| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
effect of sleep deprivation by mmp-wm on rat neurological function and tau protein in hippocampus. |
2023-11-28 |
2023-11-29 |
human |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
this study aims to explore the effect of sleep deprivation by modified multiple platform-water maze (mmp-wm) on rat neurological function and tau protein in the hippocampus, as well as the intervention effect of remimazolam. |
2023-11-28 |
2023-11-29 |
human |
| Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. |
after that, the rats were executed, the hippocampus was isolated for nissl staining, and the protein expression of phosphorylated tau (p-tau) in the ca1 region of the hippocampus was measured by immunohistochemistry. |
2023-11-28 |
2023-11-29 |
human |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-M\\xc3\\xa1rquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
moreover, the effects of tau on mitochondrial function and oxidative stress biomarkers as plausible mechanisms of its action in the whole brain and hippocampus have been evaluated. |
2023-11-26 |
2023-11-28 |
mouse |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-M\\xc3\\xa1rquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
tau measurement in the brain and hippocampus revealed higher levels of this amino acid. |
2023-11-26 |
2023-11-28 |
mouse |
| Mohammad Mehdi Ommati, Heresh Rezaei, Retana-M\\xc3\\xa1rquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. |
tau and atp levels were also significantly higher in the mitochondria isolated from the whole brain and hippocampus. |
2023-11-26 |
2023-11-28 |
mouse |
| Hansol Lee, Jessie Fanglu Fu, Kyla Gaudet, Annie G Bryant, Julie C Price, Rachel E Bennett, Keith A Johnson, Bradley T Hyman, Trey Hedden, David H Salat, Yi-Fen Yen, Susie Y Huan. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-11-24. PMID:38000018. |
aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and alzheimer's disease. |
2023-11-24 |
2023-11-28 |
mouse |
| Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J O'Neill, Florian Wegner, Stefan Barghorn, G\\xc3\\xbcnter U H\\xc3\\xb6glinger, Roland G Hey. Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain. Acta neuropathologica communications. vol 11. issue 1. 2023-11-15. PMID:37964332. |
the specificity of our tau saa for ad brain was further supported by analysis of matched hippocampus and cerebellum samples. |
2023-11-15 |
2023-11-20 |
human |
| Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J O'Neill, Florian Wegner, Stefan Barghorn, G\\xc3\\xbcnter U H\\xc3\\xb6glinger, Roland G Hey. Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain. Acta neuropathologica communications. vol 11. issue 1. 2023-11-15. PMID:37964332. |
while seeding was detected in hippocampus from braak stages i-ii, no seeding was present in ad cerebellum that is devoid of tau inclusions. |
2023-11-15 |
2023-11-20 |
human |
| Claire J Ciampa, Thomas M Morin, Alice Murphy, Renaud La Joie, Susan M Landau, Anne S Berr. DAT1 and BDNF polymorphisms interact to predict A\\xce\\xb2 and tau pathology. Neurobiology of aging. vol 133. 2023-11-10. PMID:37948982. |
we tested for effects of dat1 and bdnf polymorphisms on cross-sectional and longitudinal \xce\xb2-amyloid (a\xce\xb2) and tau pathology (measured with positron emission tomography (pet)), hippocampal volume, and cognition. |
2023-11-10 |
2023-11-20 |
Not clear |
| Shanley F Longfield, Mahdie Mollazade, Tristan P Wallis, Rachel S Gormal, Merja Joensuu, Jesse R Wark, Ashley J van Waardenberg, Christopher Small, Mark E Graham, Fr\\xc3\\xa9d\\xc3\\xa9ric A Meunier, Ram\\xc3\\xb3n Mart\\xc3\\xadnez-M\\xc3\\xa1rmo. Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature communications. vol 14. issue 1. 2023-11-10. PMID:37949856. |
here, we performed a large-scale activity-dependent phosphoproteome analysis of hippocampal neurons in vitro and identified tau as a highly phosphorylated and disordered candidate protein. |
2023-11-10 |
2023-11-20 |
Not clear |
| Singh S Ankul, Lakshmi Chandran, Singh Anuragh, Ilango Kaliappan, Rapuru Rushendran, Chitra Vellapandia. A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model. Frontiers in pharmacology. vol 14. 2023-11-09. PMID:37942488. |
the treated mice also had more hyperphosphorylated tau protein in their cortical and hippocampus neurons. |
2023-11-09 |
2023-11-20 |
mouse |
| Olivia Lu, Taimur Kouser, Irina A Skylar-Scot. Alzheimer's disease and epilepsy: shared neuropathology guides current and future treatment strategies. Frontiers in neurology. vol 14. 2023-11-08. PMID:37936917. |
this bi-directional relationship may be due to underlying shared pathophysiologic hallmarks, including decreased cerebrospinal fluid amyloid beta 42 (a\xce\xb242), increased hyperphosphorylated tau protein, and hippocampal hyperexcitability. |
2023-11-08 |
2023-11-20 |
Not clear |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
linear mixed models examined the relationship between apoe profiles and brain changes (i.e., regional wmhs, ventricle size, hippocampal and entorhinal cortex volume, amyloid level, and phosphorylated tau measures), while controlling for age, sex, education, and diagnostic status at baseline and over time. |
2023-11-07 |
2023-11-20 |
human |
| Sophie Nader, Esma Karlovich, Etty P Cortes, Ricardo Insausti, Gregory Meloni, Michelle Jacobs, John F Crary, Susan Morgell. Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection. Journal of neurovirology. 2023-11-05. PMID:37926797. |
the accumulation of hyperphosphorylated tau (p-tau) in hippocampus is a common degenerative change, with specific patterns of hippocampal subfield vulnerability observed in different disease contexts. |
2023-11-05 |
2023-11-08 |
human |
| Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A Fernandez, Perle Roche, Emma L Bunting, Ella K Lacey, Sara E Hamplova, Monlan Yuan, Michael S Wolfe, David A Bennett, Eunjung A Lee, Bruce A Yankne. A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-11-03. PMID:37919281. |
conversely, viral-mediated overexpression of rest in the hippocampus suppresses a\xce\xb2 and tau pathology. |
2023-11-03 |
2023-11-08 |
mouse |
| Brian N Lee, Junwen Wang, Molly A Hall, Dokyoon Kim, Shana D Stites, Li She. Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease. Neurobiology of aging. vol 133. 2023-11-01. PMID:37913627. |
multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (av45), and csf (p-tau, tau) biomarkers were differentially associated with cognitive and functional outcomes. |
2023-11-01 |
2023-11-08 |
human |
| Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhan. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897723. |
when injected into the hippocampus of tau p301s transgenic mice, the ure2p-seeded tau fibrils show enhanced seeding activity compared with pure tau fibrils. |
2023-10-28 |
2023-11-08 |
mouse |
| Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. |
sarkosyl-insoluble-proteomic analyses of the ckd mouse hippocampus revealed an accumulation of insoluble mapt (microtubule-associated protein tau) and rna-binding proteins such as small nuclear ribonucleoprotein u1 subunit 70 (snrnp70). |
2023-10-27 |
2023-11-08 |
mouse |
| Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min L. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-24. PMID:37867176. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the brain. |
2023-10-24 |
2023-11-08 |
mouse |