| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. |
2024-07-03 |
2024-07-10 |
mouse |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
our study collectively provides evidence of the effectiveness of nasal tau immunotherapy in targeting and clearing intracellular tau pathology through trim21 and enhancing cognition in aged tauopathy mice. |
2024-07-03 |
2024-07-10 |
mouse |
| Soraya Meftah, Claire S Durrant, Tara L Spires-Jone. A nose for tau. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959325. |
nasal delivery of an oligomeric tau antibody loaded into micelles reduces pathology and ameliorates cognition in a mouse model of tauopathy. |
2024-07-03 |
2024-07-10 |
mouse |
| Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhan. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897723. |
furthermore, intranasal infection of s. cerevisiae in the nasal cavity of tau p301s mice accelerates the aggregation of tau. |
2023-10-28 |
2023-11-08 |
mouse |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
nasal administration of wttidm in p301s tau-expressing ps19 mice was found to inhibit gliosis and inflammatory markers, along with reduction of pathogenic tau in the hippocampus, resulting in improved cognitive behavior in ps19 mice. |
2023-08-08 |
2023-08-16 |
mouse |
| Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming X. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases. Translational neurodegeneration. vol 12. issue 1. 2023-03-16. PMID:36922862. |
in neurodegenerative diseases, nasal swab tests are currently being explored using seed amplification assay (saa) of pathogenic misfolded proteins, such as prion, α-synuclein, and tau. |
2023-03-16 |
2023-08-14 |
Not clear |
| Ryoichi Inoue, Masanori Sawamura, Michio Yoshimura, Ryosuke Takahash. Dropped head syndrome due to chemoradiotherapy for nasal lymphoma, characterised by short tau inversion recovery high signal intensity in the cervical paraspinal muscles. BMJ case reports. vol 15. issue 11. 2022-11-11. PMID:36368727. |
dropped head syndrome due to chemoradiotherapy for nasal lymphoma, characterised by short tau inversion recovery high signal intensity in the cervical paraspinal muscles. |
2022-11-11 |
2023-08-14 |
Not clear |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
nasal rifampicin halts the progression of tauopathy by inhibiting tau oligomer propagation in alzheimer brain extract-injected mice. |
2022-02-25 |
2023-08-13 |
mouse |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
in the present study, we examined the effects of nasal rifampicin on tau propagation in a new mouse model of tauopathy. |
2022-02-25 |
2023-08-13 |
mouse |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
here, we developed vaccination against a secreted form of pathological tau linked to ftld-tau using a sendai virus (sev) vector infectious to host nasal mucosa, a key part of the immune system. |
2021-08-16 |
2023-08-13 |
mouse |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
although immunotherapies of these disorders against tau are emerging, it is unknown whether nasal delivery, which offers many benefits over traditional approaches to vaccine administration, is effective or not for tauopathy. |
2021-08-16 |
2023-08-13 |
mouse |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
tau vaccines given as nasal drops induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in ftld-tau model mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Aslina Pahrudin Arrozi, Daijiro Yanagisawa, Tomoko Kato, Hiroyasu Akatsu, Yoshio Hashizume, Daita Kaneda, Ikuo Tooyam. Nasal Extracts from Patients with Alzheimer's Disease Induce Tau Aggregates in a Cellular Model of Tau Propagation. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-06-12. PMID:34113783. |
nasal extracts from patients with alzheimer's disease induce tau aggregates in a cellular model of tau propagation. |
2021-06-12 |
2023-08-13 |
Not clear |
| Hui Mai, Weihao Fan, Yan Wang, Yujie Cai, Xiaohui Li, Feng Chen, Xiongjin Chen, Jingqi Yang, Pei Tang, Huiyi Chen, Ting Zou, Tingting Hong, Conghua Wan, Bin Zhao, Lili Cu. Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model. Molecular therapy. Nucleic acids. vol 18. 2021-01-10. PMID:31707205. |
in this study, using a noninvasive nasal administration, we discovered that a mir-146a agomir (m146ag) rescued cognitive impairment in the app/ps1 transgenic mouse and alleviated the overall pathological process in the ad mouse model, including neuroinflammation, glia activation, aβ deposit, and tau phosphorylation in hippocampi. |
2021-01-10 |
2023-08-13 |
mouse |
| Ziyi Liu, Naoko Kameshima, Toshifumi Nanjo, Akihiko Shiino, Tomoko Kato, Shino Shimizu, Takeshi Shimizu, Sachiko Tanaka, Katsuyuki Miura, Ikuo Tooyam. Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29480194. |
the pgd-ii method measured aβ42, total tau, and phosphorylated tau, but levels of aβ40 in all nasal locations of both groups were near zero. |
2019-02-08 |
2023-08-13 |
human |
| Ziyi Liu, Naoko Kameshima, Toshifumi Nanjo, Akihiko Shiino, Tomoko Kato, Shino Shimizu, Takeshi Shimizu, Sachiko Tanaka, Katsuyuki Miura, Ikuo Tooyam. Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29480194. |
development of a high-sensitivity method for the measurement of human nasal aβ42, tau, and phosphorylated tau. |
2019-02-08 |
2023-08-13 |
human |
| Ziyi Liu, Naoko Kameshima, Toshifumi Nanjo, Akihiko Shiino, Tomoko Kato, Shino Shimizu, Takeshi Shimizu, Sachiko Tanaka, Katsuyuki Miura, Ikuo Tooyam. Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29480194. |
median levels of phosphorylated tau to total tau (p-tau/t-tau) ratios in the middle nasal meatus and in the olfactory cleft were significantly higher in ad cases than in controls, and could significantly predict ad. |
2019-02-08 |
2023-08-13 |
human |
| Ziyi Liu, Naoko Kameshima, Toshifumi Nanjo, Akihiko Shiino, Tomoko Kato, Shino Shimizu, Takeshi Shimizu, Sachiko Tanaka, Katsuyuki Miura, Ikuo Tooyam. Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29480194. |
the pgd-i method measured total tau and amyloid-β (aβ)42, but no differences in median levels of total tau and aβ42 between ad cases and controls were found in any of the nasal locations. |
2019-02-08 |
2023-08-13 |
human |
| Rolf Anckarsäter, Henrik Anckarsäter, Sara Bromander, Kaj Blennow, Caroline Wass, Henrik Zetterber. Non-neurological surgery and cerebrospinal fluid biomarkers for neuronal and astroglial integrity. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 6. 2015-01-07. PMID:24420082. |
inflammatory biomarkers, total tau (t-tau) and phosphorylated tau (p-tau) were recently shown to increase progressively in the cerebrospinal fluid (csf) during surgery for nasal csf leak, suggesting a neuroinflammatory response with signs of neuronal damage. |
2015-01-07 |
2023-08-12 |
Not clear |
| Fumihiko Tanak. Transient network theory of wormlike micelles: topological force accelerates relaxation. Langmuir : the ACS journal of surfaces and colloids. vol 26. issue 8. 2010-07-01. PMID:20384367. |
the high frequency plateau modulus g(infinity) and the relaxation time tau as functions of the micellar concentration are calculated and compared with the experimental data on the aqueous solutions of cetyltrimethylammonium bromide (ctab) mixed with ionic aromatic compound sodium salicylate (nasal). |
2010-07-01 |
2023-08-12 |
Not clear |