| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chitrakshi Pant, Genji Sukumar, Vidya Jyothi Alli, Surender Singh Jadav, Srihari Pabbaraja, Shasi V Kalivend. Allosteric Activation of SIRT1 by 2,4-Dihydroxy-azaflavanone Averts MPP ACS chemical neuroscience. 2024-07-29. PMID:39074306. |
allosteric activation of sirt1 by 2,4-dihydroxy-azaflavanone averts mpp parkinson's disease (pd) is a complex neurodegenerative disorder that affects dopamine neurons of the substantia nigra pars compacta (snpc), resulting in motor dysfunction. |
2024-07-29 |
2024-08-02 |
Not clear |
| Jingyi Li, Longmin Chen, Qixiong Qin, Danlei Wang, Jingwei Zhao, Hongling Gao, Xiao Yuan, Jing Zhang, Yuan Zou, Zhijuan Mao, Yongjie Xiong, Zhe Min, Manli Yan, Cong-Yi Wang, Zheng Xu. Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiology of disease. 2022-01-01. PMID:34973450. |
in this study, we examined the expression of hexokinase 2 (hk2) and lactate dehydrogenase (ldh), the key enzymes in glycolysis, and lactate levels in the substantia nigra pars compacta (snpc) of a mptp-induced mouse model of pd and in mpp |
2022-01-01 |
2023-08-13 |
mouse |
| Liping Bai, Fang Yan, Ruhua Deng, Rou Gu, Xianwen Zhang, Jie Ba. Thioredoxin-1 Rescues MPP Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33634378. |
thioredoxin-1 rescues mpp parkinson's disease (pd), a common neurodegenerative disease, is typically associated with the loss of dopaminergic neuron in the substantia nigra pars compacta (snpc). |
2021-07-06 |
2023-08-13 |
Not clear |
| Shu Yao, Longjun Li, Xin Sun, Jun Hua, Keqi Zhang, Li Hao, Lixin Liu, Dongyan Shi, Hong Zho. FTY720 Inhibits MPP Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:31069623. |
fty720 inhibits mpp parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons and excessive microglial activation in the substantia nigra pars compacta (snpc). |
2020-09-18 |
2023-08-13 |
mouse |
| Jianzhong Zhu, Shan Wang, Weiwei Qi, Xue Xu, Yingyin Lian. Overexpression of miR-153 promotes oxidative stress in MPP International journal of clinical and experimental pathology. vol 11. issue 8. 2020-01-21. PMID:31949812. |
overexpression of mir-153 promotes oxidative stress in mpp increasing evidence points to oxidative stress as a chief mediator of parkinson's disease (pd) characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra. |
2020-01-21 |
2023-08-13 |
Not clear |
| Feng-Juan Jiao, Qing-Zhi Wang, Pei Zhang, Jian-Guo Yan, Zheng Zhang, Feng He, Qian Zhang, Ze-Xi Lv, Xiang Peng, Hong-Wei Cai, Bo Tia. CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP Scientific reports. vol 7. issue 1. 2019-01-23. PMID:28717189. |
cdk5-mediated phosphorylation of xbp1s contributes to its nuclear translocation and activation in mpp parkinson's disease (pd) is an irreversible and progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta. |
2019-01-23 |
2023-08-13 |
Not clear |
| Andrew G Yee, Sun-Min Lee, Morag R Hunter, Michelle Glass, Peter S Freestone, Janusz Lipsk. Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons. Neurotoxicology. vol 45. 2015-10-13. PMID:25193392. |
although mpp(+) (1-methyl-4-phenylpyridinium) has been widely used to damage dopaminergic neurons of the substantia nigra pars compacta (snc) and produce animal and cellular models of parkinson's disease, the action of this toxin on ion channels and electrophysiological properties of these neurons remains controversial. |
2015-10-13 |
2023-08-13 |
rat |
| Weihai Liu, Songzhi Kong, Qingfeng Xie, Jiyan Su, Wenjie Li, Huizhen Guo, Shanshan Li, Xuexuan Feng, Ziren Su, Yang Xu, Xiaoping La. Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. International journal of molecular medicine. vol 35. issue 3. 2015-10-05. PMID:25573459. |
parkinson's disease is recognized as the second most common neurodegenerative disorder after alzheimer's disease, characterized by the loss of dopominergic neurons in the substantia nigra pars compacta and can be experimentally mimicked by the use of the neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (mpp(+)), in in vitro models. |
