| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kiharu Igarashi, Sho Kobayashi, Yasushi Mori, Makiko Takagi, Yoichi Fukushim. Effect of Dietary L-Theanine on Protein Expression in the Hippocampus of Senescence-Accelerated Mice (SAMP8). Journal of nutritional science and vitaminology. vol 70. issue 3. 2024-06-30. PMID:38945886. |
in addition to improvement in the aging score with theanine administration, in proteomics, significant suppressions in the expressions of synapsin 2, α-synuclein, β-synuclein, and protein tau were observed by theanine administration, and the expression of cam kinase ii beta and alpha exhibited a significant increase and increasing tendency with theanine administration, respectively. |
2024-06-30 |
2024-07-03 |
mouse |
| Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medin. Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease. Communications biology. vol 7. issue 1. 2024-05-04. PMID:38704445. |
furthermore, reconstructed eeg proxy quantities show the hallmark ad electrophysiological alterations (theta band activity enhancement and alpha reductions) which occur with aβ-positivity and after limbic tau involvement. |
2024-05-04 |
2024-05-07 |
Not clear |
| Matthew G Wisniewski, Chelsea N Joyner, Alexandria C Zakrzewski, Scott Makei. Finding tau rhythms in EEG: An independent component analysis approach. Human brain mapping. vol 45. issue 2. 2024-02-10. PMID:38339905. |
tau rhythms are largely defined by sound responsive alpha band (~8-13 hz) oscillations generated largely within auditory areas of the superior temporal gyri. |
2024-02-10 |
2024-02-12 |
human |
| Matthew G Wisniewski, Chelsea N Joyner, Alexandria C Zakrzewski, Scott Makei. Finding tau rhythms in EEG: An independent component analysis approach. Human brain mapping. vol 45. issue 2. 2024-02-10. PMID:38339905. |
these "tau ics" showed alpha suppression during sound presentations that was not seen for other commonly observed ic clusters with spectral peaks in the alpha range (e.g., those associated with somatomotor mu, and parietal or occipital alpha). |
2024-02-10 |
2024-02-12 |
human |
| Amanda Pasqualotto, Vinícius da Silva, Felipe Mateus Pellenz, Artur Francisco Schumacher Schuh, Ida Vanessa Doederlein Schwartz, Marina Sieber. Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach. Metabolic brain disease. 2024-02-02. PMID:38305999. |
as a hypothesis, we highlight as possible key genes for ap the mapt (microtubule associated protein tau), apoe (apolipoprotein e), snca (synuclein alpha) and app (amyloid beta precursor protein) genes. |
2024-02-02 |
2024-02-04 |
Not clear |
| Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medin. Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity decoder. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502947. |
furthermore, our results reproduce hallmark ad electrophysiological alterations (theta band activity enhancement and alpha reductions) which occur with aβ-positivity and after limbic tau involvement. |
2023-07-28 |
2023-08-14 |
human |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharm. Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer's Disease Brain Pathology Exacerbated by Sleep Deprivation. Advances in neurobiology. vol 32. 2023-07-22. PMID:37480458. |
nanowired delivery of cerebrolysin together with antibodies to amyloid beta peptide, phosphorylated tau, and tumor necrosis factor alpha induces superior neuroprotection in alzheimer's disease brain pathology exacerbated by sleep deprivation. |
2023-07-22 |
2023-08-14 |
Not clear |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharm. Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer's Disease Brain Pathology Exacerbated by Sleep Deprivation. Advances in neurobiology. vol 32. 2023-07-22. PMID:37480458. |
keeping these views in consideration in this review, nanodelivery of monoclonal antibodies to amyloid beta peptide (aβp), phosphorylated tau (p-tau), and tumor necrosis factor alpha (tnf-α) in sleep deprivation-induced ad is discussed based on our own investigations. |
2023-07-22 |
2023-08-14 |
Not clear |
| Anca D Buzoianu, Aruna Sharma, Dafin F Muresanu, Lianyuan Feng, Hongyun Huang, Lin Chen, Z Ryan Tian, Ala Nozari, José Vicente Lafuente, Lars Wiklund, Hari Shanker Sharm. Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease. Advances in neurobiology. vol 32. 2023-07-22. PMID:37480459. |
the hallmarks of pd include increased alpha synuclein (asnc) and phosphorylated tau (p-tau) in the cerebrospinal fluid (csf) leading to brain pathology. |
2023-07-22 |
2023-08-14 |
human |
| Prapti H Mody, Kelsey N Marvin, DiAnna L Hynds, Laura K Hanso. Cytomegalovirus infection induces Alzheimer's disease-associated alterations in tau. Journal of neurovirology. 2023-07-12. PMID:37436577. |
thus, we confirm that mcmv, a beta herpes virus, like alpha herpes viruses (e.g., hsv1), can promote tau pathology. |
2023-07-12 |
2023-08-14 |
mouse |
| Deborah N Schoonhoven, Emma M Coomans, Ana P Millán, Anne M van Nifterick, Denise Visser, Rik Ossenkoppele, Hayel Tuncel, Wiesje M van der Flier, Sandeep S V Golla, Philip Scheltens, Arjan Hillebrand, Bart N M van Berckel, Cornelis J Stam, Alida A Gou. Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study. Brain : a journal of neurology. 2023-06-06. PMID:37279597. |
