| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizaveta Mangutov, Yaseen Awad-Igbaria, Kendra Siegersma, Francois Gastambide, Ayodeji A Asuni, Amynah A A Pradha. Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice. The journal of headache and pain. vol 26. issue 1. 2025-04-18. PMID:40251497. |
this study evaluated a novel monoacylglycerol lipase (magl) inhibitor to prolong endocannabinoid action in acute and chronic mouse models of migraine. |
2025-04-18 |
2025-04-21 |
mouse |
| Juanping Wang, Xiaoyu Shi, Junlai Wang, Qiang Zheng, Peipei Shao, Sen Li. Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock. Bioorganic chemistry. vol 159. 2025-03-19. PMID:40107037. |
monoacylglycerol lipase (magl) is an important enzyme for endocannabinoid metabolism by converting 2-arachidonoylglycerol (2-ag) into glycerol and free fatty acids. |
2025-03-19 |
2025-03-22 |
Not clear |
| Anna Pees, Christopher Daniel Morrone, Junchao Tong, Jian Rong, Tuo Shao, Darcy Wear, Steven H Liang, Wai Haung Yu, Neil Vasde. Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [ Theranostics. vol 15. issue 8. 2025-03-17. PMID:40093888. |
we aimed to study changes in cannabinoid receptor 1 (cb1) and monoacylglycerol lipase (magl), components of endocannabinoid signaling and degradation, in a mouse model of ad by pet imaging. |
2025-03-17 |
2025-03-20 |
mouse |
| b' Axel Hentsch, M\\xc3\\xb3nica Guberman, Silke Radetzki, Sofia Kaushik, Mirjam Huizenga, Yingfang He, J\\xc3\\xb6rg Contzen, Bernd Kuhn, J\\xc3\\xb6rg Benz, Maria Schippers, Jerome Paul, Lea Leibrock, Ludovic Collin, Matthias Wittwer, Andreas Topp, Fionn O\\\'Hara, Dominik Heer, Remo Hochstrasser, Julie Blaising, Jens P von Kries, Linjing Mu, Mario van der Stelt, Philipp Mergenthaler, Noa Lipstein, Uwe Grether, Marc Nazar\\xc3\\xa. Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research. Journal of the American Chemical Society. 2025-03-10. PMID:40063733.' |
monoacylglycerol lipase (magl) is the pivotal catabolic enzyme responsible for signal termination in the endocannabinoid system. |
2025-03-10 |
2025-03-13 |
Not clear |
| Marta Kruk-Slomka, Agnieszka Dzik, Grazyna Bial. The Effects of Indirect and Direct Modulation of Endocannabinoid System Function on Anxiety-Related Behavior in Mice Assessed in the Elevated Plus Maze Test. Molecules (Basel, Switzerland). vol 30. issue 4. 2025-02-26. PMID:40005177. |
the ecs, via cannabinoid (cb: cb1 and cb2) receptors, endocannabinoids occurring in the brain (e.g., anandamide (aea) and 2-arachidonoylglycerol (2-ag)) and enzymes degrading endocannabinoids in the brain (fatty-acid amide hydrolase (faah) and monoacylglycerol lipase (magl)), plays a key role in the regulation of mood and anxiety. |
2025-02-26 |
2025-02-28 |
mouse |
| b' Axel Hentsch, M\\xc3\\xb3nica Guberman, Silke Radetzki, Sofia Kaushik, Mirjam Huizenga, Jerome Paul, Maria Schippers, J\\xc3\\xb6rg Benz, Bernd Kuhn, Dominik Heer, Andreas Topp, Ludivine Esteves Gloria, Alexander Walter, Remo Hochstrasser, Matthias B Wittwer, Jens Peter von Kries, Ludovic Collin, Julie Blaising, Mario van der Stelt, Noa Lipstein, Uwe Grether, Marc Nazar\\xc3\\xa. A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase. Angewandte Chemie (International ed. in English). 2025-02-07. PMID:39916545.' |
monoacylglycerol lipase (magl) is a key enzyme for signal termination in the endocannabinoid system (ecs). |
2025-02-07 |
2025-02-09 |
Not clear |
| Qiang Zhang, Chenyu Zhang, Yuanzheng Lu, Haohong Zhan, Bo Li, Hongyan Wei, Yilin Yang, Liaoxing Liao, Chao Lan, Chunlin H. JZL-184 Alleviate Neurological Impairment through Regulation of Mitochondrial Transfer and Lipid Droplet Accumulation after Cardiac Arrest. Molecular neurobiology. 2024-12-24. PMID:39718743. |
jzl-184 is a selective irreversible inhibitor of monoacylglycerol lipase (magl), and previous investigations revealed that jzl-184 confers neuroprotection in the brain following stroke. |
2024-12-24 |
2024-12-26 |
Not clear |
