| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peace N Dike, Krishnakant G Soni, Diana S Chang, Geoffrey A Preidi. Bile acids differentially regulate longitudinal smooth muscle contractility in everted mouse ileum. FASEB bioAdvances. vol 6. issue 7. 2024-07-08. PMID:38974116. |
the dose-dependent increase in contractility resulting from the application of ursodeoxycholic acid was recapitulated by int-777, an agonist of the takeda g protein-coupled receptor 5 (tgr5), and by cevimeline, a muscarinic acetylcholine receptor agonist. |
2024-07-08 |
2024-07-11 |
mouse |
| Arwa M Farag, Craig Holliday, Joseph Cimmino, Tamar Roomian, Athena Papa. Comparing the effectiveness and adverse effects of pilocarpine and cevimeline in patients with hyposalivation. Oral diseases. vol 25. issue 8. 2019-12-31. PMID:31520497. |
pilocarpine (pilo) and cevimeline (cev) are muscarinic acetylcholine receptor agonists that stimulate salivary gland function. |
2019-12-31 |
2023-08-13 |
Not clear |
| Yoshihiro Mitoh, Hirotaka Ueda, Hiroyuki Ichikawa, Masako Fujita, Motoi Kobashi, Ryuji Matsu. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Autonomic neuroscience : basic & clinical. vol 206. 2017-12-06. PMID:28600120. |
cevimeline, a muscarinic acetylcholine receptor (machr) agonist, is a sialogogue that possibly stimulates ssn neurons in addition to the salivary glands themselves because it can cross the blood-brain barrier (bbb). |
2017-12-06 |
2023-08-13 |
rat |
| Xin Cong, Yan Zhang, Jing Li, Mei Mei, Chong Ding, Ruo-Lan Xiang, Li-Wei Zhang, Yun Wang, Li-Ling Wu, Guang-Yan Y. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. Journal of cell science. vol 128. issue 12. 2016-03-22. PMID:25948584. |
here, we found that machr activation by carbachol and cevimeline reduced the transepithelial electrical resistance (ter) and increased the permeability of paracellular tracers in rat salivary epithelial smg-c6 cells. |
2016-03-22 |
2023-08-13 |
rat |
| Yosuke Suzuki, Hiroki Itoh, Kohei Amada, Ryota Yamamura, Yuhki Sato, Masaharu Takeyam. Significant increase in salivary substance p level after a single oral dose of cevimeline in humans. International journal of peptides. vol 2013. 2013-04-17. PMID:23589717. |
cevimeline is a novel muscarinic acetylcholine receptor agonist currently being developed as a therapeutic agent for xerostomia. |
2013-04-17 |
2023-08-12 |
human |
| Hirotaka Ueda, Yoshihiro Mitoh, Masako Fujita, Motoi Kobashi, Takashi Yamashiro, Tomosada Sugimoto, Hiroyuki Ichikawa, Ryuji Matsu. Muscarinic receptor immunoreactivity in the superior salivatory nucleus neurons innervating the salivary glands of the rat. Neuroscience letters. vol 499. issue 1. 2012-05-08. PMID:21624431. |
cevimeline, a muscarinic acetylcholine receptor agonist, stimulates the salivary glands and is presently used as sialogogue in the treatment of dry mouth. |
2012-05-08 |
2023-08-12 |
rat |
| Di Wang, Fusako Iwata, Masahiro Muraguchi, Keiko Ooga, Yasukazu Ohmoto, Masaaki Takai, Toyoki Mori, Yasuko Ishikaw. Correlation between salivary secretion and salivary AQP5 levels in health and disease. The journal of medical investigation : JMI. vol 56 Suppl. 2010-06-21. PMID:20224222. |
cevimeline, a muscarinic acetylcholine receptor (machr) agonist, induces the release of aqp5. |
2010-06-21 |
2023-08-12 |
human |
| Yasuko Ishikawa, Zhenfang Yuan, Noriko Inoue, Mariusz T Skowronski, Yoshiko Nakae, Masayuki Shono, Gota Cho, Masato Yasui, Peter Agre, Søren Nielse. Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. American journal of physiology. Cell physiology. vol 289. issue 5. 2005-11-07. PMID:16107506. |
confocal microscopy revealed aqp5 localization in intracellular vesicles of interlobular duct cells in rat parotid glands and aqp5 trafficking to the apm 10 min after injection of the machr agonist cevimeline. |
2005-11-07 |
2023-08-12 |
rat |
| Masasfumi Ono, Etsuko Takamura, Kazumi Shinozaki, Tomoko Tsumura, Takashi Hamano, Yukiko Yagi, Kazuo Tsubot. Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study. American journal of ophthalmology. vol 138. issue 1. 2004-08-31. PMID:15234277. |
recently, a muscarinic acetylcholine receptor agonist, cevimeline, has been approved for use against symptoms of dry mouth in patients with ss. |
2004-08-31 |
2023-08-12 |
Not clear |
| Takuo Washio, Kazuhiro Kohsaka, Hirohiko Arisawa, Hiroaki Masunaga, Shin-ichiro Nagatsuka, Yoshiaki Sato. Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011. Arzneimittel-Forschung. vol 53. issue 2. 2003-04-16. PMID:12642962. |
the pharmacokinetics and metabolism of sni-2011 ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine]monohydrochloride hemihydrate, cevimeline, cas 153504-70-2), a novel muscarinic acetylcholine receptor agonist developed for the treatment of sjögen's syndrome, were investigated in six healthy volunteers after a single oral administration of 14c-sni-2011. |
2003-04-16 |
2023-08-12 |
human |
| Takuo Washio, Kazuhiro Kohsaka, Hirohiko Arisawa, Hiroaki Masunag. Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittel-Forschung. vol 53. issue 1. 2003-03-28. PMID:12608011. |
in this study, the pharmacokinetics of sni-2011 ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine]monohydrochloride hemihydrate, cevimeline, cas 153504-70-2), a novel muscarinic acetylcholine receptor agonist developed for the treatment of sjögren's syndrome, in rats and dogs were determined following intravenous or oral administration using liquid chromatography/mass spectrometry (lc/ms). |
2003-03-28 |
2023-08-12 |
rat |