| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vasiliki Karalis, Delaney Wood, Nicole A Teaney, Mustafa Sahi. The role of TSC1 and TSC2 proteins in neuronal axons. Molecular psychiatry. 2024-01-11. PMID:38212374. |
this complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mtor) kinase, and mutations in either tsc1 or tsc2 cause a neurodevelopmental disorder called tuberous sclerosis complex (tsc). |
2024-01-11 |
2024-01-14 |
Not clear |
| Paolo Curatolo, Mirte Scheper, Leonardo Emberti Gialloreti, Nicola Specchio, Eleonora Aronic. Is tuberous sclerosis complex-associated autism a preventable and treatable disorder? World journal of pediatrics : WJP. 2023-10-25. PMID:37878130. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by inactivating mutations in the tsc1 and tsc2 genes, causing overactivation of the mechanistic (previously referred to as mammalian) target of rapamycin (mtor) signaling pathway in fetal life. |
2023-10-25 |
2023-11-08 |
Not clear |
| Gurneel K Dhanesar, Harish Rengarajan, Baidarbhi Chakrabort. Malignant Perivascular Epithelioid Cell Tumor of the Uterus. Cureus. vol 15. issue 7. 2023-08-14. PMID:37575749. |
they belong to the family of mesenchymal tumors and include angiomyolipomas, clear cell sugar tumors of the lung, and pecomas not otherwise specified (nos). tuberous sclerosis complex 1 (tsc1) and tuberous sclerosis complex 2 (tsc2) gene mutation is associated with pecoma, which causes hyperactivation of the mammalian target of rapamycin (mtor) signaling pathway. |
2023-08-14 |
2023-08-16 |
Not clear |
| Marjan Taherian, Paria Bayati, Mohammad-Ali Assarehzadegan, Mansoureh Soleimani, Hadi Poormoghim, Nazanin Mojtabav. Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis. Iranian journal of allergy, asthma, and immunology. vol 22. issue 2. 2023-07-27. PMID:37496412. |
gene expression analyses indicated a significant elevation of regulatory associated protein of mtor (raptor), ras homolog enriched in brain (rheb), s6 kinase 1, and eukaryotic translation initiation factor 4e-binding protein 1 (4ebp1), as well as a significant reduction of vegfa, tuberous sclerosis complex (tsc2), and lrp1; no changes were observed in the tsc1 mrna level. |
2023-07-27 |
2023-08-14 |
mouse |
| Elisabetta Chiaradia, Ingrid Miller, Giovanni Renzone, Alessia Tognoloni, Alice Polchi, Federico De Marco, Brunella Tancini, Andrea Scaloni, Alessandro Magin. Proteomic analysis of murine Tsc1-deficient neural stem progenitor cells. Journal of proteomics. 2023-05-19. PMID:37207814. |
significance: tuberous sclerosis complex (tsc) is a multisystemic disorder caused by inactivating mutations of tsc1 or tsc2 genes, which induce overactivation of the mtor component. |
2023-05-19 |
2023-08-14 |
Not clear |
| Alfredo Cerisola, Lucía Cibils, María Eugenia Chaibún, Virginia Pedemonte, Melania Rosa. [Tuberous sclerosis complex: diagnosis and current treatment]. Medicina. vol 82 Suppl 3. 2022-09-02. PMID:36054862. |
tuberous sclerosis complex is an autosomal dominant genetic multisystemic disorder caused primarily by mutations in one of the two tumor suppressor genes tsc1 or tsc2, resulting in increased activation of the mtor pathway. |
2022-09-02 |
2023-08-14 |
Not clear |
| Paolo Curatolo, Nicola Specchio, Eleonora Aronic. Advances in the genetics and neuropathology of tuberous sclerosis complex: edging closer to targeted therapy. The Lancet. Neurology. vol 21. issue 9. 2022-08-13. PMID:35963265. |
tuberous sclerosis complex is a rare genetic disease associated with mutations in the tsc1 or tsc2 genes, which cause overactivation of the mtor complex. |
2022-08-13 |
2023-08-14 |
Not clear |
| Vasiliki Karalis, Franklin Caval-Holme, Helen S Bateu. Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex. Nature communications. vol 13. issue 1. 2022-08-09. PMID:35945201. |
tuberous sclerosis complex (tsc) is a neurodevelopmental disorder caused by mutations in the tsc1 or tsc2 genes, which encode proteins that negatively regulate mtor complex 1 (mtorc1) signaling. |
2022-08-09 |
2023-08-14 |
mouse |
| Guangxu Bai, Hao Wang, Na Cu. mTOR pathway mediates endoplasmic reticulum stress-induced CD4 Apoptosis : an international journal on programmed cell death. 2022-06-27. PMID:35759162. |
hence, in this study, a classical cecal ligation and puncture (clp) sepsis model was constructed by using the t cell-specific knockout mtor and tsc1 (tuberous sclerosis complex, the inhibitor of mtor signaling pathway) mice to explore the underlying signaling pathway and molecular mechanism of host immune imbalance caused by apoptosis in sepsis. |
2022-06-27 |
2023-08-14 |
mouse |
| Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, Aleksandra Badur. Frontiers in molecular neuroscience. vol 15. 2022-06-01. PMID:35645731. |
