| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Yun Liu, Ling-Yan Zhang, Xiao-Yu Wang, Shi-Chao Li, Yu-Yan Hu, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhan. STAT4-Mediated Klotho Up-Regulation Contributes to the Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning via Inhibiting Neuronal Pyroptosis. Molecular neurobiology. 2023-10-24. PMID:37875707. |
firstly, the expressions of pyroptosis-associated proteins (i.e., nlrp3, gsdmd, pro-caspase-1, and cleaved caspase-1) in hippocampal ca1 region were determined during the process of brain ischemic tolerance. |
2023-10-24 |
2023-11-08 |
Not clear |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-\\xce\\xbaB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
we found that hpc decreased nlrp3 inflammasome in microglia and inhibited m1 polarization of microglia in ca1 after tgci. |
2023-09-08 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-\\xce\\xbaB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
additionally, the knockdown of p-mlkl by short hairpin rna (shrna) administration inhibited the activation of the nf-\xce\xbab signaling pathway and reduced the formation of nlrp3 inflammasome, thus attenuating m1 polarization of microglia and decreasing the release of interleukin 1 beta (il-1\xce\xb2) and necrosis factor alpha (tnf-\xce\xb1) in ca1 post ischemia. |
2023-09-08 |
2023-10-07 |
rat |
| Liu Ruilian, Zhou Hao, Qu Honglin, Chen Yilin, Bai Qingyun, Guo Fuqiang, Wang Liang, Jiang Xiaobo, Mao Haifen. Effects of aerobic exercise on depression-like behavior and TLR4/NLRP3 pathway in hippocampus CA1 region of CUMS-depressed mice. Journal of affective disorders. 2023-08-27. PMID:37634821. |
the paper observes regulation of the expression levels of nlrp3 and tlr4 in hippocampal ca1 neurons in cums mice by aerobic exercise with constructing cums depression mouse model, in order to explore the neuroprotective mechanism of aerobic exercise on the hippocampus of depressed mice. |
2023-08-27 |
2023-09-07 |
mouse |
| Sevsen Alt\\xc4\\xb1n\\xc3\\xb6z, Serap Cilaker Micili, S\\xc4\\xb1la Soy, Defne Eng\\xc3\\xbcr, Bora Baysal, Abdullah Kumra. Impact of Maternal Ketogenic Diet on NLRP3 Inflammasome Response in the Offspring Brain. Nutrients. vol 15. issue 8. 2023-04-28. PMID:37111213. |
nlrp3 and il-1\xce\xb2 were higher in the kd group than in the sd group at pn21 in the pfc, ca1 and dg regions, and were significantly lower in the dg region of the kd group especially when compared to the sd group following lps. |
2023-04-28 |
2023-08-14 |
mouse |
| Sevsen Alt\\xc4\\xb1n\\xc3\\xb6z, Serap Cilaker Micili, S\\xc4\\xb1la Soy, Defne Eng\\xc3\\xbcr, Bora Baysal, Abdullah Kumra. Impact of Maternal Ketogenic Diet on NLRP3 Inflammasome Response in the Offspring Brain. Nutrients. vol 15. issue 8. 2023-04-28. PMID:37111213. |
on the other hand, in the presence of kd exposure, nlrp3 expression after lps injection was lower in the dg and ca1 areas but not in the pfc when compared to sd group. |
2023-04-28 |
2023-08-14 |
mouse |
| Li-Min Zhang, Zhi-You Wu, Ji-Zhen Liu, Yan Li, Jin-Meng Lv, Lu-Ying Wang, Yu-Dong Shan, Rong-Xin Song, Hui-Tao Miao, Wei Zhang, Dong-Xue Zhan. Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. Journal of psychiatric research. vol 158. 2022-12-21. PMID:36542981. |
subanesthetic doses (10\xc2\xa0mg/kg) of s-ketamine have significantly mitigated depression-like behaviors, cognitive deficits and ltp impairment, reduced astrocytosis, excessive gaba, and inflammatory factors, including nlrp3 and il-18 in astrocytes in the ca1. |
2022-12-21 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
in ca1, nlrp3-positive microglia and cleaved gsdmd-positive neurons were associated with local neuronal loss, indicating a possible contribution of nlrp3 inflammasome and pyroptosis activation to ad-related neurodegeneration. |
2022-12-09 |
2023-08-14 |
human |
| Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccol\\xc3\\xb2 Terrand. Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. Frontiers in immunology. vol 13. 2022-05-23. PMID:35603196. |
surgery triggered asc specks formation in ca1 hippocampal microglia, but without inducing significant morphological changes in nlrp3 and asc knockout mice. |
2022-05-23 |
2023-08-13 |
mouse |
| Rong-Rong Qiu, Hong Zhang, Chang Deng, Dan-Feng Chen, Ya-Yu Xu, Dan Xiong, Ying-Jie Zou, Jie Ta. [Effects of electroacupuncture on ROS-NLRP3 inflammatory pathway and autophagy related proteins in hippocampus of vascular dementia rats]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 4. 2022-04-29. PMID:35486008. |
