| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ximena Corso-Díaz, Xulong Liang, Kiam Preston, Bilguun Tegshee, Milton A English, Jacob Nellissery, Sharda Prasad Yadav, Claire Marchal, Anand Swaroo. Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345562. |
our findings suggest additional functions of nrl during transcription and highlight complex interactions among transcription factors, rbps, and r-loops in regulating photoreceptor gene expression in the mammalian retina. |
2024-09-30 |
2024-10-02 |
Not clear |
| Soo-Young Kim, Christine Haewon Park, Bo-Hyun Moon, Gail K Seabol. Murine Retina Outer Plexiform Layer Development and Transcriptome Analysis of Pre-Synapses in Photoreceptors. Life (Basel, Switzerland). vol 14. issue 9. 2024-09-28. PMID:39337887. |
the transcription factor neural retina leucine zipper (nrl) determines the rod vs. cone photoreceptor cell fate and is critical for rod differentiation. |
2024-09-28 |
2024-10-01 |
Not clear |
| Dhiraj Srivastava, Pavithra Gowribidanur-Chinnaswamy, Paras Gaur, Maria Spies, Anand Swaroop, Nikolai O Artemye. Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element. Structure (London, England : 1993). 2024-07-31. PMID:39084215. |
two retinal transcription factors, cone-rod homeobox (crx) and neural retina leucine zipper (nrl), cooperate functionally and physically to control photoreceptor development and homeostasis. |
2024-07-31 |
2024-08-03 |
Not clear |
| Xulong Liang, Sharda P Yadav, Zachary A Batz, Jacob Nellissery, Anand Swaroo. Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina. Human molecular genetics. 2022-10-13. PMID:36226585. |
protein kinase ck2 modulates the activity of maf-family bzip transcription factor nrl in rod photoreceptors of mammalian retina. |
2022-10-13 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
developmental genome-wide occupancy analysis of bzip transcription factor nrl uncovers the role of c-jun in early differentiation of rod photoreceptors in the mammalian retina. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
the basic motif-leucine zipper (bzip) transcription factor nrl determines rod photoreceptor cell fate during retinal development, and its loss leads to cone-only retina in mice. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
nrl works synergistically with homeodomain protein crx and other regulatory factors to control the transcription of most genes associated with rod morphogenesis and functional maturation, which span over a period of several weeks in the mammalian retina. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
coimmunoprecipitation studies showed association of nrl with c-jun, also a bzip protein, in transfected cells as well as in developing mouse retina. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
additionally, shrna-mediated knockdown of c-jun in the mouse retina in vivo resulted in altered expression of almost 1000 genes, with reduced expression of phototransduction genes and many direct targets of nrl in rod photoreceptors. |
2022-07-01 |
2023-08-14 |
mouse |
| Fei Liu, Yayun Qin, Yuwen Huang, Pan Gao, Jingzhen Li, Shanshan Yu, Danna Jia, Xiang Chen, Yuexia Lv, Jiayi Tu, Kui Sun, Yunqiao Han, James Reilly, Xinhua Shu, Qunwei Lu, Zhaohui Tang, Chengqi Xu, Daji Luo, Mugen Li. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS genetics. vol 18. issue 3. 2022-03-04. PMID:35245286. |
neural retina leucine zipper (nrl) is an essential gene for the fate determination and differentiation of the precursor cells into rod photoreceptors in mammals. |
2022-03-04 |
2023-08-13 |
zebrafish |
| Fei Liu, Yayun Qin, Yuwen Huang, Pan Gao, Jingzhen Li, Shanshan Yu, Danna Jia, Xiang Chen, Yuexia Lv, Jiayi Tu, Kui Sun, Yunqiao Han, James Reilly, Xinhua Shu, Qunwei Lu, Zhaohui Tang, Chengqi Xu, Daji Luo, Mugen Li. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS genetics. vol 18. issue 3. 2022-03-04. PMID:35245286. |
through bulk and single-cell rna sequencing, we characterized the gene expression profiles of the whole retina and each retinal cell type from the wild type and nrl knockout zebrafish. |
2022-03-04 |
2023-08-13 |
zebrafish |