tau propagation was modelled as an epidemic process (susceptible-infected model) on meg-based functional networks (in alpha (8-13hz) and beta (13-30hz) bands), a structural, or diffusion network, starting from the middle and inferior temporal lobe. |
2023-06-06 |
2023-08-14 |
human |
| Natalia A Muraleva, Nataliya G Kolosov. Alteration of the MEK1/2-ERK1/2 Signaling Pathway in the Retina Associated with Age and Development of AMD-Like Retinopathy. Biochemistry. Biokhimiia. vol 88. issue 2. 2023-04-18. PMID:37072329. |
the progression of the amd-like pathology was also associated with the erk1/2-dependent tau protein hyperphosphorylation and increase in the erk1/2-dependent phosphorylation of alpha b crystallin at ser45 in the retina. |
2023-04-18 |
2023-08-14 |
rat |
| Neel H Mehta, Richard A Suss, Jonathan P Dyke, Neil D Theise, Gloria C Chiang, Sara Strauss, Leslie Saint-Louis, Yi Li, Silky Pahlajani, Vivek Babaria, Lidia Glodzik, Roxana O Carare, Mony J de Leo. Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. Neurobiology of disease. 2022-06-01. PMID:35643187. |
the ability of csf to clear normal and pathological proteins, such as amyloid-beta (aβ), tau, alpha synuclein and others, implicates it production, circulation, and composition, in many neuropathologies. |
2022-06-01 |
2023-08-13 |
human |
| Staci Meredith Weiss, Peter J Marshal. Anticipation across modalities in children and adults: Relating anticipatory alpha rhythm lateralization, reaction time, and executive function. Developmental science. 2022-05-26. PMID:35616474. |
significant anticipatory lateralization was evident for visual and sensorimotor alpha rhythms, but not for tau rhythm modulation in anticipation of an auditory stimulus. |
2022-05-26 |
2023-08-13 |
Not clear |
| David J Brook. Future Imaging in Dementia. Seminars in nuclear medicine. vol 51. issue 3. 2021-12-02. PMID:33353722. |
other medical unmet needs include the need for specific imaging markers of (1) linear tau tangles, tdp-43 and alpha synuclein aggregates; (2) microglial phenotypes that throw light on the activity of these inflammatory cells; (3) activity of intracellular processes which normally act to clear misfolded proteins; (4) epigenetic activity which regulates gene expression. |
2021-12-02 |
2023-08-13 |
Not clear |
| Aruna Sharma, Dafin F Muresanu, Rudy J Castellani, Ala Nozari, José Vicente Lafuente, Seaab Sahib, Z Ryan Tian, Anca D Buzoianu, Ranjana Patnaik, Lars Wiklund, Hari Shanker Sharm. Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO Progress in brain research. vol 258. 2021-11-24. PMID:33223035. |
mild or moderate tbi induces rapid production of tau protein and alpha synuclein (asnc) in the cerebrospinal fluid (csf) and in several brain areas. |
2021-11-24 |
2023-08-13 |
Not clear |
| Aruna Sharma, Dafin F Muresanu, Ranjana Patnaik, Preeti K Menon, Z Ryan Tian, Seaab Sahib, Rudy J Castellani, Ala Nozari, José Vicente Lafuente, Anca D Buzoianu, Stephen D Skaper, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharm. Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy. Progress in brain research. vol 266. 2021-11-24. PMID:34689857. |
pd largely involves dopaminergic pathways with hallmarks of increased alpha synuclein (asnc), and phosphorylated tau (p-tau) in the cerebrospinal fluid (csf) precipitating brain pathology. |
2021-11-24 |
2023-08-13 |
human |
| Nikita van der Vinne, Madelon A Vollebregt, A John Rush, Michiel Eebes, Michel J A M van Putten, Martijn Arn. EEG biomarker informed prescription of antidepressants in MDD: a feasibility trial. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 44. 2021-11-22. PMID:33509659. |
this open-label prospective study assessed the feasibility of using such pre-treatment biomarkers, by using previously identified eeg features (paroxysmal activity; alpha peak frequency; frontal alpha asymmetry) to inform the clinician in selecting among three different antidepressants (ads; escitalopram, sertraline, venlafaxine) as compared to treatment as usual (tau). |
2021-11-22 |
2023-08-13 |
Not clear |
| Keiko Ichinose, Mutsufusa Watanabe, Saneyuki Mizutani, Toru Tanizawa, Toshiki Uchihara, Hiroto Fujigasak. An autopsy case of corticobasal syndrome with pure diffuse Lewy Body Disease. Neurocase. vol 27. issue 3. 2021-10-28. PMID:34128767. |
corticobasal syndrome (cbs) is associated with diverse pathological substrates such as tau, prion protein, transactive response and, rarely, alpha synuclein. |
2021-10-28 |
2023-08-13 |
Not clear |
| Ashley A Edwards, Keanan J Joyner, Christopher Schatschneide. A Simulation Study on the Performance of Different Reliability Estimation Methods. Educational and psychological measurement. vol 81. issue 6. 2021-09-29. PMID:34565817. |
a follow-up regression comparing alpha and omega revealed alpha to be more sensitive to degree of violation of tau equivalence, whereas omega was affected greater by sample size and number of items, especially when population reliability was low. |
2021-09-29 |
2023-08-13 |
Not clear |