| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yifan Li, Bingyu Zhang, Jie Xu, Xiao Jiang, Liang Jing, Yanghua Tian, Kai Wang, Juanjuan Zhan. Inhibiting the JNK Signaling Pathway Attenuates Hypersensitivity and Anxiety-Like Behavior in a Rat Model of Non-specific Chronic Low Back Pain. Journal of molecular neuroscience : MN. vol 74. issue 3. 2024-07-24. PMID:39046556. |
these results showed that hypersensitivity and anxiety-like behavior induced by ngf in lbp rats could be attenuated by the jnk inhibitor, together with downregulation of spinal astrocyte activation, neuron activation, and inflammatory cytokines. |
2024-07-24 |
2024-07-26 |
rat |
| María García-Bonilla, Betsaida Ojeda-Pérez, Kirill Shumilov, Luis-Manuel Rodríguez-Pérez, Dolores Domínguez-Pinos, Javier Vitorica, Sebastián Jiménez, Reposo Ramírez-Lorca, Miriam Echevarría, Casimiro Cárdenas-García, Teresa Iglesias, Antonia Gutiérrez, James P McAllister, David D Limbrick, Patricia Páez-González, Antonio J Jiméne. Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982724. |
in the cerebral tissue, mrna overexpression of nerve growth factor (ngf), vascular endothelial growth factor (vegf), hypoxia-inducible factor-1 (hif1α), and transforming growth factor beta 1 (tgfβ1) could be related to the regulation of the astrocyte reaction and aqp4 expression. |
2023-03-29 |
2023-08-14 |
mouse |
| Chunshuai Wu, Guanhua Xu, Guofeng Bao, Hong Gao, Jiajia Chen, Jinlong Zhang, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Yang Liu, Jiayi Huang, Yue Sun, Jiawei Fu, Yiqiu Li, Zhiming Cu. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotropin. The Journal of biological chemistry. 2022-09-02. PMID:36055408. |
we also show using flow cytometry and astrocyte/neuronal co-culture assays that triad1 overexpression promoted ptn protein levels, neurotrophic growth factor (ngf) expression, brain-derived neurotrophic factor (bdnf) expression, astrocyte and neuronal viability, and neurite outgrowth, but suppressed astrocyte apoptosis, while shrna-mediated knockdown of triad1 and ptn had the opposite effects. |
2022-09-02 |
2023-08-14 |
rat |
| Zhenzhen Xu, Jianxiang Jiang, Shengyuan Xu, Zunchun Xie, Pei He, Shishi Jiang, Renshi X. Nerve Growth Factor is a Potential Treated Target in Tg(SOD1*G93A)1Gur Mice. Cellular and molecular neurobiology. 2021-12-05. PMID:33236288. |
the astrocyte, neuron, and oligodendrocyte produced the ngf and the neural precursor cells (npcs) produced the ngf. |
2021-12-05 |
2023-08-13 |
mouse |
| Shinichi Ishiguro, Tetsuro Shinada, Zhou Wu, Mayumi Karimazawa, Michimasa Uchidate, Eiji Nishimura, Yoko Yasuno, Makiko Ebata, Piyamas Sillapakong, Hiromi Ishiguro, Nobuyoshi Ebata, Junjun Ni, Muzhou Jiang, Masanobu Goryo, Keishi Otsu, Hidemitsu Harada, Koichi Suzuk. A novel cyclic peptide (Naturido) modulates glia-neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice. PloS one. vol 16. issue 1. 2021-05-17. PMID:33503058. |
we found that naturido significantly enhanced astrocyte proliferation and activated the single copy gene encoding the neuropeptide vgf and the neuron-derived ngf gene. |
2021-05-17 |
2023-08-13 |
mouse |
| Carmen La Porta, Anke Tappe-Theodo. Differential impact of psychological and psychophysical stress on low back pain in mice. Pain. vol 161. issue 7. 2021-05-14. PMID:32132393. |
interestingly, the exposure to chronic unpredictable stress slightly worsened pain behavior, whereas vcrs primed and highly aggravated pain in this lbp model, by causing per se the intramuscular upregulation of endogenous ngf and increased spinal astrocyte expression. |
2021-05-14 |
2023-08-13 |
mouse |
