| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ximena Corso-Díaz, Xulong Liang, Kiam Preston, Bilguun Tegshee, Milton A English, Jacob Nellissery, Sharda Prasad Yadav, Claire Marchal, Anand Swaroo. Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345562. |
using affinity purification, yeast-two-hybrid and proximity ligation assays, we identified interactions of multiple rbps with nrl, a maf-family bzip transcription factor critical for retinal rod photoreceptor development and function. |
2024-09-30 |
2024-10-02 |
Not clear |
| Soo-Young Kim, Christine Haewon Park, Bo-Hyun Moon, Gail K Seabol. Murine Retina Outer Plexiform Layer Development and Transcriptome Analysis of Pre-Synapses in Photoreceptors. Life (Basel, Switzerland). vol 14. issue 9. 2024-09-28. PMID:39337887. |
the transcription factor neural retina leucine zipper (nrl) determines the rod vs. cone photoreceptor cell fate and is critical for rod differentiation. |
2024-09-28 |
2024-10-01 |
Not clear |
| Dominic W H Shayler, Kevin Stachelek, Linda Cambier, Sunhye Lee, Jinlun Bai, Mark W Reid, Daniel J Weisenberger, Bhavana Bhat, Jennifer G Aparicio, Yeha Kim, Mitali Singh, Maxwell Bay, Matthew E Thornton, Eamon K Doyle, Zachary Fouladian, Stephan G Erberich, Brendan H Grubbs, Michael A Bonaguidi, Cheryl Mae Craft, Hardeep P Singh, David Cobrini. Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38915659. |
the analyses revealed early post-mitotic cone- and rod-directed populations characterized by higher thrb or nrl regulon activities, an immature photoreceptor precursor population with concurrent cone and rod gene and regulon expression, and distinct early and late cone and rod maturation states distinguished by maturation-associated declines in rax regulon activity. |
2024-06-25 |
2024-06-27 |
human |
| Gavin J Neil, Kaitlyn H Kluttig, W Ted Alliso. Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl. Investigative ophthalmology & visual science. vol 65. issue 1. 2024-01-23. PMID:38261312. |
determining photoreceptor cell identity: rod versus cone fate governed by tbx2b opposing nrl. |
2024-01-23 |
2024-01-25 |
zebrafish |
| Gavin J Neil, Kaitlyn H Kluttig, W Ted Alliso. Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl. Investigative ophthalmology & visual science. vol 65. issue 1. 2024-01-23. PMID:38261312. |
disrupting nrl abrogates rod development and produces an excess of s-cones (also known as "uv cones" or "short-wavelength-sensitive1 [sws1] cones"). |
2024-01-23 |
2024-01-25 |
zebrafish |
| Chi Sun, Shiming Che. Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development. Frontiers in molecular neuroscience. vol 16. 2023-05-15. PMID:37181651. |
nrl is required for the rod fate and regulates downstream rod-specific genes including the orphan nuclear receptor nr2e3 which further activates rod-specific genes and simultaneously represses cone-specific genes. |
2023-05-15 |
2023-08-14 |
Not clear |
| Joseph Bunker, Mhamed Bashir, Sydney Bailey, Pamela Boodram, Alexis Perry, Rory Delaney, Maria Tsachaki, Simon G Sprecher, Erik Nelson, Gerald B Call, Jens Riste. Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in Frontiers in cell and developmental biology. vol 11. 2023-03-24. PMID:36960411. |
moreover, otx2 and crx promote expression of the nuclear receptor nrl that promotes rod photoreceptor fate and represses cone photoreceptor fate. |
2023-03-24 |
2023-08-14 |
Not clear |
| Yeh Chwan Leong, Valentina Di Foggia, Hema Pramod, Maria Bitner-Glindzicz, Aara Patel, Jane C Sowde. Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution. Stem cell reports. 2022-10-14. PMID:36240775. |
single-cell rna sequencing revealed myo7a expression in rod photoreceptor and müller glial cells corresponding to upregulation of stress responses in nrl |
2022-10-14 |
2023-08-14 |
Not clear |
| Xulong Liang, Sharda P Yadav, Zachary A Batz, Jacob Nellissery, Anand Swaroo. Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina. Human molecular genetics. 2022-10-13. PMID:36226585. |