| Yingfang He, MingQiang Zheng, Jiwei Gu, Lisa Reichert, Johannes Trimborn, Hui Zhang, Claudia Keller, Mallory Crosby, Ludovic Collin, Dominik Heer, Anto Pavlovic, Andreas Topp, Matthias Beat Wittwer, Uwe Grether, Luca Gobbi, Roger Schibli, Yiyun Huang, Linjing M. Exploration of (R)-[ European journal of nuclear medicine and molecular imaging. 2024-12-14. PMID:39673602. |
exploration of (r)-[ the monoacylglycerol lipase (magl) plays a pivotal role in modulating the endocannabinoid system and is considered an attractive therapeutic target for diseases in both the central nervous system and periphery. |
2024-12-14 |
2024-12-21 |
Not clear |
| Arlene Martínez-Rivera, Robert N Fetcho, Lizzie Birmingham, Jin Xu, Ruirong Yang, Careen Foord, Diego Scala-Chávez, Narmin Mekawy, Kristen Pleil, Virginia M Pickel, Conor Liston, Carlos M Castorena, Joshua Levitz, Ying-Xian Pan, Lisa A Briand, Anjali M Rajadhyaksha, Francis S Le. Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. Science advances. vol 10. issue 48. 2024-11-29. PMID:39612328. |
here, we show in male and female mice that enhancing levels of the ecb, 2-arachidonoylglycerol (2-ag), through pharmacological inhibition of its catabolic enzyme, monoacylglycerol lipase (magl), either systemically or in the ventral tegmental area (vta) with jzl184, leads to a substantial attenuation of the rewarding effects of opioids in mice using conditioned place preference and self-administration paradigms, without altering their analgesic properties. |
2024-11-29 |
2024-12-02 |
mouse |
| Shivani Jaiswal, Senthil Raja Ayyanna. Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold. Mini reviews in medicinal chemistry. 2024-11-26. PMID:39592899. |
we discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), and α/β-hydrolase domain-containing 6 (abhd6). |
2024-11-26 |
2024-11-29 |
Not clear |
| Naoto Arimura, Chie Maeda, Kazunobu Aoyama, Namiko Yamaguchi, Ayumu Sugiura, Yasuko Takahashi, Ryouta Maeda, Tatsuya Ando, Makoto Kamata, Hideki Matsui, Maiko Tanak. Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration. PloS one. vol 19. issue 11. 2024-11-21. PMID:39570850. |
monoacylglycerol lipase (magl) is involved in neuroinflammation in the brain via the degradation of endocannabinoid 2-arachidonoylglycerol to arachidonic acid, a precursor of some eicosanoids; therefore, magl inhibitors are expected to have anti-inflammatory effects. |
2024-11-21 |
2024-11-24 |
mouse |
| Ning Yang, Meng Li, Xuefeng Li, Lunan Wu, Wenzhi Wang, Yaozeng Xu, Zhen Wang, Chen Zhu, Dechun Gen. MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-10-05. PMID:39368012. |
blocking monoacylglycerol lipase (magl) could effectively ameliorate onfh by mitigating oxidative stress and apoptosis in bmscs induced by glucocorticoids (gc). |
2024-10-05 |
2024-10-08 |
rat |
| Leejeong Kim, Guanghai Nan, Hee Young Kim, Myeounghoon Cha, Bae Hwan Le. Modulation of chemotherapy-induced peripheral neuropathy by JZL195 through glia and the endocannabinoid system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-03. PMID:39362070. |
this study aimed to investigate the effects of jzl195, an inhibitor of fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), and explore the connection between cannabinoid receptors and tlr4 in glial cells. |
2024-10-03 |
2024-10-07 |
mouse |
| Bernd Kuhn, Martin Ritter, Benoit Hornsperger, Charles Bell, Buelent Kocer, Didier Rombach, Marius D R Lutz, Luca Gobbi, Martin Kuratli, Christian Bartelmus, Markus Bürkler, Raffael Koller, Paolo Tosatti, Iris Ruf, Melanie Guerard, Anto Pavlovic, Juliane Stephanus, Fionn O'Hara, Dennis Wetzl, Wiebke Saal, Martine Stihle, Doris Roth, Melanie Hug, Sylwia Huber, Dominik Heer, Carsten Kroll, Andreas Topp, Manfred Schneider, Jürg Gertsch, Sandra Glasmacher, Mario van der Stelt, Andrea Martella, Matthias Beat Wittwer, Ludovic Collin, Jörg Benz, Hans Richter, Uwe Grethe. Structure-Guided Discovery of Journal of medicinal chemistry. 2024-10-03. PMID:39360636. |
