| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoxiu Wang, Qian Zhang, Zhanyu Chen, Yongliang Huang, Weimin Wang, Xiaoxue Zhang, Jiale Jia, Qihao Gao, Haoyu Xu, Chong L. Transcriptome Analysis to Elucidate the Effects of Milk Replacer Feeding Level on Intestinal Function and Development of Early Lambs. Animals : an open access journal from MDPI. vol 13. issue 11. 2023-10-29. PMID:37889672. |
further, intensive mr feeding affected insulin sensitivity to reduce excessive glucose interception by intestinal tissues to ensure adequate absorbed glucose release into the portal circulation and promoted lipid and protein degradation in intestinal tissues to meet the energy demand of intestinal cells by regulating |
2023-10-29 |
2023-11-08 |
Not clear |
| Xing Wang, Dianpeng Zhao, Lichao Cheng, Jing Gao, Jian Li, Chao Gen. Mendelian randomization explores the causal relationships between obesity, diabetes, inflammation and nonalcoholic fatty liver disease. Medicine. vol 102. issue 38. 2023-09-25. PMID:37747017. |
in this study, based on the genome-wide association study (gwas) data, a two-sample mendelian randomization (mr) analysis was conducted to evaluate the causality between nafld and 6 clinical indicators, including body mass index (bmi), waist-to-hip ratio (whr), c-reactive protein (crp), fasting blood glucose (fg), fasting insulin (fi), and glycosylated hemoglobin (hba1c). |
2023-09-25 |
2023-10-07 |
Not clear |
| Chu-Mao Chen, Xiao-Qian Meng, Hong Zhu, Ting Liu, Yuan Liu, Lu-Jun Zhou, Guo-Dong Zhu, Xiao-Bei Chen, Xu-Guang Guo, Sheng-Zhong Dua. Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice. Journal of lipid research. 2023-09-21. PMID:37734559. |
after 8 weeks of high fat diet (hfd) feeding, bat mr knockout (bmrko) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to littermate control (lc) mice, although insulin resistance and fasting serum insulin were not significantly changed. |
2023-09-21 |
2023-10-07 |
mouse |
| Guanghong Jia, Michael Andrew Hill, James Sower. Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease. Journal of molecular endocrinology. 2023-08-23. PMID:37610001. |
recent research indicates that excessive production of aldosterone and associated activation of mineralocorticoid receptors (mr) impair insulin metabolic signaling, promote insulin resistance, and increase the risk of developing metabolic syndrome and cvd. |
2023-08-23 |
2023-09-07 |
Not clear |
| Javad Habibi, Carlton Homan, Huma Naz, Dongqing Chen, Guido Lastra, Adam Whaley-Connell, James R Sowers, Guanghong Ji. Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females. Endocrinology. 2023-06-08. PMID:37289042. |
here, we further investigated whether endothelial cell (ec) specific mr (ecmr) activation participates in wd-induced ectopic skeletal muscle lipid accumulation, insulin resistance and dysfunction. |
2023-06-08 |
2023-08-14 |
mouse |
| Misha Antani, Chirantap Oza, Vaman Khadilkar, Ketan Gondhalekar, Anuradha Khadilka. Utility of apolipoprotein ratio in predicting metabolic risk and microvascular complications in Indian children and young adults with type 1 diabetes mellitus. Journal of pediatric endocrinology & metabolism : JPEM. 2023-05-04. PMID:37141397. |
to assess the relationship of apolipoproteins with glycemic control and insulin resistance (ir) in indian children and youth with type-1 diabetes (t1d) and to assess its utility in predicting metabolic risk (mr) and microvascular complications in these subjects. |
2023-05-04 |
2023-08-14 |
human |
| Alessandra Feraco, Stefania Gorini, Caterina Mammi, Mauro Lombardo, Andrea Armani, Massimiliano Capri. Neutral Effect of Skeletal Muscle Mineralocorticoid Receptor on Glucose Metabolism in Mice. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108574. |
to confirm this hypothesis, we investigated the effects of mr blockade on insulin signaling in a cellular model of irin c2c12 myocytes, which were treated with or without spiro. |
2023-04-28 |
2023-08-14 |
mouse |
| Alessandra Feraco, Stefania Gorini, Caterina Mammi, Mauro Lombardo, Andrea Armani, Massimiliano Capri. Neutral Effect of Skeletal Muscle Mineralocorticoid Receptor on Glucose Metabolism in Mice. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108574. |
taken together, our data indicate that reduced activity of sm mr does not improve insulin signaling in mouse skeletal myocytes and does not contribute to the favorable metabolic effects on glucose tolerance and ir induced by systemic pharmacological mr blockade. |
2023-04-28 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
our findings showed that mr increased b-cell lymphoma-2 (bcl-2) expression, deceased bcl-2 associated x protein (bax), cleaved cysteinyl aspartate-specific proteinase-3 (caspase-3) expression in pancreas, and promoted insulin secretion of \xce\xb2-tc6 cells. |
2023-03-30 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
