| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuai Feng, Juanji Li, Tingting Liu, Shiqi Huang, Xiangliang Chen, Shen Liu, Junshan Zhou, Hongdong Zhao, Ye Hon. Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819062. |
finally, we found that the overexpression of low-density lipoprotein receptor inhibited nlrp3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin, an nlrp3 agonist, restored the neurotoxic astrocyte phenotype. |
2024-06-06 |
2024-06-08 |
mouse |
| Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Chen. CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3. Neuroreport. 2024-03-25. PMID:38526919. |
cxcl13/cxcr5 promote chronic postsurgical pain and astrocyte activation in rats by targeting nlrp3. |
2024-03-25 |
2024-03-28 |
rat |
| Jinsong Xue, Keju Tao, Weijia Wang, Xiaofei Wan. What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson's Disease? International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338925. |
additionally, we describe the potential anti-inflammatory therapies, including nod-like receptor pyrin domain containing protein 3 (nlrp3) inflammasome inhibition, nuclear factor κb (nf-κb) inhibition, microglia inhibition, astrocyte inhibition, nicotinamide adenine dinucleotide phosphate (nadph) oxidase inhibition, the peroxisome proliferator-activated receptor γ (pparγ) agonist, targeting the mitogen-activated protein kinase (mapk) pathway, targeting the adenosine monophosphate-activated protein kinase (ampk)-dependent pathway, targeting α-synuclein, targeting mirna, acupuncture, and exercise. |
2024-02-10 |
2024-02-12 |
Not clear |
| Bing Wang, Li-Na Wang, Bin Wu, Ran Guo, Li Zhang, Jiang-Tao Zhang, Zhi-Hong Wang, Feng Wu, Yu Feng, Hong Liu, Xiao-Hong Jin, Xiu-Hua Miao, Tong Li. Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord. Anesthesiology. 2023-12-11. PMID:38079113. |
astrocyte perk and ire1 signaling contributes to morphine tolerance and hyperalgesia through upregulation of lipocalin-2 and nlrp3 inflammasome in the rodent spinal cord. |
2023-12-11 |
2023-12-17 |
Not clear |
| Juanji Li, Pengfei Xu, Ye Hong, Yi Xie, Mengna Peng, Rui Sun, Hongquan Guo, Xiaohao Zhang, Wusheng Zhu, Junjun Wang, Xinfeng Li. Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury. Journal of neuroinflammation. vol 20. issue 1. 2023-06-23. PMID:37353794. |
lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via nlrp3 inflammasome activation in cerebral ischemia/reperfusion injury. |
2023-06-23 |
2023-08-14 |
Not clear |
| Yu Fang, Hong Guo, Qiannan Wang, Congcong Liu, Shuyi Ge, Bohua Ya. The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression. Frontiers in pharmacology. vol 13. 2022-12-12. PMID:36506556. |
the role and mechanism of nlrp3 inflammasome-mediated astrocyte activation in dehydrocorydaline against cums-induced depression. |
2022-12-12 |
2023-08-14 |
Not clear |
| Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu, Xiaoyong Re. NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia. BMC neuroscience. vol 23. issue 1. 2022-11-27. PMID:36437451. |
nlrp3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia. |
2022-11-27 |
2023-08-14 |
Not clear |
| Shanshan Li, Yinquan Fang, Yihe Zhang, Mengmeng Song, Xilin Zhang, Xiao Ding, Hang Yao, Miaomiao Chen, Yiming Sun, Jianhua Ding, Qin Wang, Ming Lu, Guangyu Wu, Gang H. Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice. Cell reports. vol 41. issue 4. 2022-10-26. PMID:36288697. |
more interestingly, global or microglia-specific knockout of nod-like receptor protein 3 (nlrp3) markedly mitigates a1-like astrocyte induction, whereas astrocyte-specific nlrp3 depletion is ineffective. |
2022-10-26 |
2023-08-14 |
mouse |
| Sahithi Attaluri, Meenakshi Arora, Leelavathi N Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R Ghahfarouki, M N V Ravikumar, Ashok K Shett. Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and disease. vol 13. issue 2. 2022-04-04. PMID:35371600. |