| Xiaogang Chen, Lin Zhang, Fu Hua, Yu Zhuang, Huan Liu, Shouguo Wan. EphA4 Obstructs Spinal Cord Neuron Regeneration by Promoting Excessive Activation of Astrocytes. Cellular and molecular neurobiology. 2021-02-17. PMID:33595805. |
we found that the levels of neurotrophic factors including nerve growth factor (ngf) and basic fibroblast growth factor (bfgf) increased significantly after sci (ngf peaked at 3 days and bfgf peaked at 7 days); the expression of laminin and fibronectin increased gradually after sci; the expression of inflammatory factors [interleukin (il)-1β and il-6] increased significantly from 4 h to 7 days after sci; and the levels of glial fibrillary acidic protein (gfap), a marker of astrocyte activation, and chondroitin sulphate proteoglycan (cspg), the main component of glial scars, both peaked at 7 days after sci. |
2021-02-17 |
2023-08-13 |
Not clear |
| Matthias Spranger, Dan Lindholm, Christine Bandtlow, Rolf Heumann, Hannes Gnahn, Martina Näher-Noé, Hans Thoene. Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin-1 and Various Growth Factors in Astrocyte Cultures and in vivo. The European journal of neuroscience. vol 2. issue 1. 2019-11-20. PMID:12106104. |
regulation of nerve growth factor (ngf) synthesis in the rat central nervous system: comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. |
2019-11-20 |
2023-08-12 |
rat |
| John S. Rudge, Ralph F. Alderson, Elizabeth Pasnikowski, Joyce McClain, Nancy Y. Ip, Ronald M. Lindsa. Expression of Ciliary Neurotrophic Factor and the Neurotrophins-Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin 3-in Cultured Rat Hippocampal Astrocytes. The European journal of neuroscience. vol 4. issue 6. 2019-11-20. PMID:12106332. |
in order to examine which factors may be responsible for these activities, we have examined the expression of the genes for four known neurotrophic factors-ciliary neurotrophic factor (cntf), nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt3)-in purified astrocyte cultures derived from neonatal rat hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Julien Genty, Milène Tetsi Nomigni, Fernand Anton, Ulrike Hanesc. The combination of postnatal maternal separation and social stress in young adulthood does not lead to enhanced inflammatory pain sensitivity and depression-related behavior in rats. PloS one. vol 13. issue 8. 2019-02-08. PMID:30142161. |
despite the finding that stress conditions differentially affected different players of glutamatergic transmission, astrocyte activity and ngf expression, our biochemical results could not readily be related to the behavioral observations, precluding a congruent conclusion. |
2019-02-08 |
2023-08-13 |
rat |
| Changhui Qian, Dandan Tan, Xianghai Wang, Lixia Li, Jinkun Wen, Mengjie Pan, Yuanyuan Li, Wutian Wu, Jiasong Gu. Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration. Neural plasticity. vol 2018. 2018-11-26. PMID:29849572. |
additionally, we found that the expression of neurotrophins, including brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), and neurotrophin-3 (nt-3), also accompanied with astrocyte activation. |
2018-11-26 |
2023-08-13 |
human |
| Cheng Cao, Junyuan Xiao, Mengqiu Liu, Zishuo Ge, Renjie Huang, Mingzhu Qi, Hongliang Zhu, Yue Zhu, Jin-Ao Dua. Active components, derived from Kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor NGF and BDNF on mouse astrocyte primary cultures via cAMP-dependent signaling pathway. Journal of ethnopharmacology. vol 224. 2018-11-13. PMID:29890314. |
active components, derived from kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor ngf and bdnf on mouse astrocyte primary cultures via camp-dependent signaling pathway. |