in conclusion, mr alleviates pancreatic apoptosis and promotes insulin secretion. |
2023-03-30 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Guoqing Wu, Yonghui Shi, Yueting Ge, Bowen Li, Xiangrong Cheng, Xue Tang, Jianjin Zhu, Guowei L. Dietary Methionine Restriction Improves Gastrocnemius Muscle Glucose Metabolism through Improved Insulin Secretion and H19/IRS-1/Akt Pathway in Middle-Aged Mice. Journal of agricultural and food chemistry. 2023-03-30. PMID:36995760. |
and mr enhances gastrocnemius muscle insulin-dependent glucose uptake and utilization via the h19/irs-1/akt pathway, thereby ameliorating blood glucose disorders and insulin resistance in high-fat-diet (hfd) middle-aged mice. |
2023-03-30 |
2023-08-14 |
mouse |
| Zikai Lin, Junfeng Huang, Shuojia Xie, Ziwen Zheng, Kailun Tang, Shiyue Li, Ruchong Che. The Association Between Insulin Use and Asthma: An Epidemiological Observational Analysis and Mendelian Randomization Study. Lung. 2023-03-27. PMID:36971839. |
this study aimed to investigate the association between insulin use and asthma in a large population-based cohort, and further explore their causal relationship by mendelian randomization (mr) analysis. |
2023-03-27 |
2023-08-14 |
Not clear |
| Jing Li, Mingyi Yang, Pan Luo, Gang Wang, Buhuai Dong, Peng X. Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis. Frontiers in genetics. vol 14. 2023-03-10. PMID:36896238. |
this study aims to explore the genetic causal association between type 2 diabetes (t2d) and glycemic traits (fasting glucose [fg], fasting insulin [fi], and glycated hemoglobin [hba1c]) on delirium using mendelian randomization (mr). |
2023-03-10 |
2023-08-14 |
human |
| Eloi Gagnon, Patricia L Mitchell, Benoit J Arsenaul. Body fat distribution, fasting insulin levels and insulin secretion: A bidirectional Mendelian randomization study. The Journal of clinical endocrinology and metabolism. 2022-12-31. PMID:36585897. |
here, we tested the direction of the causal effects of fasting insulin (fi) levels, body fat accumulation/distribution using two-sample bidirectional mendelian randomization (mr). |
2022-12-31 |
2023-08-14 |
Not clear |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
in vivo, mr inhibited the damage and apoptosis of hippocampal neurons caused by a high-fat diet, reduced hippocampal oxidative stress, improved hippocampal glucose metabolism, relieved insulin resistance, and enhanced cognitive ability. |
2022-11-11 |
2023-08-14 |
mouse |
| Karlijn A C Meeks, Amy R Bentley, Ayo P Doumatey, Adebowale A Adeyemo, Charles N Rotim. Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans. Scientific reports. vol 12. issue 1. 2022-11-08. PMID:36347891. |
the prs was used as the instrumental variable in two-stage least-squares mr analysis to assess its association with insulin resistance, hdl, ldl, total cholesterol, triglycerides, blood pressure, type 2 diabetes (t2d), and hypertension. |
2022-11-08 |
2023-08-14 |
Not clear |
| Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Ji. Mineralocorticoid receptors mediates diet - induced lipid infiltration of skeletal muscle and insulin resistance. Endocrinology. 2022-08-30. PMID:36039677. |
however, our understanding of the precise mechanisms by which enhanced mr activation promotes skeletal muscle insulin resistance remains unclear. |
2022-08-30 |
2023-08-14 |
mouse |
| Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Ji. Mineralocorticoid receptors mediates diet - induced lipid infiltration of skeletal muscle and insulin resistance. Endocrinology. 2022-08-30. PMID:36039677. |
in this study we investigated the mechanisms by which enhanced mr signaling in soleus muscle promotes ectopic skeletal muscle lipid accumulation and related insulin resistance. |
2022-08-30 |
2023-08-14 |
mouse |
| Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Ji. Mineralocorticoid receptors mediates diet - induced lipid infiltration of skeletal muscle and insulin resistance. Endocrinology. 2022-08-30. PMID:36039677. |
furthermore, mr signaling also mediated wd/aldosterone-induced reductions in soleus microrna (mir)-99a, which was identified to negatively target cd36 and prevented palmitic acid - induced increases in cd36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in c2c12 cells. |
2022-08-30 |
2023-08-14 |
mouse |
| Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Ji. Mineralocorticoid receptors mediates diet - induced lipid infiltration of skeletal muscle and insulin resistance. Endocrinology. 2022-08-30. PMID:36039677. |
these data indicate that inhibition of mr activation with spironolactone prevented diet - induced abnormal expression of mir-99a, which had the capacity to reduce cd36, leading to reduced imc lipid content, improved soleus mitochondria function and insulin sensitivity. |
2022-08-30 |
2023-08-14 |
mouse |