| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Mirabelli, Eusebio Chiefari, Biagio Arcidiacono, Alessandro Salatino, Angelo Pascarella, Maurizio Morelli, Sara C Credendino, Francesco S Brunetti, Anna Di Vito, Adelaide Greco, Vincent Huin, Ferdinando Nicoletti, Giovanna M Pierantoni, Monica Fedele, Umberto Aguglia, Daniela P Foti, Antonio Brunett. HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance. EBioMedicine. vol 115. 2025-04-15. PMID:40233659. |
hmga1 deficiency: a pathogenic link between tau pathology and insulin resistance. |
2025-04-15 |
2025-04-18 |
Not clear |
| Priyanka Choudhary, Shilpa Kumari, Kajal Bagri, Rahul Deshmuk. Ceramide: a central regulator in Alzheimer's disease pathogenesis. Inflammopharmacology. 2025-03-28. PMID:40148603. |
high ceramide levels are linked to the progression of ad pathology, significantly contributing to amyloid β (aβ) accumulation, tau tangle formation, insulin resistance, oxidative stress, and neuroinflammation. |
2025-03-28 |
2025-03-30 |
Not clear |
| Marialuisa de Ceglia, Nabila Rasheed, Rubén Tovar, Inés Pareja-Cerbán, Andrea Arias-Sáez, Ana Gavito, Silvana Gaetani, Carlo Cifani, Fernando Rodríguez de Fonseca, Juan Decar. A Combined GLP-1/PPARa/CB1-Based Therapy to Restore the Central and Peripheral Metabolic Dysregulation Induced by a High-Fructose High-Fat Diet. International journal of molecular sciences. vol 26. issue 6. 2025-03-27. PMID:40141063. |
in the brain, the hfhfd provoked disruptions in the expression of proteins regulating food intake, the endocannabinoid system, the insulin pathway, and inflammation and resulted in altered tau expression and phosphorylation, thus indicating neurodegenerative changes. |
2025-03-27 |
2025-03-30 |
rat |
| Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgio. Blood-based biomarkers in mild behavioral impairment: an updated overview. Frontiers in neurology. vol 16. 2025-02-21. PMID:39980634. |
in this context, mbi has been associated with lower plasma aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (nfl) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. |
2025-02-21 |
2025-02-23 |
Not clear |
| Meifang Xu, Liyuan Wang, Yun Meng, Guiqiong Kang, Qing Jiang, Tao Yan, Fengyuan Ch. The role of lipid metabolism in cognitive impairment. Arquivos de neuro-psiquiatria. vol 83. issue 1. 2025-01-15. PMID:39814004. |
generally, abnormalities in lipid metabolism can affect amyloid-beta (aβ) deposition, tau hyperphosphorylation, and insulin resistance through lipid metabolic signaling cascades; affect the neuronal membrane structure, neurotransmitter synthesis and release; and promote synapse growth, which can impact neural signal transmission and exacerbate disease progression in individuals with cognitive impairment, including ad, dci, and vd. |
2025-01-15 |
2025-01-19 |
Not clear |
| Meifang Xu, Liyuan Wang, Yun Meng, Guiqiong Kang, Qing Jiang, Tao Yan, Fengyuan Ch. The role of lipid metabolism in cognitive impairment. Arquivos de neuro-psiquiatria. vol 83. issue 1. 2025-01-15. PMID:39814004. |
the present article mainly discusses how lipid metabolic disorders in the brain microenvironment are involved in regulating the progression of cognitive impairment, and it explores the regulatory effects of targeting the key lipid transport protein apoe in the context of the role of lipid metabolism in the common pathogenesis of three diseases-aβ deposition, tau hyperphosphorylation, and insulin resistance-which will help elucidate the potential of targeting lipid metabolism for the treatment of cognitive impairment. |
2025-01-15 |
2025-01-19 |
Not clear |
| Sheer A Joodi, Weam W Ibrahim, Mahmoud M Khatta. Drugs repurposing in the experimental models of Alzheimer's disease. Inflammopharmacology. 2025-01-03. PMID:39752040. |
we illustrated the biological alterations in the pathophysiology of ad including the amyloid pathology, the tau pathology, oxidative stress, mitochondrial dysfunction, neuroinflammation, glutamate-mediated excitotoxicity, insulin signaling impairment, wingless-related integration site/β-catenin signaling, and autophagy. |
2025-01-03 |
2025-01-05 |
Not clear |
| Rashi Kumar, Ritu Varshney, Sharad Gupt. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751321. |
the study aimed to investigate the relationship between tau pathology and insulin resistance by quantifying glut4 expression and glucose concentration. |
2025-01-03 |
2025-01-05 |
Not clear |
| Ana W Capuano, Vishal Sarsani, Shinya Tasaki, Rupal I Mehta, Jun Li, Rexford Ahima, Steven Arnold, David A Bennett, Vladislav Petyuk, Liming Liang, Zoe Arvanitaki. Brain phosphoproteomic analysis identifies diabetes-related substrates in Alzheimer's disease pathology in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-12-28. PMID:39732516. |
insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of ad pathology. |
2024-12-28 |
2024-12-31 |
human |
| Dina Medina-Vera, Antonio J López-Gambero, Julia Verheul-Campos, Juan A Navarro, Laura Morelli, Pablo Galeano, Juan Suárez, Carlos Sanjuan, Beatriz Pacheco-Sánchez, Patricia Rivera, Francisco J Pavon-Morón, Cristina Rosell-Valle, Fernando Rodríguez de Fonsec. Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis. Nutrients. vol 16. issue 23. 2024-12-17. PMID:39683582. |