2015-10-05 |
2023-08-13 |
rat |
| YuYing Huang, JunFang Chen, Ying Chen, YingHan Zhuang, Mu Sun, Thomas Behnisc. The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300734. |
moreover, the hippocampus contains dopaminergic fibers, which are projecting from the ventral tegmental area, sn and pars compacta and contain the whole machinery required for dopamine synthesis making them sensitive to mptp and mpp(+). |
2015-08-24 |
2023-08-13 |
mouse |
| A Masi, R Narducci, E Landucci, F Moroni, G Mannaion. MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. British journal of pharmacology. vol 169. issue 1. 2014-09-05. PMID:23323755. |
we tackled this issue by probing the effects of an acute application of mpp(+) on substantia nigra pars compacta (snc) dopamine (da) neurons. |
2014-09-05 |
2023-08-12 |
Not clear |
| Tao Chen, Jie Zhu, Chi Zhang, Kai Huo, Zhou Fei, Xiao-fan Jian. Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383239. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder, characterized by loss of dopominergic (da) neurons in substantia nigra pars compacta (snpc), and can be experimentally mimicked by the neurotoxin mpp(+) in vitro models. |
2013-07-17 |
2023-08-12 |
Not clear |
| Florian Nagel, Mathias Bähr, Gunnar P H Diet. Tyrosine hydroxylase-positive amacrine interneurons in the mouse retina are resistant against the application of various parkinsonian toxins. Brain research bulletin. vol 79. issue 5. 2009-08-21. PMID:19406215. |
possible reason for the survival of retinal amacrine cells after systemic mptp application was a less efficient conversion into toxic mpp(+) in the retina or a general higher resistance against toxic insults of retinal da neurons compared with da neurons in the substantia nigra pars compacta (snpc). |
2009-08-21 |
2023-08-12 |
mouse |
| Rebecca Banerjee, Sen Sreetama, Karuppagounder S Saravanan, Sailendra Nath Dey, Kochupurackal P Mohanakuma. Apoptotic mode of cell death in substantia nigra following intranigral infusion of the parkinsonian neurotoxin, MPP+ in Sprague-Dawley rats: cellular, molecular and ultrastructural evidences. Neurochemical research. vol 32. issue 7. 2007-09-17. PMID:17401660. |
in the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (snpc) region of rats following unilateral intranigral infusion of the active metabolite, 1-methyl-4-phenyl pyridinium ion (mpp(+)), which resulted in a dose-dependent and prolonged dopamine depletion in the ipsilateral striatum. |
2007-09-17 |
2023-08-12 |
rat |
| I Ghorayeb, P O Fernagut, L Hervier, B Labattu, B Bioulac, F Tiso. A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis. Neuroscience. vol 115. issue 2. 2003-01-23. PMID:12421620. |
the mean loss of dopaminergic cells in the ipsilateral substantia nigra pars compacta in mpp(+) rats was less marked (-48.8%) than in the 6-hydroxydopamine rats (-63.6%) and was not significant in quinolinic acid rats (-5.2%). |
2003-01-23 |
2023-08-12 |
rat |
| A M Canudas, B Friguls, A M Planas, C Gabriel, E Escubedo, J Camarasa, A Camins, M Pallà. MPP(+) injection into rat substantia nigra causes secondary glial activation but not cell death in the ipsilateral striatum. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964606. |
injection of mpp(+) into the substantia nigra causes extensive necrosis and anterograde degeneration of pars compacta dopaminergic neurons. |
2000-10-11 |
2023-08-12 |
rat |
| P K Sonsalla, G D Zeevalk, L Manzino, A Giovanni, W J Nickla. MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats. Journal of neurochemistry. vol 58. issue 5. 1992-05-11. PMID:1560247. |
(1991), the extended treatment of rats with mk-801 did not prevent mpp(+)-induced cell loss in the infused substantia nigra pars compacta or the dopamine depletion in the ipsilateral neostriatum at 7-11 days after mpp+ infusion. |
1992-05-11 |
2023-08-11 |
mouse |