2018-11-13 |
2023-08-13 |
mouse |
| Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısma. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical cellular pathology (Amsterdam). vol 2017. 2018-08-10. PMID:28458992. |
levels of dopamine, secreted from the substantia nigra, nerve growth factor (ngf) developed from the hippocampal neurons, and gfap, secreted from astrocyte cells, were detected to be significantly lower in the toluene-administration group than in the control group ( |
2018-08-10 |
2023-08-13 |
rabbit |
| Hyo Geun Kim, Soonmin Lim, Jongki Hong, Ae-Jung Kim, Myung Sook O. Effects of Myoga on Memory and Synaptic Plasticity by Regulating Nerve Growth Factor-Mediated Signaling. Phytotherapy research : PTR. vol 30. issue 2. 2016-07-01. PMID:26563629. |
in a rat primary hippocampal astrocyte culture system, treatment with myoga extract for 24 h significantly stimulated the production of ngf. |
2016-07-01 |
2023-08-13 |
mouse |
| You Sun Kim, Dong Hyun Jo, Hanjae Lee, Jin Hyoung Kim, Kyu-Won Kim, Jeong Hun Ki. Nerve growth factor-mediated vascular endothelial growth factor expression of astrocyte in retinal vascular development. Biochemical and biophysical research communications. vol 431. issue 4. 2013-05-09. PMID:23337506. |
in cultured primary astrocyte, recombinant nerve growth factor (ngf) was used to activate trka. |
2013-05-09 |
2023-08-12 |
mouse |
| T Yabe, H Yamad. Induction mechanism of nerve growth factor synthesis by Kami-untan-to; Role of cyclic AMP and c-fos mRNA accumulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 4. issue 3. 2012-12-03. PMID:23195475. |
addition of kut in astroglial cell cultures also induced expression of c-fos mrna, and was followed by induction of ngf mrna. |
2012-12-03 |
2023-08-12 |
Not clear |
| Andrea B Cragnolini, Marta Volosin, Yangyang Huang, Wilma J Friedma. Nerve growth factor induces cell cycle arrest of astrocytes. Developmental neurobiology. vol 72. issue 6. 2012-09-28. PMID:21954122. |
in this study, the authors investigated the role of nerve growth factor (ngf) in regulating astrocyte proliferation and in influencing specific aspects of the cell cycle. |
2012-09-28 |
2023-08-12 |
Not clear |
| Tin-Tin Win-Shwe, Naoki Kunugita, Yasuhiro Yoshida, Daisuke Nakajima, Shinji Tsukahara, Hidekazu Fujimak. Differential mRNA expression of neuroimmune markers in the hippocampus of infant mice following toluene exposure during brain developmental period. Journal of applied toxicology : JAT. vol 32. issue 2. 2012-05-23. PMID:21381054. |
in contrast, ngf and brain-derived neurotrophic factor (bdnf) and proinflammatory cytokines tnf-α, ccl3, nf-κb, toll-like receptor (tlr)-4, astrocyte marker glial fibrillary acidic protein (gfap), and microglia marker ionized calcium binding adapter molecule (iba)-1 mrnas were increased significantly in mice exposed to 5 ppm toluene on pnd 8-12. |
2012-05-23 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Shun-Wei Zhu, Rui-Sheng Duan, Abdul H Mohammed, Bengt Winblad, Jie Zh. Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18342945. |
clinical signs, behavioural changes, pathological changes and astrocyte proliferation were tested; and the levels of brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) were measured after ka treatment. |
2008-08-25 |
2023-08-12 |
mouse |
| Bing Xue, Jian Jiao, Lei Zhang, Kai-Rong Li, Yun-Tao Gong, Jun-Xia Xie, Xiao-Min Wan. Triptolide upregulates NGF synthesis in rat astrocyte cultures. Neurochemical research. vol 32. issue 7. 2007-09-17. PMID:17401680. |
triptolide upregulates ngf synthesis in rat astrocyte cultures. |
2007-09-17 |
2023-08-12 |
rat |