All Relations between nox4 and Nicotine
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Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
in cardiomyocytes, nicotine significantly increased nadph oxidase 4 (nox4), which coincided with increased reactive oxygen species (ros) and increased cardiomyocyte apoptosis which were dependent on phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
Gabriel Rezonzew, Phillip Chumley, Wenguang Feng, Ping Hua, Gene P Siegal, Edgar A Jaime. Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor. American journal of physiology. Renal physiology. vol 303. issue 2. 2012-10-02. PMID:22552933. |
in 5/6nx rats, the administration of nicotine significantly increased urinary protein excretion (onefold), worsened the glomerular injury score and increased fibronectin (∼ 50%), nadph oxidase 4 (nox4; ∼100%), and transforming growth factor-β expression (∼200%). |
2012-10-02 |
2023-08-12 |
rat |