ad involves multiple pathological processes, including amyloid beta (aβ) deposition, insulin resistance, tau protein hyperphosphorylation, and systemic inflammation accelerated by gut microbiota dysbiosis originating from a leaky gut. |
2024-12-17 |
2024-12-21 |
mouse |
| Gemma García-Lluch, Anna Marseglia, Lucrecia Moreno Royo, Juan Pardo Albiach, Mar Garcia-Zamora, Miquel Baquero, Carmen Peña-Bautista, Lourdes Álvarez, Eric Westman, Consuelo Cháfer-Pericá. Associations between antidiabetic medications and cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2024-12-17. PMID:39686618. |
it has been hypothesized that insulin resistance is pivotal in mediating amyloid and tau dysregulations in alzheimer's disease (ad). |
2024-12-17 |
2024-12-21 |
Not clear |
| Pragati, Surajit Sarka. Targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mTOR/4EBP/S6K pathway in Drosophila. Brain research. 2024-11-23. PMID:39579954. |
targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mtor/4ebp/s6k pathway in drosophila. |
2024-11-23 |
2024-11-26 |
human |
| Pragati, Surajit Sarka. Targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mTOR/4EBP/S6K pathway in Drosophila. Brain research. 2024-11-23. PMID:39579954. |
we have recently reported that tissue-specific downregulation of insulin signaling or its growth-promoting downstream sub-branch effectively reinstates the tau-mediated overactivated insulin pathway, and restricts pathogenic tau hyperphosphorylation and aggregate formation. |
2024-11-23 |
2024-11-26 |
human |
| Pragati, Surajit Sarka. Targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mTOR/4EBP/S6K pathway in Drosophila. Brain research. 2024-11-23. PMID:39579954. |
we further report that expression of human tau in drosophila causes induction of the mtor/4ebp/s6k pathway and energy disbalance which gets effectively balanced upon downregulation of insulin signaling. |
2024-11-23 |
2024-11-26 |
human |
| Pragati, Surajit Sarka. Targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mTOR/4EBP/S6K pathway in Drosophila. Brain research. 2024-11-23. PMID:39579954. |
our findings establish an imperative role of insulin signaling in effectively mitigating various aspects of tau etiology in drosophila ranging from hyperphosphorylation, chromatin relaxation, and translational upsurge. |
2024-11-23 |
2024-11-26 |
human |
| I Hyun Ruisch, Joanna Widomska, Ward De Witte, Nina R Mota, Giuseppe Fanelli, Veerle Van Gils, Willemijn J Jansen, Stephanie J B Vos, Abel Fóthi, Csaba Barta, Simone Berkel, Kazi A Alam, Aurora Martinez, Jan Haavik, Aet O'Leary, David Slattery, Mairéad Sullivan, Jeffrey Glennon, Jan K Buitelaar, Janita Bralten, Barbara Franke, Geert Poelman. Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-28. PMID:39465382. |
from the landscape, multiple functional themes emerged, including insulin signaling, estrogen signaling, synaptic transmission, lipid metabolism and tau signaling. |
2024-10-28 |
2024-10-30 |
Not clear |
| Marilyn J Steinbach, Natalie L Denbur. Melatonin in Alzheimer's Disease: Literature Review and Therapeutic Trials. Journal of Alzheimer's disease : JAD. vol 101. issue s1. 2024-10-18. PMID:39422936. |
this review covers basic biology and clinical research on melatonin in ad focusing on prominent hypotheses of pathophysiology of neurodegeneration and cognitive decline in ad (i.e., amyloid and tau hypotheses, antioxidant and anti-inflammation, insulin resistance and glucose homeostasis, the cholinergic hypothesis, sleep regulation, and the hypothalamic-pituitary-adrenal axis and cortisol). |
2024-10-18 |
2024-10-20 |
Not clear |
| Reji Babygirija, Jessica H Han, Michelle M Sonsalla, Ryan Matoska, Mariah F Calubag, Cara L Green, Anna Tobon, Chung-Yang Yeh, Diana Vertein, Sophia Schlorf, Julia Illiano, Yang Liu, Isaac Grunow, Michael J Rigby, Luigi Puglielli, David A Harris, John M Denu, Dudley W Lammin. Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386545. |
however, we find that a prolonged fast between meals is necessary for many of the benefits of cr, including improved insulin sensitivity, reduced phosphorylation of tau, decreased neuroinflammation, inhibition of mtorc1 signaling, and activation of autophagy, as well as for the full cognitive benefits of cr. |
2024-10-10 |
2024-10-12 |
mouse |
| Haripriya S, Tamilanban T, Chitra Vellapandia. Gut-Brain Axis: Unveiling the Interplay Between Diabetes Mellitus and Alzheimer's Disease. Cureus. vol 16. issue 8. 2024-09-30. PMID:39347125. |
key mechanisms include insulin resistance affecting neuronal function and promoting amyloid-beta accumulation and tau phosphorylation, hallmark features of ad. |
2024-09-30 |
2024-10-02 |
Not clear |
| Mansour Azimzadeh, Pike-See Cheah, King-Hwa Lin. Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target. Biochemical and biophysical research communications. vol 733. 2024-09-22. PMID:39307112. |
these include heightened desensitisation of brain insulin and insulin-like growth factor-1 (igf-1) reactions, compromised mitochondrial functionality, escalated oxidative stress, reduced autophagy, and the accumulation of amyloid beta and tau phosphorylation. |
2024-09-22 |
2024-09-26 |
Not clear |