All Relations between nac and medial prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yu. Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948992. we determined dopamine transporter (dat) availability in the medial prefrontal cortex (mpfc), striatum, and nucleus accumbens (nac) after drug treatment. 2023-11-10 2023-11-20 mouse
Joseph S Lonstein, Erika M Vitale, Doris Olekanma, Andrew McLocklin, Nathan Pence, Remco Bredewold, Alexa H Veenema, Alexander W Johnson, S Alexandra Bur. Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early-life disadvantage. Developmental psychobiology. vol 65. issue 7. 2023-10-20. PMID:37860907. d1 and d2 receptor mrna in the medial prefrontal cortex and nucleus accumbens (nac) were each affected by the early-life treatments and differently between the sexes. 2023-10-20 2023-11-08 rat
Daniel J Lodge, Hannah B Elam, Angela M Boley, Jennifer J Donega. Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons. Nature communications. vol 14. issue 1. 2023-10-20. PMID:37863893. these results suggest vhipp interneurons differentially regulate that vhipp neurons that project to the medial prefrontal cortex (mpfc) and nac. 2023-10-20 2023-11-08 Not clear
Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Che. Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway. Neurobiology of stress. vol 26. 2023-09-04. PMID:37664874. concurrent with behavioral amelioration, the csds dbs-on group exhibited enhanced fc in the dopaminergic pathway with increased expression of bdnf- and neun-positive cells increased dopamine d1 receptor, dopamine d2 receptors, and th in the medial prefrontal cortex, nac, ventral hippocampus, ventral tegmental area, and amygdala. 2023-09-04 2023-09-07 mouse
Giuseppe Tringali, Gianluca Lavanco, Valentina Castelli, Giuseppe Pizzolanti, Martin Kuchar, Diego Curr\\xc3\\xb2, Carla Cannizzaro, Anna Brancat. Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking \\xc2\\xa0adolescent rats. Focus on calcitonin gene-related peptide's brain levels. Phytotherapy research : PTR. 2023-08-01. PMID:37525534. adolescent male rats underwent the intermittent 20% alcohol two-bottle choice paradigm; at the binge day (bd) and the 24\xe2\x80\x89h withdrawal day (wd), we assessed cgrp expression in medial prefrontal cortex (mpfc), nucleus accumbens (nac), amygdala, hypothalamus and brainstem; in addition, we evaluated\xc2\xa0sucrose preference, social motivation and drive, nociceptive response, and serum corticosterone levels. 2023-08-01 2023-08-14 rat
Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knacksted. Brain Monoamine Dysfunction in Response to Predator Scent Stress Accompanies Stress-Susceptibility in Female Rats. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509091. using a predator scent stress (pss) rodent model of ptsd, we sought to determine if stress-susceptible female rats show altered monoamine concentrations in brain regions associated with ptsd: the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and dorsal (dhipp) and ventral (vhipp) hippocampus. 2023-07-29 2023-08-14 rat
Julie-Anne Balouek, Christabel A Mclain, Adelaide R Minerva, Rebekah L Rashford, Shannon N Bennett, Forrest D Rogers, Catherine Jensen Pe\\xc3\\xb1. Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-10. PMID:37429717. we found that in both male and female mice, els-activated neurons within the nucleus accumbens (nac), and to a lesser-extent the medial prefrontal cortex, were preferentially reactivated by adult stress. 2023-07-10 2023-08-14 mouse
Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-Xiang Liu, Cheng Lon. Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice. Stress (Amsterdam, Netherlands). vol 26. issue 1. 2023-07-03. PMID:37395260. here we report that cyld deficiency leads to an unexpected reaction to ars in mice, and is accompanied by significant neuronal activation of brain regions including the medial prefrontal cortex (mpfc), dorsal striatum (ds), nucleus accumbens (nac), and basal lateral amygdala (bla), but not ventral hippocampus (vhpc). 2023-07-03 2023-08-14 mouse
Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. we found that ketamine rescues stress-induced reduction in excitatory strength at medial prefrontal cortex and ventral hippocampus inputs to nac d1-msns. 2023-06-19 2023-08-14 mouse
