfeeding; some genes related to lipid metabolism, including prolyl 4-hydroxylase subunit alpha 1 (p4ha1); aldolase, fructose-bisphosphate b (aldob); and pyruvate kinase, muscle (pkm2), were predicted and validated as target genes of goose mir-122. |
2018-07-17 |
2023-08-13 |
Not clear |
| Balabhadrapatruni V S K Chakravarthi, Satya Sreehari Pathi, Moloy T Goswami, Marcin Cieślik, Heng Zheng, Sivakumar Nallasivam, Subramanyeswara R Arekapudi, Xiaojun Jing, Javed Siddiqui, Jyoti Athanikar, Shannon L Carskadon, Robert J Lonigro, Lakshmi P Kunju, Arul M Chinnaiyan, Nallasivam Palanisamy, Sooryanarayana Varamball. The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. Oncotarget. vol 5. issue 16. 2015-06-03. PMID:25115393. |
one of the isoforms of p4ha, prolyl 4-hydroxylase, alpha polypeptide i (p4ha1), catalyzes the formation of 4-hydroxyproline that is essential for the proper three-dimensional folding of newly synthesized procollagen chains. |
2015-06-03 |
2023-08-13 |
mouse |