tuberous sclerosis complex 1 (tsc1) is a tumor suppressor that promotes the inhibition of mechanistic target of rapamycin (mtor) pathway, and mutations in |
2022-06-01 |
2023-08-13 |
Not clear |
| Elhusseiny Mohamed Mahmoud Abdelwahab, Judit Bovari-Biri, Gabor Smuk, Tunde Harko, Janos Fillinger, Judit Moldvay, Vera P Krymskaya, Judit E Pongrac. Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations. Frontiers in oncology. vol 11. 2021-11-12. PMID:34178631. |
mutation in a tuberous sclerosis gene (tsc1 or 2) leads to continuous activation of the mammalian target of rapamycin (mtor). |
2021-11-12 |
2023-08-13 |
Not clear |
| Davide Bassetti, Heiko J Luhmann, Sergei Kirischu. Presynaptic GABA Pflugers Archiv : European journal of physiology. vol 473. issue 8. 2021-10-18. PMID:34279736. |
presynaptic gaba the tsc1 and tsc2 tumor suppressor genes control the activity of mechanistic target of rapamycin (mtor) pathway. |
2021-10-18 |
2023-08-13 |
Not clear |
| Till S Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E Jansen, Fried J T Zwartkruis, Nicholas R Rensing, Michael Wong, Angelika Mühlebner, Erwin A van Vliet, Eleonora Aronica, James D Mill. Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33786950. |
tuberous sclerosis complex (tsc) is a congenital disorder characterized by cortical malformations and concomitant epilepsy caused by loss-of-function mutations in the mtor suppressors tsc1 or tsc2. |
2021-10-13 |
2023-08-13 |
Not clear |
| Hao Tang, Tong Fang, Meng Ji, Jun-Ping Wang, Le-Le Song, Qiu-Yan Zhang, Jin-Sheng W. UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1. Biochemical and biophysical research communications. vol 578. 2021-10-11. PMID:34520980. |
furthermore, we discovered that this ube2s-modulated carcinogenic mechanism was in the consequence of directly targeting tuberous sclerosis 1 (tsc1), which is the upstream inhibitor of mtor signaling for ubiquitous degradation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Anna Caliò, Matteo Brunelli, Diego Segala, Giuseppe Zamboni, Franco Bonetti, Maurizio Pea, Guido Martignon. Angiomyolipoma of the kidney: from simple hamartoma to complex tumour. Pathology. vol 53. issue 1. 2021-10-04. PMID:33131798. |
the activation of the mtor pathway due to genetic alterations of tuberous sclerosis complex in tsc1 or tsc2 genes in angiomyolipoma has also been reported as well as the subsequent therapeutic implications. |
2021-10-04 |
2023-08-13 |
Not clear |
| Tomas Petrasek, Iveta Vojtechova, Ondrej Klovrza, Klara Tuckova, Cestmir Vejmola, Jakub Rak, Anna Sulakova, Daniel Kaping, Nadine Bernhardt, Petrus J de Vries, Jakub Otahal, Robert Walterei. mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus. Journal of neurodevelopmental disorders. vol 13. issue 1. 2021-08-26. PMID:33863288. |
tuberous sclerosis complex (tsc), a multi-system genetic disorder often associated with autism spectrum disorder (asd), is caused by mutations of tsc1 or tsc2, which lead to constitutive overactivation of mammalian target of rapamycin (mtor). |
2021-08-26 |
2023-08-13 |
Not clear |
| Camilla Russo, Anna Nastro, Domenico Cicala, Maria De Liso, Eugenio Maria Covelli, Giuseppe Cinall. Neuroimaging in tuberous sclerosis complex. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 36. issue 10. 2021-06-21. PMID:32519125. |
tuberous sclerosis complex (tsc) is a rare autosomal dominant disorder affecting multiple systems, due to inactivating mutations of tsc1 or tsc2 mtor pathway genes. |
2021-06-21 |
2023-08-13 |
Not clear |
| Morris Nechama, Yaniv Makayes, Elad Resnick, Karen Meir, Oded Volovelsk. Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex-associated cystic kidney disease. JCI insight. vol 5. issue 13. 2021-06-09. PMID:32484794. |
using targeted deletion of tsc1 in nephron progenitor cells, we showed that cysts in tsc1-null embryonic kidneys originate from injured proximal tubular cells with high mtor complex 1 activity. |
2021-06-09 |
2023-08-13 |
mouse |
| Yanli Wang, Sijun Diao, Maoqing Hu, Lin Zhan. Methylation of Hypothalamic Tsc1-mTOR Signaling in Regulation of Obesity and Obesity Resistance. BioMed research international. vol 2020. 2021-05-27. PMID:33532487. |
both mrna and protein expression levels of tsc1 in dio group hypothalamus were lower; mtor and its downstream targets s6k1, 4ebp1, and s6 protein expression levels were higher than those of the dio-r group and the chow group. |
2021-05-27 |
2023-08-13 |
rat |
| Jiande Li, Shaobo Du, Yongpeng Shi, Jiangyuan Han, Zhanyu Niu, Li Wei, Pengfei Yang, Linchi Chen, Huanbing Tian, Lan Ga. Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. Experimental eye research. vol 203. 2021-04-23. PMID:33352197. |
rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse tsc1 and mtor genes. |
2021-04-23 |
2023-08-13 |
mouse |