to observe the effect of electroacupuncture (ea) on learning-memory ability, ultrastructural changes of hippocampal ca1 neurons, reactive oxygen species (ros) level, nod-like receptor protein 3 (nlrp3) and auto-phagy-related proteins expression in the hippocampus of vascular dementia (vd) rats, so as to reveal its partial mechanisms in treating vd. |
2022-04-29 |
2023-08-13 |
rat |
| Di Liu, Feng Lv, Su Min, You Yang, Lihao Che. Inhibition of NLRP3 inflammasome-mediated neuroinflammation alleviates electroconvulsive shock-induced memory impairment via regulation of hippocampal synaptic plasticity in depressive rats. Behavioural brain research. 2022-04-07. PMID:35390431. |
pharmacological inhibition of nlrp3 inflammasome with mcc950 (nlrp3 inhibitor) in vivo significantly alleviated ecs-induced spatial learning and memory impairment, partially reversed neuroinflammation, and synaptic structural plasticity in the damaged hippocampal ca1 region, and reduced synapse associated protein expression and microglial activation. |
2022-04-07 |
2023-08-13 |
rat |
| Andrew J Kwilasz, Laurel S Todd, Julissa C Duran-Malle, Anouk E W Schrama, Eric H Mitten, Tracey A Larson, Madison A Clements, Kevin M Harris, Scott T Litwiler, Xiaohui Wang, Anne-Marie Van Dam, Steven F Maier, Kenner C Rice, Linda R Watkins, Ruth M Barriento. Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone. Behavioural brain research. vol 396. 2021-11-09. PMID:32905811. |
this was associated with increased mrna for hippocampal interleukin-1\xce\xb2 (il-1\xce\xb2), tlr2, tlr4, nlrp3, and il-17 and elevated expression of the microglial marker iba1 in ca1 and dg regions of the hippocampus, confirming the neuroinflammation observed in higher-dose eae models. |
2021-11-09 |
2023-08-13 |
human |
| Sihan Guo, Ruimin Wang, Jiewei Hu, Liping Sun, Xinru Zhao, Yufeng Zhao, Dong Han, Shuqun H. Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Function Recovery Involving NLRP3 Inflammasome Mitigation Following Global Cerebral Ischemia. Frontiers in cellular neuroscience. vol 15. 2021-09-08. PMID:34489645. |
photobiomodulation promotes hippocampal ca1 nsc differentiation toward neurons and facilitates cognitive function recovery involving nlrp3 inflammasome mitigation following global cerebral ischemia. |
2021-09-08 |
2023-08-13 |
rat |
| Yulia K Komleva, Olga L Lopatina, Iana V Gorina, Anton N Shuvaev, Anatoly Chernykh, Ilia V Potapenko, Alla B Salmin. NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice. Brain research. vol 1752. 2021-07-22. PMID:33358726. |
these include the following: anxious behavior and deterioration in learning and memory of fear conditioning; impairment of adult neurogenesis; reduction and altered morphology of astrocytes in the brain; hyperexcitability in basolateral amygdala (bla); impaired activation in axons of pyramidal cells of ca1 hippocampal zone in nlrp3 ko mice particularly via the schaffer collateral pathway; and impaired synaptic transduction in pyramidal cells mediated by an embarrassment of neurotransmitter release from presynaptic site in ca3 hippocampal zone. |
2021-07-22 |
2023-08-13 |
mouse |
| Xiuli Yang, Zhuoran Wang, Xiaofeng Ji. Neuroprotection of Glibenclamide against Brain Injury after Cardiac Arrest via Modulation of NLRP3 Inflammasome. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2019. 2020-05-11. PMID:31946797. |
furthermore, on the molecular basis, the nlrp3 inflammasome was strongly activated in the hippocampal ca1 area 3 days after ca in control rats, which was suppressed with gbc treatment. |
2020-05-11 |
2023-08-13 |
rat |
| Bo Ruan, Rui Wang, Yuan-Jian Yang, Dong-Fan Wang, Jia-Wen Wang, Chang-Cheng Zhang, Ding Yuan, Zhi-Yong Zhou, Ting Wan. [Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 2. 2019-08-05. PMID:30989956. |
western blot was used to detect the protein levels of nlrp3,asc,caspase-1 and the changes of glu a1,glu a2,camk\xe2\x85\xa1,creb and phosphorylation of camk\xe2\x85\xa1,creb in each group.the results showed that spj could improve the decline of cognitive function in aging rats,reduce the damage of ltp in the hippocampal ca1 region of aged rats,and decrease the expression of nlrp3,asc,caspase-1 in aging rats. |
2019-08-05 |
2023-08-13 |
rat |
| Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping M. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicology and applied pharmacology. vol 286. issue 1. 2015-08-05. PMID:25791922. |
immunohistochemistry showed that curcumin inhibited p-ire1\xce\xb1, p-perk and nlrp3 expression in hippocampus ca1 region. |
2015-08-05 |
2023-08-13 |
rat |