| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Joana Pinto, Lucy Bizien, Julie M J Fabre, Nina Ðukanović, Valentin Lepetz, Fiona Henderson, Marine Pujol, Romain W Sala, Thibault Tarpin, Daniela Popa, Antoine Triller, Clément Léna, Véronique Fabre, Alain Bessi. Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves. The Journal of cell biology. vol 223. issue 7. 2024-05-02. PMID:38695719. |
we reveal an activity-dependent regulation of cortical inhibitory synapses by microglia, driven by purinergic signaling acting on p2rx7 and mediated by microglia-derived tnfα. |
2024-05-02 |
2024-05-04 |
Not clear |
| Kelsey Heavener, Khushbu Kabra, Maedot Yidenk, Elizabeth Bradsha. IL-1RA Disrupts ATP Activation of P2RX7 in Human Monocyte-Derived Microglia-like Cells. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645234. |
here, we utilize a human monocyte-derived microglia-like cell (mdmi) model to interrogate p2rx7 activation and downstream consequences on microglia function. |
2024-04-22 |
2024-04-24 |
human |
| Kelsey Heavener, Khushbu Kabra, Maedot Yidenk, Elizabeth Bradsha. IL-1RA Disrupts ATP Activation of P2RX7 in Human Monocyte-Derived Microglia-like Cells. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645234. |
p2rx7 expression is enriched in microglia, and elevated levels are found in microglia surrounding amyloid-beta plaques in the brain. |
2024-04-22 |
2024-04-24 |
human |
| Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikez. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:32811520. |
p2x purinoceptor 7 (p2rx7) is an atp-gated cation channel, enriched in microglia and triggers exosome secretion. |
2021-08-26 |
2023-08-13 |
mouse |
| Alba Jimenez-Pacheco, Miguel Diaz-Hernandez, Marina Arribas-Blázquez, Amaya Sanz-Rodriguez, Luis A Olivos-Oré, Antonio R Artalejo, Mariana Alves, Michael Letavic, M Teresa Miras-Portugal, Ronan M Conroy, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Anindya Bhattacharya, Tobias Engel, David C Henshal. Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 22. 2017-07-06. PMID:27251615. |
using a reporter mouse in which green fluorescent protein is induced in response to the transcription of p2rx7, we show that expression of the receptor is selectively increased in ca1 pyramidal and dentate granule neurons, as well as in microglia in mice that developed epilepsy after intra-amygdala kainic acid-induced status epilepticus. |
2017-07-06 |
2023-08-13 |
mouse |
| Huan Wang, Ling-Juan Hong, Ji-Yun Huang, Quan Jiang, Rong-Rong Tao, Chao Tan, Nan-Nan Lu, Cheng-Kun Wang, Muhammad M Ahmed, Ying-Mei Lu, Zhi-Rong Liu, Wei-Xing Shi, En-Yin Lai, Christopher S Wilcox, Feng Ha. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell research. vol 25. issue 6. 2016-03-04. PMID:25998681. |
inhibition of the p2rx7 pathway not only decreased endothelial icam-1 expression and leukocyte adhesion but also prevented microglia overactivation, reduced brain injury, and consequently doubled the early survival of septic mice. |
2016-03-04 |
2023-08-13 |
mouse |
| Rómeó D Andó, Beáta Sperlág. The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain. Brain research bulletin. vol 93. 2013-09-19. PMID:23047057. |
the expression of the purinergic ligand gated ion channel p2x7 receptor (p2rx7) has been described on nerve terminals as well as in non-neuronal cells, such as astrocytes and microglia. |
2013-09-19 |
2023-08-12 |
mouse |
| Ben J Gu, Paul N Baird, Kirstan A Vessey, Kristen K Skarratt, Erica L Fletcher, Stephen J Fuller, Andrea J Richardson, Robyn H Guymer, James S Wile. A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 4. 2013-06-17. PMID:23303206. |
these results demonstrate that a haplotype including two rare variants in p2rx7 and p2rx4 confers a functional interaction between these two variant receptors that impairs the normal scavenger function of macrophages and microglia. |
2013-06-17 |
2023-08-12 |
human |