| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miyah R Davis, Edward Robinson, Yosef Koronyo, Elena Salobrar-Garcia, Altan Rentsendorj, Bhakta P Gaire, Nazanin Mirzaei, Rakez Kayed, Alfredo A Sadun, Alexander V Ljubimov, Lon S Schneider, Debra Hawes, Keith L Black, Dieu-Trang Fuchs, Maya Koronyo-Hamaou. Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345568. |
retinal ganglion cell vulnerability to pathogenic tau in alzheimer's disease. |
2024-09-30 |
2024-10-02 |
human |
| L Arouche-Delaperche, S Cadoni, C Joffrois, G Labernede, M Valet, Q César, J Dégardin, S Girardon, C Gabriel, S Krantic, S Picau. Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-01-11. PMID:36631898. |
tauopathies, including alzheimer's disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. |
2023-01-11 |
2023-08-14 |
mouse |
| Fan Xia, Yonju Ha, Shuizhen Shi, Yi Li, Shengguo Li, Jonathan Luisi, Rakez Kayed, Massoud Motamedi, Hua Liu, Wenbo Zhan. Early alterations of neurovascular unit in the retina in mouse models of tauopathy. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33762004. |
leukocyte adhesion/infiltration, and microglial recruitment/activation were constantly increased in the retinal ganglion cell layer of tau transgenic mice at different ages, while müller cell gliosis was only detected in relatively older tau mice. |
2021-11-10 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Saranya Canchi, Suhail Rasool, Abderrahman Elmaarouf, Kimberly Thomas, Floyd Sarsoza, Jennifer Grundman, Michael Mante, Jazmin Florio, Nimisha Nandankar, Shaina Korouri, Wagner Zago, Eliezer Masliah, Robert A Rissma. Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2. Neurobiology of disease. vol 152. 2021-08-20. PMID:33516874. |
mutant three-repeat tau expression initiates retinal ganglion cell death through caspase-2. |
2021-08-20 |
2023-08-13 |
mouse |
| Sagnik Sen, Rohit Saxena, Manjari Tripathi, Deepti Vibha, Rebika Dhima. Neurodegeneration in Alzheimer's disease and glaucoma: overlaps and missing links. Eye (London, England). vol 34. issue 9. 2021-06-18. PMID:32152519. |
retinal ganglion cell damage is a characteristic of both diseases, along with discovery of amyloid-β and tau protein deposition in the retina and aqueous humor of eye. |
2021-06-18 |
2023-08-13 |
Not clear |
| Ian F Harrison, Rozalind Whitaker, Pietro Maria Bertelli, James M O'Callaghan, Lajos Csincsik, Martina Bocchetta, Da Ma, Alice Fisher, Zeshan Ahmed, Tracey K Murray, Michael J O'Neill, Jonathan D Rohrer, Mark F Lythgoe, Imre Lengye. Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia. Acta neuropathologica communications. vol 7. issue 1. 2020-04-02. PMID:30616676. |
accumulation of tau and ptau were observed in both the central and peripheral retinal ganglion cell (rgc), inner plexiform and inner nuclear layers of the neurosensory retina of rtg(taup301l)4510 mice. |
2020-04-02 |
2023-08-13 |
mouse |
| Alfonso Grimaldi, Carlo Brighi, Giovanna Peruzzi, Davide Ragozzino, Valentina Bonanni, Cristina Limatola, Giancarlo Ruocco, Silvia Di Angelantoni. Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model. Cell death & disease. vol 9. issue 6. 2019-11-29. PMID:29880901. |
we found the presence of amyloid beta plaques, tau tangles, neurodegeneration, and astrogliosis in the retinal ganglion cell layer of 3xtg-ad mice, already at pre-symptomatic stage. |
2019-11-29 |
2023-08-13 |
mouse |
| Tsz Kin Ng, Jasmine S Y Yung, Kwong Wai Choy, Di Cao, Christopher K S Leung, Herman S Cheung, Chi Pui Pan. Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Scientific reports. vol 5. 2016-09-09. PMID:26549845. |
the differentiated pdlscs demonstrated the characteristics of functional neurons as they expressed neuronal and retinal ganglion cell markers (atoh7, pou4f2, β-iii tubulin, map2, tau, neurod1 and six3), formed synapses and showed glutamate-induced calcium responses as well as spontaneous electrical activities. |
2016-09-09 |
2023-08-13 |
human |
| Natalie D Bull, Alessandra Guidi, Michel Goedert, Keith R Martin, Maria Grazia Spillantin. Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau. PloS one. vol 7. issue 4. 2012-08-23. PMID:22496848. |
reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant p301s tau. |
2012-08-23 |
2023-08-12 |
mouse |
| Aidong Yuan, Asok Kumar, Corrinne Peterhoff, Karen Duff, Ralph A Nixo. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 7. 2008-02-25. PMID:18272688. |
to address this hypothesis, we analyzed the movement of pulse radiolabeled proteins in vivo along retinal ganglion cell (rgc) axons of mice that lack tau or overexpress human tau isoforms. |
2008-02-25 |
2023-08-12 |
mouse |
| Enrico Magnani, Juan Fan, Laura Gasparini, Matthew Golding, Meredith Williams, Giampietro Schiavo, Michel Goedert, Linda A Amos, Maria Grazia Spillantin. Interaction of tau protein with the dynactin complex. The EMBO journal. vol 26. issue 21. 2007-11-30. PMID:17932487. |
mutations of a conserved arginine residue in the n-terminus of tau, found in patients with ftdp-17, affect its binding to dynactin, which is abnormally distributed in the retinal ganglion cell axons of transgenic mice expressing human tau with a mutation in the microtubule-binding domain. |
2007-11-30 |
2023-08-12 |
mouse |
| M Tytell, S T Brady, R J Lase. Axonal transport of a subclass of tau proteins: evidence for the regional differentiation of microtubules in neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 5. 1984-05-02. PMID:6200879. |
this result suggests either that the retinal ganglion cell synthesizes only those two tau proteins or that it synthesizes several of the maps, but commits to axonal transport just two of the tau proteins. |
1984-05-02 |
2023-08-12 |
Not clear |
| M Tytell, S T Brady, R J Lase. Axonal transport of a subclass of tau proteins: evidence for the regional differentiation of microtubules in neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 5. 1984-05-02. PMID:6200879. |
to examine this question, the high molecular weight and tau maps obtained from whole brain preparations of microtubules were compared with the proteins of sca in guinea pig retinal ganglion cell axons by using phosphocellulose chromatography and one- and two-dimensional polyacrylamide gel electrophoresis. |
1984-05-02 |
2023-08-12 |
Not clear |