lessened neuroinflammation was noticeable from reductions in astrocyte hypertrophy, nf-kb, activated microglia with nlrp3 inflammasomes, and multiple proinflammatory cytokines. |
2022-04-04 |
2023-08-13 |
rat |
| Ting Xiao, Heyu Ji, Xuejuan Shangguan, Shuangquan Qu, Yulong Cui, Junmei X. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochemical and biophysical research communications. vol 602. 2022-03-05. PMID:35247698. |
nlrp3 inflammasome of microglia promotes a1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. |
2022-03-05 |
2023-08-13 |
mouse |
| Ayan Mondal, Punnag Saha, Dipro Bose, Somdatta Chatterjee, Ratanesh K Seth, Shuo Xiao, Dwayne E Porter, Bryan W Brooks, Geoff I Scott, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterje. Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. Toxicology. vol 461. 2021-10-13. PMID:34416350. |
an increased circulatory s100b release, a hallmark of astrocyte activation in mc-lr exposed nafld mice also confirmed bbb integrity loss, but the astrocyte activation observed in vivo was nlrp3 independent suggesting an important role of a secondary s100b mediated crosstalk. |
2021-10-13 |
2023-08-13 |
mouse |
| Zhujin Song, Zhijuan Bian, Zhengrong Zhang, Xuncui Wang, Aisong Zhu, Guoqi Zh. Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice. Toxicology and applied pharmacology. vol 429. 2021-09-14. PMID:34474083. |
the blockage of n-methyl-d-aspartate receptors (nmdar) by memantine reduced lps-induced depression-like behaviors, nlrp3 inflammasome and astrocyte activation, and calpain-1 expression. |
2021-09-14 |
2023-08-13 |
mouse |
| Leelavathi N Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K Shett. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox biology. vol 43. 2021-07-05. PMID:33933884. |
behavioral tests revealed cognitive and mood dysfunction in gwi rats receiving vehicle, which were associated with elevated oxidative stress, reduced nrf2, catalase and mitochondrial complex proteins, astrocyte hypertrophy, activated microglia with nlrp3 inflammasomes, elevated proinflammatory cytokines, waned neurogenesis, and synapse loss in the hippocampus. |
2021-07-05 |
2023-08-13 |
rat |
| Lucineia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lobo Metzker, Erica Bernardo Biehl, Thaynan Vieira, Fabiana Durante de Medeiros, Naiana da Rosa, Jaqueline Generoso, Lutiana Simoes, Hémelin Resende Farias, Isabela da Silva Lemos, Vijayasree Giridharan, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Rafael Mariano Bitencourt, Emilio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32870491. |
nlrp3 receptor levels increased in the prefrontal cortex and hippocampus at 24 h after sepsis, associated with microglial, but not astrocyte, activation. |
2021-07-01 |
2023-08-13 |
rat |
| Baohua Hou, Yahui Zhang, Peiyu Liang, Yuan He, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua H. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32415059. |
however, it remains unknown whether the nlrp3 inflammasome contributes to cognitive deficits and astrocyte phenotype alteration in eae. |
2021-04-07 |
2023-08-13 |
mouse |
| Baohua Hou, Yahui Zhang, Peiyu Liang, Yuan He, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua H. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32415059. |
altogether, our present data suggest that the nlrp3 inflammasome plays an important role in cognitive deficits in eae, possibly via the alteration of astrocyte phenotypes. |
2021-04-07 |
2023-08-13 |
mouse |
| Yang Peng, Hongyan Li, Dandan Che. Silencing astrocyte elevated gene-1 attenuates lipopolysaccharide-induced inflammation and mucosal barrier injury in NCM460 cells by suppressing the activation of NLRP3 inflammasome. Cell biology international. vol 43. issue 1. 2019-01-25. PMID:30489008. |
silencing astrocyte elevated gene-1 attenuates lipopolysaccharide-induced inflammation and mucosal barrier injury in ncm460 cells by suppressing the activation of nlrp3 inflammasome. |
2019-01-25 |
2023-08-13 |
Not clear |