| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuo Nakazawa, Minako Matsuo, Yo Kikuchi, Yoshihiro Nakajima, Rika Numan. Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock. Frontiers in neuroscience. vol 18. 2024-05-02. PMID:38694901. |
herein, we screened for dna aptamer of melanopsin (opn4), a blue-light photopigment in the retina, which plays a key role using light signals to reset the phase of circadian rhythms in the central clock. |
2024-05-02 |
2024-05-04 |
Not clear |
| Shu K E Tam, Laurence A Brown, Tatiana S Wilson, Selma Tir, Angus S Fisk, Carina A Pothecary, Vincent van der Vinne, Russell G Foster, Vladyslav V Vyazovskiy, David M Bannerman, Mary E Harrington, Stuart N Peirso. Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 39. 2021-10-07. PMID:34556572. |
in addition to rods and cones, the retina contains a small population of photosensitive retinal ganglion cells (prgcs) expressing the photopigment melanopsin (opn4). |
2021-10-07 |
2023-08-13 |
mouse |
| Mario E Guido, Natalia A Marchese, Maximiliano N Rios, Luis P Morera, Nicolás M Diaz, Eduardo Garbarino-Pico, María Ana Conti. Non-visual Opsins and Novel Photo-Detectors in the Vertebrate Inner Retina Mediate Light Responses Within the Blue Spectrum Region. Cellular and molecular neurobiology. 2020-11-24. PMID:33231827. |
it is now known that the vertebrate retina is composed of visual photoreceptor cones and rods responsible for diurnal/color and nocturnal/black and white vision, and cells like the intrinsically photosensitive retinal ganglion cells (iprgcs) and photosensitive horizontal cells in the inner retina, both detecting blue light and expressing the photopigment melanopsin (opn4). |
2020-11-24 |
2023-08-13 |
Not clear |
| Charlene Hanlon, Ramesh Ramachandran, Martin J Zuidhof, Grégoy Y Bédécarrat. Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens. Frontiers in physiology. vol 11. 2020-09-28. PMID:32670092. |
while photoreceptors are present in the retina of the eye and the pineal gland, it is the deep brain photoreceptors (dbps) located in the hypothalamus that have been identified as the potential mediators of photostimulation, including melanopsin (opn4), neuropsin (opn5), and vertebrate-ancient opsin (va-opsin). |
2020-09-28 |
2023-08-13 |
Not clear |
| Dinesh Kankanamge, Kasun Ratnayake, Saroopa Samaradivakara, Ajith Karunarathn. Melanopsin (Opn4) utilizes Gα Journal of cell science. vol 131. issue 11. 2019-10-25. PMID:29712722. |
non-image-forming functions of opn4 not only regulate circadian behavior, but also control growth and development processes of the retina. |
2019-10-25 |
2023-08-13 |
Not clear |
| Maria Nathália Moraes, Leonardo Vinícius Monteiro de Assis, Keila Karoline Magalhães-Marques, Maristela Oliveira Poletini, Leonardo Henrique Ribeiro Graciani de Lima, Ana Maria de Lauro Castrucc. Melanopsin, a Canonical Light Receptor, Mediates Thermal Activation of Clock Genes. Scientific reports. vol 7. issue 1. 2019-07-18. PMID:29070825. |
melanopsin (opn4) is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (iprgcs) of the mammalian retina. |
2019-07-18 |
2023-08-13 |
mouse |
| Luis P Morera, Nicolás M Díaz, Mario E Guid. Horizontal cells expressing melanopsin x are novel photoreceptors in the avian inner retina. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 46. 2018-04-27. PMID:27789727. |
in the chicken retina, both opn4 proteins are found in iprgcs, and opn4x is also present in retinal horizontal cells (hcs), which connect with visual photoreceptors. |
2018-04-27 |
2023-08-13 |
chicken |
| Juuso S Nissilä, Satu K Mänttäri, Terttu T Särkioja, Hannu J Tuominen, Timo E Takala, Vesa J Kiviniemi, Raija T Sormunen, Seppo Y O Saarela, Markku J Timone. The distribution of melanopsin (OPN4) protein in the human brain. Chronobiology international. vol 34. issue 1. 2018-01-18. PMID:27690288. |
until now, melanopsin (opn4) - a specialized photopigment being responsive especially to blue light wavelengths - has not been found in the human brain at protein level outside the retina. |
2018-01-18 |
2023-08-13 |
human |
| M M Lira-Carrera, B E Gutiérrez-Amavizca, L J Álvarez-Araujo, M Aguirre-Ramírez, J A Pérez-Leó. Analysis of melanopsin gene expression in the rabbit retina at different ages. Genetics and molecular research : GMR. vol 16. issue 3. 2017-12-22. PMID:28973746. |
this is the first report describing opn4 gene expression in the rabbit retina at different ages. |
2017-12-22 |
2023-08-13 |
rabbit |
| Nicolás M Díaz, Luis P Morera, Mario E Guid. Melanopsin and the Non-visual Photochemistry in the Inner Retina of Vertebrates. Photochemistry and photobiology. vol 92. issue 1. 2016-12-22. PMID:26500165. |
melanopsin (opn4), a member of the g-protein-coupled receptor family, is a vitamin a-based opsin in the vertebrate retina that has been shown to be involved in the synchronization of circadian rhythms, pupillary light reflexes, melatonin suppression and other light-regulated tasks. |
