| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deniz Önal, Hilal Korkmaz, Gizem Önal, Bilge Pehlivanoğl. Body Weight Modulates the Impact of Oxytocin on Chronic Cold-Immobilization Stress Response. Peptides. 2024-03-31. PMID:38555975. |
while oxtr expression levels in the prefrontal cortex did not vary according to the body weight and oxytocin application, oxtr levels in the hypothalamus were higher in the hfd- and/or oxytocin-treated animals. |
2024-03-31 |
2024-04-03 |
rat |
| Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Che. Electroacupuncture Ameliorates Hypothalamic‒Pituitary‒Adrenal Axis Dysfunction Induced by Surgical Trauma in Mice Through the Hypothalamic Oxytocin System. Neurochemical research. 2023-07-12. PMID:37436613. |
moreover, ea treatment reversed the ht-induced downregulation of oxytocin (oxt) and oxytocin receptor (oxtr) in the hypothalamus. |
2023-07-12 |
2023-08-14 |
mouse |
| D E Olazábal, N Pillay, N Sandberg, K-J Hartma. Description and comparison of brain distribution of oxytocin receptors in Rhabdomys pumillio and Rhabdomys dilectus. General and comparative endocrinology. 2023-01-26. PMID:36702289. |
sex differences were found in the medial preoptic area and ventral region of the lateral septum in r. pumilio (oxtr density higher in males) and in the anterior paraventricular thalamic nucleus, ventromedial nucleus of the hypothalamus and basolateral amygdala of r. dilectus (oxtr density higher in females). |
2023-01-26 |
2023-08-14 |
mouse |
| Christina N Rogers Flattery, Daniel J Coppeto, Kiyoshi Inoue, James K Rilling, Todd M Preuss, Larry J Youn. Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species. Brain structure & function. 2021-09-23. PMID:34482474. |
oxtr binding was detected in the lateral septum, hypothalamus, medial amygdala, and substantia nigra. |
2021-09-23 |
2023-08-13 |
human |
| Avery Runyan, Dana Lengel, Jimmy W Huh, Jessica R Barson, Ramesh Raghupath. Intranasal Administration of Oxytocin Attenuates Social Recognition Deficits and Increases Prefrontal Cortex Inhibitory Postsynaptic Currents following Traumatic Brain Injury. eNeuro. vol 8. issue 3. 2021-07-02. PMID:34035071. |
whereas tbi did not affect the expression of oxytocin (oxt) or the oxt receptor (oxtr) mrnas in the hypothalamus and mpfc, respectively, intranasal administration of oxt before behavioral testing was found to reduce impairments in social novelty recognition and increase ipsc frequency in the mpfc in brain-injured animals. |
2021-07-02 |
2023-08-13 |
rat |
| Radhika Vaidyanathan, Elizabeth A D Hammoc. Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6J mice in a sex- and age-dependent manner. Journal of neuroendocrinology. vol 32. issue 2. 2021-05-12. PMID:31845417. |
because developmental oxt mrna expression is enhanced by sensory-rich early life experience and reduced by sensory deprivation, we predicted that compared to wild-type (wt) littermates, mice with congenital loss of oxtr (oxtr ko), as a genetically induced deprivation, would show impaired oxt mrna expression in the offspring hypothalamus during development. |
2021-05-12 |
2023-08-13 |
mouse |
| Radhika Vaidyanathan, Elizabeth A D Hammoc. Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6J mice in a sex- and age-dependent manner. Journal of neuroendocrinology. vol 32. issue 2. 2021-05-12. PMID:31845417. |
oxt mrna levels of male and female oxtr ko mice were not different from wt littermates from postnatal day (p)0 to p6, although, by p8, oxtr ko showed significantly decreased oxt mrna expression in the hypothalamus compared to wt littermates. |
2021-05-12 |
2023-08-13 |
mouse |
| Andrea Caria, Luciana Ciringione, Simona de Falc. Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders. Brain sciences. vol 10. issue 7. 2020-09-28. PMID:32650534. |
this review aims to provide a critical synthesis of evidences linking alterations of the hypothalamus with impaired social cognition and behavior in asd by integrating results of both anatomical and functional studies in individuals with asd as well as in healthy carriers of oxytocin receptor (oxtr) genetic risk variant for asd. |
2020-09-28 |
2023-08-13 |
Not clear |
| Vinícius Elias de Moura Oliveira, Inga D Neumann, Trynke R de Jon. Post-weaning social isolation exacerbates aggression in both sexes and affects the vasopressin and oxytocin system in a sex-specific manner. Neuropharmacology. vol 156. 2020-06-10. PMID:30664846. |
furthermore, pwsi increased oxt mrna expression in the paraventricular nucleus of the hypothalamus (pvn) and decreased oxtr binding in the anterior portion of the nucleus accumbens (nacc), independent of the sex. |
2020-06-10 |
2023-08-13 |
rat |
| Virginia Meneghini Lazzari, Josi Maria Zimmermann-Peruzatto, Grasiela Agnes, Roberta Oriques Becker, Ana Carolina de Moura, Silvana Almeida, Renata Padilha Guedes, Marcia Giovenard. Hippocampal gene expression patterns in oxytocin male knockout mice are related to impaired social interaction. Behavioural brain research. vol 364. 2020-02-13. PMID:29102591. |