Jennifer M Wenzel, Natalie E Zlebnik, Mary H Patton, John R Smethells, Victoria M Ayvazian, Hannah M Dantrassy, Lan-Yuan Zhang, Brian N Mathur, Joseph F Chee. Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-19. PMID:37208501. the prelimbic region of the medial prefrontal cortex (mpfc) was injected with a viral vector expressing inhibitory designer receptors exclusively activated by designer drugs (gi-dreadd), and then mpfc projections to the nucleus accumbens core (nac) were selectively suppressed by intra-nac administration of the gi-dreadd actuator clozapine-n-oxide (cno). 2023-05-19 2023-08-14 human
Wei-Zhu Liu, Chun-Yan Wang, Yu Wang, Mei-Ting Cai, Wei-Xiang Zhong, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang, Bing-Xing Pa. Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress. Cell & bioscience. vol 13. issue 1. 2023-05-19. PMID:37208769. the medial prefrontal cortex (mpfc) is a hub for controlling stress responses through communicating with multiple limbic structures, including the basolateral amygdala (bla) and nucleus accumbens (nac). 2023-05-19 2023-08-14 Not clear
F Javier Rubio, Daniel E Olivares, Christopher Dunn, Shiliang Zhang, Elias M Hilaire, Akeem Henry, Carlos Mejias-Aponte, Carlos J Nogueras-Ortiz, Pooja V Selvam, Fabio C Cruz, Rajtarun Madangopal, Marisela Morales, Bruce T Hop. Flow cytometry of synaptoneurosomes (FCS) reveals increased ribosomal S6 and calcineurin proteins in activated medial prefrontal cortex to nucleus accumbens synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-09. PMID:37160369. after injecting yfp-expressing aav into medial prefrontal cortex (mpfc) to label terminals in nucleus accumbens (nac) of rats, we injected 20 mg/kg of cocaine in a novel context (cocaine+novelty) to activate synapses, and prepared nac synaptoneurosomes 0-60 min following injections. 2023-05-09 2023-08-14 rat
Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. the present study demonstrated for the first time that acute as well as subchronic (4\xe2\x80\xafdays) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3\xe2\x80\xafmg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the \xce\xb2-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). 2023-03-04 2023-08-14 rat
Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Koz\\xc5\\x82owska, Bai-Chung Shyu, Andrew Chih Wei Huan. Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats. Frontiers in pharmacology. vol 14. 2023-02-10. PMID:36762112. to re-examine the paradoxical effect hypothesis of abused drugs, the present study concerned whether different doses of morphine disparately affect neuronal activity and associations among the subareas of the medial prefrontal cortex (mpfc: cingulate cortex 1-cg1, prelimbic cortex-prl, infralimbic cortex-il), the subregions of the nucleus accumbens (nac; both core and shell), and the basolateral amygdala (bla) following conditioned taste aversion (cta) and conditioned place preference (cpp). 2023-02-10 2023-08-14 rat
Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Ga. Excitatory projections from the prefrontal cortex to nucleus accumbens core D1-MSNs and kappa opioid receptor modulate itch-related scratching behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-18. PMID:36653189. excitatory afferents from the medial prefrontal cortex (mpfc), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor d1- and d2-expressing medium spiny neurons (drd1- and drd2-msns) in the nac. 2023-01-18 2023-08-14 mouse
Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research. 2022-12-05. PMID:36470419. moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). 2022-12-05 2023-08-14 Not clear
Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), \xce\xb1-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). 2022-11-07 2023-08-14 rat
Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience. vol 21. issue 5. 2022-09-22. PMID:36137960. in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). 2022-09-22 2023-08-14 Not clear
Myung Ji Kwak, Wha Young Kim, Seung-Hyun Jung, Yeun-Jun Chung, Jeong-Hoon Ki. Differential transcriptome profile underlying risky choice in a rat gambling task. Journal of behavioral addictions. 2022-09-12. PMID:36094860. in the present study, we examined using next-generation sequencing (ngs) technique whether there are differences in gene expression profiles in the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac) when rats make different choices toward risk in rgt. 2022-09-12 2023-08-14 rat
Carlos Morgan, Patricio S\\xc3\\xa1ez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel R\\xc3\\xados, Paulina Ram\\xc3\\xadrez, H\\xc3\\xa9ctor Burgos, Alejandro Hern\\xc3\\xa1nde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077493. a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. 2022-09-09 2023-08-14 mouse