2016-12-22 |
2023-08-13 |
xenopus_laevis |
| David J Ramsey, Kathryn Moynihan Ramsey, Demetrios G Vavva. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Seminars in ophthalmology. vol 28. issue 5-6. 2014-04-25. PMID:24010846. |
in humans, the visual system is integral to photoentrainment and is primarily driven by a specialized class of intrinsically photosensitive retinal ganglion cells (iprgcs) that express the photopigment melanopsin (opn4) in the inner retina. |
2014-04-25 |
2023-08-12 |
Not clear |
| Ming-Feng Zou, Lin Bai, Bo Kang, Xue-Wei L. [cDNA cloning and expression analysis of Opn4 gene in retina of swines]. Yi chuan = Hereditas. vol 35. issue 7. 2013-09-19. PMID:23853360. |
[cdna cloning and expression analysis of opn4 gene in retina of swines]. |
2013-09-19 |
2023-08-12 |
Not clear |
| Ming-Feng Zou, Lin Bai, Bo Kang, Xue-Wei L. [cDNA cloning and expression analysis of Opn4 gene in retina of swines]. Yi chuan = Hereditas. vol 35. issue 7. 2013-09-19. PMID:23853360. |
the mrna expression levels of opn4 gene in the retina of the swines during developmental stages and different times of the day were examined. |
2013-09-19 |
2023-08-12 |
Not clear |
| Vanessa Matos-Cruz, Joseph Blasic, Benjamin Nickle, Phyllis R Robinson, Samer Hattar, Marnie E Halper. Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PloS one. vol 6. issue 9. 2012-02-10. PMID:21966429. |
while mammals have a single melanopsin gene (opn4), zebrafish show remarkable diversity with two opn4x-related and three opn4-related genes expressed in distinct patterns in multiple neuronal cell types of the developing retina, including bipolar interneurons. |
2012-02-10 |
2023-08-12 |
xenopus_laevis |
| Daniela M Verra, Maria Ana Contín, David Hicks, Mario E Guid. Early onset and differential temporospatial expression of melanopsin isoforms in the developing chicken retina. Investigative ophthalmology & visual science. vol 52. issue 8. 2011-09-09. PMID:21676907. |
in this study, the presence of nonvisual phototransduction cascade components in the developing chicken retina and primary rgcs cultures was investigated, focusing on the two opn4 genes: the xenopus (opn4x) and the mammalian (opn4m) orthologs. |
2011-09-09 |
2023-08-12 |
chicken |
| Susana S Pires, Steven Hughes, Michael Turton, Zare Melyan, Stuart N Peirson, Lei Zheng, Maria Kosmaoglou, James Bellingham, Michael E Cheetham, Robert J Lucas, Russell G Foster, Mark W Hankins, Stephanie Halfor. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 39. 2009-10-13. PMID:19793992. |
differential expression of two distinct functional isoforms of melanopsin (opn4) in the mammalian retina. |
2009-10-13 |
2023-08-12 |
mouse |
| Susana S Pires, Steven Hughes, Michael Turton, Zare Melyan, Stuart N Peirson, Lei Zheng, Maria Kosmaoglou, James Bellingham, Michael E Cheetham, Robert J Lucas, Russell G Foster, Mark W Hankins, Stephanie Halfor. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 39. 2009-10-13. PMID:19793992. |
the distinct isoforms of opn4 described in this study provide a potential molecular basis for generating this diversity, and it seems likely that their differential expression plays a role in generating the variety of prgc light responses found in the mammalian retina. |
2009-10-13 |
2023-08-12 |
mouse |
| Stuart N Peirson, Henrik Oster, Sarah L Jones, Michael Leitges, Mark W Hankins, Russell G Foste. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Current biology : CB. vol 17. issue 16. 2007-12-06. PMID:17702581. |
within the mammalian retina, there exists a third photoreceptive system based upon a population of melanopsin (opn4) expressing photosensitive retinal ganglion cells (prgcs; also termed iprgcs or intrinsically photosensitive rgcs). |
2007-12-06 |
2023-08-12 |
Not clear |
| Michelle Fèvre-Montange, Jacques Champier, Alexandru Szathmari, Anne Wierinckx, Carmine Mottolese, Jacques Guyotat, Dominique Figarella-Branger, Anne Jouvet, Joël Lachue. Microarray analysis reveals differential gene expression patterns in tumors of the pineal region. Journal of neuropathology and experimental neurology. vol 65. issue 7. 2006-08-29. PMID:16825954. |
the pineocytomas showed high expression of tph, hiomt, and genes related to phototransduction in the retina (opn4, rgs16, and crb3), whereas the pineoblastoma showed high expression of ubec2, sox4, tert, tep1, prame, cd24, pou4f2, and hoxd13. |
2006-08-29 |
2023-08-12 |
Not clear |
| Michael J Bailey, Vincent M Casson. Melanopsin expression in the chick retina and pineal gland. Brain research. Molecular brain research. vol 134. issue 2. 2005-07-05. PMID:15836930. |
in situ hybridization (ish) revealed opn4 mrna in areas associated with phototransduction and the visual system, including the pineal gland and optic tectum of the brain, along with gcl, inner nuclear layer (inl), and photoreceptor layer (pl) of the retina. |
2005-07-05 |
2023-08-12 |
mouse |