protein kinase ck2 modulates the activity of maf-family bzip transcription factor nrl in rod photoreceptors of mammalian retina. |
2022-10-13 |
2023-08-14 |
mouse |
| Xulong Liang, Sharda P Yadav, Zachary A Batz, Jacob Nellissery, Anand Swaroo. Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina. Human molecular genetics. 2022-10-13. PMID:36226585. |
maf-family basic motif leucine zipper protein nrl specifies rod photoreceptor cell fate during retinal development and, in concert with homeodomain protein crx and other regulatory factors, controls the expression of most rod-expressed genes including the visual pigment gene rhodospin (rho). |
2022-10-13 |
2023-08-14 |
mouse |
| Xulong Liang, Sharda P Yadav, Zachary A Batz, Jacob Nellissery, Anand Swaroo. Protein kinase CK2 modulates the activity of Maf-family bZIP transcription factor NRL in rod photoreceptors of mammalian retina. Human molecular genetics. 2022-10-13. PMID:36226585. |
modulation of nrl activity by ck2 suggests intricate inter-dependence of transcriptional and signaling pathways in maintaining rod homeostasis. |
2022-10-13 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
developmental genome-wide occupancy analysis of bzip transcription factor nrl uncovers the role of c-jun in early differentiation of rod photoreceptors in the mammalian retina. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
the basic motif-leucine zipper (bzip) transcription factor nrl determines rod photoreceptor cell fate during retinal development, and its loss leads to cone-only retina in mice. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
nrl works synergistically with homeodomain protein crx and other regulatory factors to control the transcription of most genes associated with rod morphogenesis and functional maturation, which span over a period of several weeks in the mammalian retina. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
we predicted that nrl gradually establishes rod cell identity and function by temporal and dynamic regulation of stage-specific transcriptional targets. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
additionally, shrna-mediated knockdown of c-jun in the mouse retina in vivo resulted in altered expression of almost 1000 genes, with reduced expression of phototransduction genes and many direct targets of nrl in rod photoreceptors. |
2022-07-01 |
2023-08-14 |
mouse |
| Xulong Liang, Matthew J Brooks, Anand Swaroo. Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina. Human molecular genetics. 2022-07-01. PMID:35776116. |
we propose that c-jun-nrl heterodimers prime the nrl-directed transcriptional program in neonatal rod photoreceptors before high nrl expression suppresses c-jun at later stages. |
2022-07-01 |
2023-08-14 |
mouse |
| Xinming Zhuo, Barry E Kno. Interaction of human CRX and NRL in live HEK293T cells measured using fluorescence resonance energy transfer (FRET). Scientific reports. vol 12. issue 1. 2022-04-28. PMID:35484285. |
crx and nrl are retina-specific transcription factors that control rod photoreceptor differentiation and synergistically activate rod phototransduction gene expression. |
2022-04-28 |
2023-08-13 |
human |
| Fei Liu, Yayun Qin, Yuwen Huang, Pan Gao, Jingzhen Li, Shanshan Yu, Danna Jia, Xiang Chen, Yuexia Lv, Jiayi Tu, Kui Sun, Yunqiao Han, James Reilly, Xinhua Shu, Qunwei Lu, Zhaohui Tang, Chengqi Xu, Daji Luo, Mugen Li. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS genetics. vol 18. issue 3. 2022-03-04. PMID:35245286. |
rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. |
2022-03-04 |
2023-08-13 |
zebrafish |
| Fei Liu, Yayun Qin, Yuwen Huang, Pan Gao, Jingzhen Li, Shanshan Yu, Danna Jia, Xiang Chen, Yuexia Lv, Jiayi Tu, Kui Sun, Yunqiao Han, James Reilly, Xinhua Shu, Qunwei Lu, Zhaohui Tang, Chengqi Xu, Daji Luo, Mugen Li. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS genetics. vol 18. issue 3. 2022-03-04. PMID:35245286. |
neural retina leucine zipper (nrl) is an essential gene for the fate determination and differentiation of the precursor cells into rod photoreceptors in mammals. |
2022-03-04 |
2023-08-13 |
zebrafish |