| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haripriya S, Tamilanban T, Chitra Vellapandia. Gut-Brain Axis: Unveiling the Interplay Between Diabetes Mellitus and Alzheimer's Disease. Cureus. vol 16. issue 8. 2024-09-30. PMID:39347125. |
key mechanisms include insulin resistance affecting neuronal function and promoting amyloid-beta accumulation and tau phosphorylation, hallmark features of ad. |
2024-09-30 |
2024-10-02 |
Not clear |
| Mansour Azimzadeh, Pike-See Cheah, King-Hwa Lin. Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target. Biochemical and biophysical research communications. vol 733. 2024-09-22. PMID:39307112. |
these include heightened desensitisation of brain insulin and insulin-like growth factor-1 (igf-1) reactions, compromised mitochondrial functionality, escalated oxidative stress, reduced autophagy, and the accumulation of amyloid beta and tau phosphorylation. |
2024-09-22 |
2024-09-26 |
Not clear |
| Verónica Hurtado-Carneiro, Yannick LeBaut-Ayuso, Esther Velázquez, Cinthya Flores-Lamas, Rubén Fernández-de la Rosa, Luis García-García, Francisca Gómez-Oliver, Juan Miguel Ruiz-Albusac, Miguel Ángel Poz. Effects of chronic treatment with metformin on brain glucose hypometabolism and central insulin actions in transgenic mice with tauopathy. Heliyon. vol 10. issue 15. 2024-08-22. PMID:39170185. |
our results demonstrated that 12-old months tau mice exhibited brain glucose hypometabolism as well as basal hyperglycemia, impaired glucose tolerance, hyperinsulinemia, and signs of insulin resistance. |
2024-08-22 |
2024-08-24 |
mouse |
| Aarti Nagayach, Rakesh Bhaskar, Shampa Ghosh, Krishna Kumar Singh, Sung Soo Han, Jitendra Kumar Sinh. Advancing the Understanding of Diabetic Encephalopathy through Unravelling Pathogenesis and Exploring Future Treatment Perspectives. Ageing research reviews. 2024-08-12. PMID:39134179. |
the pivotal roles of various cellular pathways, activated or influenced by hyperglycemia, insulin sensitivity, amyloid accumulation, tau hyperphosphorylation, brain vasculopathy, neuroinflammation, and oxidative stress, are widely recognized for contributing to the potential causes of diabetic encephalopathy. |
2024-08-12 |
2024-08-16 |
Not clear |
| Mona Mohamed Ibrahim Abdall. Insulin resistance as the molecular link between diabetes and Alzheimer's disease. World journal of diabetes. vol 15. issue 7. 2024-08-05. PMID:39099819. |
when insulin signalling becomes dysfunctional, it can negatively affect various brain functions, making individuals more susceptible to ad's defining features, such as the buildup of beta-amyloid plaques and tau protein tangles. |
2024-08-05 |
2024-08-07 |
Not clear |
| Isabella Supardi Parida, Soo Takasu, Junya Ito, Takahiro Eitsuka, Kiyotaka Nakagaw. 1-Deoxynojirimycin attenuates pathological markers of Alzheimer's disease in the in vitro model of neuronal insulin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 13. 2024-07-09. PMID:38979931. |
dnj appeared to mitigate the insulin resistance-driven increase in phosphorylated tau and aβ |
2024-07-09 |
2024-07-12 |
human |
| Yong Peng, Shun-Yu Yao, Quan Chen, Hong Jin, Miao-Qiao Du, Ya-Hui Xue, Shu Li. True or False? Alzheimer's disease is Type 3 Diabetes: Evidences from Bench to Bedside. Ageing research reviews. 2024-07-02. PMID:38955264. |
this has propelled researchers to investigate the mechanism(s) underlying this connection.a critical review of the relationship between insulin resistance, aβ, oxidative stress, mitochondrial hypothesis, abnormal phosphorylation of tau protein, inflammatory response, high blood glucose levels, neurotransmitters and signaling pathways, vascular issues in ad and diabetes, and the similarities between the two diseases, is presented in this review. |
2024-07-02 |
2024-07-06 |
Not clear |
| Geoffrey Canet, Maud Gratuze, Charleine Zussy, Mohamed Lala Bouali, Sofia Diego Diaz, Emma Rocaboy, Francis Laliberté, Noura B El Khoury, Cyntia Tremblay, Françoise Morin, Frédéric Calon, Sébastien S Hébert, Carl Julien, Emmanuel Plane. Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice. Neurobiology of disease. 2024-05-11. PMID:38734152. |
our study aimed to fill this gap by analyzing the impact of insulin dysfunction in 7 and 23 months 3xtg-ad mice, that exhibit both amyloid and tau pathologies. |
2024-05-11 |
2024-05-27 |
mouse |
| Geoffrey Canet, Maud Gratuze, Charleine Zussy, Mohamed Lala Bouali, Sofia Diego Diaz, Emma Rocaboy, Francis Laliberté, Noura B El Khoury, Cyntia Tremblay, Françoise Morin, Frédéric Calon, Sébastien S Hébert, Carl Julien, Emmanuel Plane. Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice. Neurobiology of disease. 2024-05-11. PMID:38734152. |
stz administration led to insulin deficiency in the younger mice, resulting in an increase in cortical amyloid-β (aβ) and tau aggregation, while tau phosphorylation was not significantly affected. |
2024-05-11 |
2024-05-27 |
mouse |
| Samar R Saleh, Aml Abd-Elmegied, Somaya Aly Madhy, Sherine N Khattab, Eman Sheta, Fatma Y Elnozahy, Radwa A Mehanna, Doaa A Ghareeb, Nihad M Abd-Elmone. Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis. International journal of pharmaceutics. 2024-05-11. PMID:38734273. |