structure-guided discovery of monoacylglycerol lipase (magl) is a key enzyme involved in the metabolism of the endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid intimately linked to central nervous system (cns) disorders associated with neuroinflammation. |
2024-10-03 |
2024-10-05 |
Not clear |
| Dexiao Zhu, Jian Zhang, Xiaokuang Ma, Mei Hu, Fei Gao, Jack B Hashem, Jianlu Lyu, Jing Wei, Yuehua Cui, Shenfeng Qiu, Chu Che. Overabundant endocannabinoids in neurons are detrimental to cognitive function. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345517. |
previous studies have demonstrated that inactivating monoacylglycerol lipase (magl), the primary enzyme responsible for degrading 2-ag in the brain, alleviates neuropathology and prevents synaptic and cognitive decline in animal models of neurodegenerative diseases. |
2024-09-30 |
2024-10-02 |
mouse |
| Johannes Aebi, Kenneth Atz, Simon M Ametamey, Jörg Benz, Julie Blaising, Stefania Butini, Giuseppe Campiani, Erick M Carreira, Ludovic Collin, Eva De Lago, Thais Gazzi, Jürg Gertsch, Luca Gobbi, Wolfgang Guba, Javier Fernández-Ruiz, Jürgen Fingerle, Ahmed Haider, Yingfang He, Laura H Heitman, Michael Honer, Daniel Hunziker, Bernd Kuhn, Mauro Maccarrone, Hans Peter Märki, Rainer E Martin, Peter Mohr, Linjing Mu, Marc Nazaré, David F Nippa, Sergio Oddi, Fionn O'Hara, Pal Pacher, Julian Romero, Stephan Röver, Arne C Rufer, Roger Schibli, Gisbert Schneider, Antonia F Stepan, David A Sykes, Christoph Ullmer, Mario Van der Stelt, Dmitry B Veprintsev, Matthias B Wittwer, Uwe Grethe. Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects. Chimia. vol 78. issue 7-8. 2024-09-02. PMID:39221845. |
given its therapeutic significance, we have launched a series of drug discovery endeavors aimed at ecs targets, including peroxisome proliferator-activated receptors (ppars), cannabinoid receptors types 1 (cb1r) and 2 (cb2r), and monoacylglycerol lipase (magl), addressing a wide array of medical needs. |
2024-09-02 |
2024-09-04 |
Not clear |
| Wilmarie Morales-Soto, Beatriz Thomasi, Brian D Gulbranse. Endocannabinoids regulate enteric neuron-glia networks and visceral hypersensitivity following inflammation through a glial-dependent mechanism. Glia. 2024-08-12. PMID:39132860. |
enteric glia modulate gut neurons that control motility and pain and express monoacylglycerol lipase (magl) which controls endocannabinoid availability. |
2024-08-12 |
2024-08-14 |
Not clear |
| Quanwei Yu, Chao Song, Liyun Bi, Shuang Zhao, Qian Lei, Na Yang, Hai Chen, Yuxi Wang, Yang He, Hui Den. Design, synthesis and biological evaluation of naphthyl amide derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorganic & medicinal chemistry. vol 111. 2024-08-06. PMID:39106652. |
monoacylglycerol lipase (magl) is a key enzyme responsible for the metabolism of the endocannabinoid 2-arachidonoylglycerol (2-ag), and has attracted great interest due to its involvement in various physiological and pathological processes, such as cancer progression. |
2024-08-06 |
2024-08-09 |
Not clear |
| Ming Jiang, Mirjam C W Huizenga, Florian Mohr, Avand Amedi, Renze Bakker, Richard J B H N van den Berg, Hui Deng, Tom van der Wel, Constant A A van Boeckel, Mario van der Stel. Structure-Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors. Journal of medicinal chemistry. 2024-07-11. PMID:38988250. |
monoacylglycerol lipase (magl) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-ag). |
2024-07-11 |
2024-07-13 |
Not clear |
| Hongqing Zhao, Yang Liu, Na Cai, Xiaolin Liao, Lin Tang, Yuhong Wan. Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs. Drug design, development and therapy. vol 18. 2024-06-17. PMID:38882045. |
more recent efforts have emphasized that inhibition of two major endogenous cannabinoid hydrolases, monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), indirectly activates cannabinoid receptors by increasing endogenous cannabinoid levels in the synaptic gap, circumventing receptor desensitization resulting from direct enhancement of endogenous cannabinoid signaling. |
2024-06-17 |
2024-06-19 |
Not clear |