| Jing Wang, Yu-Ping Liang, Jin-Dong Zhu, Yu-Xi Wang, Meng-Ya Yang, Hong-Ru Yan, Qian-Yi Lv, Kai Cheng, Xiang Zhao, Xiao Zhan. Phototropin 1 Mediates High-Intensity Blue Light-Induced Chloroplast Accumulation Response in a Root Phototropism 2-Dependent Manner in Frontiers in plant science. vol 12. 2021-10-15. PMID:34646282. |
in contrast, rpt2 functions redundantly with neural retina leucine zipper (nrl) protein for chloroplast movement 1 (nch1) under low-light irradiation. |
2021-10-15 |
2023-08-13 |
Not clear |
| Elisa Cuevas, Daniel L Holder, Ashwak H Alshehri, Julie Tréguier, Jörn Lakowski, Jane C Sowde. NRL Stem cells (Dayton, Ohio). vol 39. issue 4. 2021-09-19. PMID:33400844. |
nrl organoid cultures represent a unique tool to investigate the developmental complexity of tissues like the human retina. |
2021-09-19 |
2023-08-13 |
mouse |
| Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marig. New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa. International journal of molecular sciences. vol 22. issue 12. 2021-07-19. PMID:34208617. |
661w cells were genetically modified to stably express the neural retina leucine zipper (nrl) transcription factor. |
2021-07-19 |
2023-08-13 |
Not clear |
| Alyssa Kallman, Elizabeth E Capowski, Jie Wang, Aniruddha M Kaushik, Alex D Jansen, Kimberly L Edwards, Liben Chen, Cynthia A Berlinicke, M Joseph Phillips, Eric A Pierce, Jiang Qian, Tza-Huei Wang, David M Gamm, Donald J Zac. Investigating cone photoreceptor development using patient-derived NRL null retinal organoids. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32081919. |
neural retina leucine zipper (nrl) is critical for rod photoreceptor genesis and degeneration, with nrl mutations known to cause enhanced s-cone syndrome and retinitis pigmentosa. |
2021-06-17 |
2023-08-13 |
human |
| A Phillip Oel, Gavin J Neil, Emily M Dong, Spencer D Balay, Keon Collett, W Ted Alliso. Nrl Is Dispensable for Specification of Rod Photoreceptors in Adult Zebrafish Despite Its Deeply Conserved Requirement Earlier in Ontogeny. iScience. vol 23. issue 12. 2020-12-11. PMID:33299975. |
the transcription factor nrl (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell fate in the retina. |
2020-12-11 |
2023-08-13 |
mouse |
| Spencer M Moore, Dorota Skowronska-Krawczyk, Daniel L Cha. Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa. Journal of clinical medicine. vol 9. issue 7. 2020-09-28. PMID:32668775. |
multiple groups have demonstrated that inhibition of nrl or nr2e3 activity in the mature retina could endow rods with certain properties of cones, which prevents cell death in multiple rodent rp models with diverse mutations. |
2020-09-28 |
2023-08-13 |
Not clear |
| Christie K Campla, Hannah Mast, Lijin Dong, Jingqi Lei, Stephanie Halford, Sumathi Sekaran, Anand Swaroo. Targeted deletion of an NRL- and CRX-regulated alternative promoter specifically silences FERM and PDZ domain containing 1 (Frmpd1) in rod photoreceptors. Human molecular genetics. vol 28. issue 5. 2020-03-11. PMID:30445545. |
a proximal promoter sequence (-8 to +33 bp) of frmpd1 binds to neural retina leucine zipper (nrl) and cone-rod homeobox protein (crx), two rod-specific differentiation factors, and is necessary for activating reporter gene expression in vitro and in vivo. |
2020-03-11 |
2023-08-13 |
mouse |
| Juthaporn Assawachananont, Soo-Young Kim, Koray D Kaya, Robert Fariss, Jerome E Roger, Anand Swaroo. Cone-rod homeobox CRX controls presynaptic active zone formation in photoreceptors of mammalian retina. Human molecular genetics. vol 27. issue 20. 2019-05-20. PMID:30084954. |
while neural retina leucine zipper (nrl) transcription factor determines rod cell fate and function, cone-rod homeobox (crx) controls the expression of both rod- and cone-specific genes and is critical for terminal differentiation of photoreceptors. |
2019-05-20 |
2023-08-13 |
mouse |
| Yang Kong, Lihong Zhao, Jeremy R Charette, Wanda L Hicks, Lisa Stone, Patsy M Nishina, Jürgen K Nagger. An FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency. Human molecular genetics. vol 27. issue 19. 2019-03-28. PMID:29947801. |
photoreceptor dysplasia, characterized by formation of folds and (pseudo-)rosettes in the outer retina, is associated with loss of functional nuclear receptor subfamily 2 group e member 3 (nr2e3) and neural retina leucine-zipper (nrl) in both humans and mice. |
2019-03-28 |
2023-08-13 |
mouse |