icv-stz injection produces ad-like pathologies evidenced by aβ42 deposition, tau hyperphosphorylation, impaired insulin signaling and neuroplasticity, and neuroinflammation. |
2024-05-11 |
2024-05-27 |
rat |
| Zhengzhong Zeng, Hu Zhang, Xianping Wang, Jiawen Shen, Danyang Che. Fasting, a Potential Intervention in Alzheimer's Disease. Journal of integrative neuroscience. vol 23. issue 3. 2024-03-27. PMID:38538214. |
the clinical efficacy of fasting in addressing ad and related disorders might be grounded in its influence on various molecular mechanisms, including neuroinflammation, glial cell activation, insulin resistance, autophagy regulation, nerve regeneration, the gut microbiome, and accumulations of amyloid-β and tau proteins. |
2024-03-27 |
2024-03-30 |
human |
| Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M Hoyos, Ole Tietz, Hui Xin Ong, Daniela Train. Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy. Drug delivery and translational research. 2024-03-05. PMID:38441832. |
notably, intranasal insulin has shown neuroprotective effects, impacting aβ clearance, tau phosphorylation, and synaptic plasticity. |
2024-03-05 |
2024-03-07 |
Not clear |
| Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevell. Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling. Molecular neurobiology. 2024-03-02. PMID:38430352. |
treatment with blackberry extract and metformin in sporadic alzheimer's disease model: impact on memory, inflammation, redox status, phosphorylated tau protein and insulin signaling. |
2024-03-02 |
2024-03-04 |
rat |
| Veerle van Gils, Marianna Rizzo, Jade Côte, Wolfgang Viechtbauer, Giuseppe Fanelli, Jordi Salas-Salvadó, Theresa Wimberley, Mònica Bulló, Fernando Fernandez-Aranda, Søren Dalsgaard, Pieter Jelle Visser, Willemijn J Jansen, Stephanie J B Vo. The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis. Neuroscience and biobehavioral reviews. 2024-02-29. PMID:38423195. |
therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated haemoglobin, fasting blood glucose, insulin resistance indices) and dm status with ad biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. |
2024-02-29 |
2024-03-03 |
Not clear |
| Yang Hai, Ke Ren, Yarong Zhang, Lili Yang, Haoshi Cao, Xianxia Yuan, Linling Su, Hailong Li, Xiaoli Feng, Dongling Li. HIF-1α serves as a co-linker between AD and T2DM. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-19. PMID:38242039. |
tissue oxygen consumption disrupts hif-1α homeostasis, leading to increased reactive oxygen species levels and the inhibition of insulin receptor pathway activity, causing neuroinflammation, insulin resistance, abnormal aβ deposition, and tau hyperphosphorylation. |
2024-01-19 |
2024-01-22 |
Not clear |
| Abhinbhen W Saraya, Chavit Tunvirachaisakul, Chanikarn Sonpee, Panticha Katasrila, Tanyares Sathaporn, Supatporn Tepmongkol, Sookjareon Tangwongcha. Serum proinsulin levels as peripheral blood biomarkers in patients with cognitive impairment. Scientific reports. vol 13. issue 1. 2023-12-19. PMID:38105338. |
insulin affecting the clearance of amyloid-β peptide and phosphorylation of tau in the cns. |
2023-12-19 |
2023-12-21 |
human |
| Hamed A Abosharaf, Yasmin Elsonbaty, Ehab Tousson, Tarek M Mohame. Alzheimer's disease-related brain insulin resistance and the prospective therapeutic impact of metformin. Journal of neuroendocrinology. 2023-11-20. PMID:37985011. |
we then measured glucose, insulin receptor substrate 2 (irs-2), amyloid β (aβ) deposition, and tau phosphorylation in the brain to look for signs of insulin resistance and ad. |
2023-11-20 |
2023-11-29 |
rat |
| A Young Sim, Da Hyun Choi, Jong Youl Kim, Eun Ran Kim, A-Ra Goh, Yong-Ho Lee, Jong Eun Le. SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-23. PMID:37871560. |
interestingly, sglt2-i and dpp4-i reduced the hyperphosphorylated tau (ptau) levels and amyloid β (aβ) accumulation and enhanced brain insulin signaling. |
2023-10-23 |
2023-11-08 |
mouse |
| Jennifer Erichsen, Suzanne Craf. Targeting immunometabolic pathways for combination therapy in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 9. issue 4. 2023-10-03. PMID:37786483. |
additional effects of insulin and metabolic modulators demonstrated in preclinical and clinical studies of ad include increased clearance of amyloid-β, slowed tau progression, improved vascular function and lipid metabolism, reduced synaptotoxicity, and improved cognitive and functional outcomes. |
2023-10-03 |
2023-10-07 |
Not clear |
| Salvatore P Mangiafico, Qing-Zhang Tuo, Xiao-Lan Li, Yu Liu, Christian Haralambous, Xu-Long Ding, Scott Ayton, Qing Wang, D Ross Laybutt, Jeng Yie Chan, Xiang Zhang, Cameron Kos, Helen E Thomas, Thomas Loudovaris, Chieh-Hsin Yang, Christos N Joannides, Benjamin J Lamont, Lunzhi Dai, Hai-Huai He, Biao Dong, Sofianos Andrikopoulos, Ashley I Bush, Peng Le. Tau suppresses microtubule-regulated pancreatic insulin secretion. Molecular psychiatry. 2023-09-22. PMID:37735502. |
tau suppresses microtubule-regulated pancreatic insulin secretion. |
2023-09-22 |
2023-10-07 |
mouse |