in this study, we evaluated the expression levels of the ot receptor (oxtr), avp receptors 1a and 1b (avpr1a; avpr1b), dopamine receptor 2 (drd2), and the estrogen receptors alpha and beta (esr1; esr2) genes in the hippocampus (hpc), olfactory bulb (ob), hypothalamus (hpt) and prefrontal cortex (pfc). |
2020-02-13 |
2023-08-13 |
mouse |
| Wesley D Frey, Kaustubh Sharma, Terri L Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Ki. Oxytocin receptor is regulated by Peg3. PloS one. vol 13. issue 8. 2019-02-04. PMID:30106994. |
in nursing female mice, removal of peg3 resulted in the increased expression of oxtr in mammary epithelial cells and also in the hypothalamus. |
2019-02-04 |
2023-08-13 |
mouse |
| Marta Maria Nowacka-Chmielewska, Daniela Kasprowska-Liśkiewicz, Jarosław Jerzy Barski, Ewa Obuchowicz, Andrzej Małeck. The behavioral and molecular evaluation of effects of social instability stress as a model of stress-related disorders in adult female rats. Stress (Amsterdam, Netherlands). vol 20. issue 6. 2018-06-15. PMID:28911267. |
hence, expression of pomc (pro-opiomelanocortin), avpr1a (arginine vasopressin receptor), and oxtr (oxytocin receptor) significantly increased in the amygdala following csis, while in pfc and/or hypothalamus, pomc, avpr1a, avpr1b, oxtr, and erβ (estrogen receptor beta) expression decreased. |
2018-06-15 |
2023-08-13 |
rat |
| Alexandra N Garcia, Christina K Depena, Weiling Yin, Andrea C Gor. Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats. Molecular and cellular endocrinology. vol 419. 2016-10-06. PMID:26454088. |
our focus was genes in the rat hypothalamus involved in social and affiliative behaviors that change with aging and/or estradiol (e2): avp, avpr1a, oxt, oxtr, and esr2 in the paraventricular nucleus (pvn) and supraoptic nucleus (son). |
2016-10-06 |
2023-08-13 |
rat |
| Daniel E Olazábal, Marcela Alsina-Llane. Are age and sex differences in brain oxytocin receptors related to maternal and infanticidal behavior in naïve mice? Hormones and behavior. vol 77. 2016-09-15. PMID:25910577. |
adult females had higher oxtr density in the ventromedial nucleus/postero-ventral hypothalamus (vmh) and the accessory olfactory bulb (aob), but lower density in the ventral region of the lateral septum (lsv) than juveniles. |
2016-09-15 |
2023-08-13 |
mouse |
| Annaliese K Beery, Lisa M McEwen, Julia L MacIsaac, Darlene D Francis, Michael S Kobo. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Hormones and behavior. vol 77. 2016-09-15. PMID:26122287. |
across groups, oxtr transcript levels in the hypothalamus were associated with reduced corticosterone secretion in response to stress, congruent with the role of oxytocin signaling in this region. |
2016-09-15 |
2023-08-13 |
human |
| Annaliese K Beery, Lisa M McEwen, Julia L MacIsaac, Darlene D Francis, Michael S Kobo. Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Hormones and behavior. vol 77. 2016-09-15. PMID:26122287. |
we examined the effects of early life rearing experience via natural variation in maternal licking and grooming during the first week of life on behavior, physiology, gene expression, and epigenetic regulation of oxtr across blood and brain tissues (mononucleocytes, hippocampus, striatum, and hypothalamus). |
2016-09-15 |
2023-08-13 |
human |
| Sara A Karlsson, Erik Studer, Petronella Kettunen, Lars Westber. Neural Androgen Receptors Modulate Gene Expression and Social Recognition But Not Social Investigation. Frontiers in behavioral neuroscience. vol 10. 2016-03-25. PMID:27014003. |
the gene expression analyses of hypothalamus and amygdala indicated that oxtr, cd38, esr1, cyp19a1, ucn3, crh, and gtf2i were differentially expressed between the three groups. |
2016-03-25 |
2023-08-13 |
mouse |
| Junping Wang, Wen Qin, Bing Liu, Dawei Wang, Yunting Zhang, Tianzi Jiang, Chunshui Y. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. NeuroImage. vol 81. 2014-03-17. PMID:23684879. |
variant in oxtr gene and functional connectivity of the hypothalamus in normal subjects. |
2014-03-17 |
2023-08-12 |
human |
| Junping Wang, Wen Qin, Bing Liu, Dawei Wang, Yunting Zhang, Tianzi Jiang, Chunshui Y. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. NeuroImage. vol 81. 2014-03-17. PMID:23684879. |
our findings identify gender-dependent mechanisms of oxtr rs53576 gene variation impacting the functional connectivity of the hypothalamus in healthy individuals and suggest that these mechanisms are important for understanding asds. |
2014-03-17 |
2023-08-12 |
human |
| Yoshiyuki Kasahara, Keisuke Sato, Yuki Takayanagi, Hiroaki Mizukami, Keiya Ozawa, Shizu Hidema, Kyoung-Ha So, Teruo Kawada, Nao Inoue, Ikuo Ikeda, Sang-Gun Roh, Keiichi Itoi, Katsuhiko Nishimor. Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology. vol 154. issue 11. 2014-01-08. PMID:24002032. |
here we demonstrate that the oxtr in the hypothalamus has important functions in thermoregulation. |
2014-01-08 |
2023-08-12 |
mouse |