| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federica Giona, Stefania Beretta, Antonio Zippo, Alessia Stefanoni, Zaira Tomasoni, Cinzia Vicidomini, Luisa Ponzoni, Mariaelvina Sala, Carrie K Jones, P Jeffrey Conn, Tobias M Boeckers, Carlo Sala, Chiara Verpell. Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome. Molecular psychiatry. 2025-03-16. PMID:40089604. |
moreover, restoring rpl3 expression in the striatum of shank3 ko mice was sufficient to rescue protein synthesis and mitigate excessive grooming, suggesting that the behavioral alterations observed in shank3 ko mice might be, at least in part, caused by rpl3 downregulation and consequent impaired protein synthesis. |
2025-03-16 |
2025-03-18 |
mouse |
| Federica Giona, Stefania Beretta, Antonio Zippo, Alessia Stefanoni, Zaira Tomasoni, Cinzia Vicidomini, Luisa Ponzoni, Mariaelvina Sala, Carrie K Jones, P Jeffrey Conn, Tobias M Boeckers, Carlo Sala, Chiara Verpell. Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome. Molecular psychiatry. 2025-03-16. PMID:40089604. |
in this study, we report that the ribosomal protein rpl3 and overall protein synthesis are downregulated in the cortex and striatum of shank3 knockout (ko) mice and in neurons differentiated from human-induced pluripotent stem cells (hipscs) derived from a pms patient. |
2025-03-16 |
2025-03-18 |
mouse |
| Jing Yang, Guaiguai Ma, Xiaohui Du, Jinyi Xie, Mengmeng Wang, Wenting Wang, Baolin Guo, Shengxi W. Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse. Neuroscience bulletin. 2024-12-18. PMID:39693031. |
utilizing the shank3b knockout (ko) mouse model, we examined shank3 expression and its impact on neuronal maturation through golgi staining for dendritic morphology and electrophysiological recordings to measure synaptic function in the anterior cingulate cortex (acc) across different postnatal stages. |
2024-12-18 |
2024-12-21 |
mouse |
| Caroline Gora, Ana Dudas, Lucas Court, Anil Annamneedi, Gaëlle Lefort, Thiago S Nakahara, Nicolas Azzopardi, Adrien Acquistapace, Anne-Lyse Laine, Anne-Charlotte Trouillet, Lucile Drobecq, Emmanuel Pecnard, Benoît Piégu, Pascale Crépieux, Pablo Chamero, Lucie P Pellissie. Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism. Translational psychiatry. vol 14. issue 1. 2024-11-06. PMID:39505842. |
in this study, we examined how the social environment influences both wild-type (wt) and shank3 knockout (ko) mice, a model reflecting core autism-like traits. |
2024-11-06 |
2024-11-09 |
mouse |
| Caroline Gora, Ana Dudas, Lucas Court, Anil Annamneedi, Gaëlle Lefort, Thiago S Nakahara, Nicolas Azzopardi, Adrien Acquistapace, Anne-Lyse Laine, Anne-Charlotte Trouillet, Lucile Drobecq, Emmanuel Pecnard, Benoît Piégu, Pascale Crépieux, Pablo Chamero, Lucie P Pellissie. Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism. Translational psychiatry. vol 14. issue 1. 2024-11-06. PMID:39505842. |
conversely, an enriched social environment heightened social interest toward novel conspecifics in wt mice, but elicited the opposite effect in shank3 ko mice. |
2024-11-06 |
2024-11-09 |
mouse |
| Caroline Gora, Ana Dudas, Lucas Court, Anil Annamneedi, Gaëlle Lefort, Thiago S Nakahara, Nicolas Azzopardi, Adrien Acquistapace, Anne-Lyse Laine, Anne-Charlotte Trouillet, Lucile Drobecq, Emmanuel Pecnard, Benoît Piégu, Pascale Crépieux, Pablo Chamero, Lucie P Pellissie. Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism. Translational psychiatry. vol 14. issue 1. 2024-11-06. PMID:39505842. |
furthermore, it restored impairments in social novelty preference and olfactory function, as well as self-grooming in shank3 ko mice. |
2024-11-06 |
2024-11-09 |
mouse |
| Wisam Bazbaz, Maryam Kartawy, Wajeha Hamoudi, Shashank Kumar Ojha, Igor Khaliulin, Haitham Ama. The Role of Thioredoxin System in Shank3 Mouse Model of Autism. Journal of molecular neuroscience : MN. vol 74. issue 4. 2024-09-30. PMID:39347996. |
we hypothesize that the trx system is altered in the shank3 ko mouse model of autism, which may lead to a decreased activity of the nuclear factor erythroid 2-related factor 2 (nrf2), resulting in oxidative stress, and thus, contributing to asd-related phenotypes. |
2024-09-30 |
2024-10-02 |
mouse |
| Tianhua Wang, Yunxia Bai, Xianjie Zheng, Xinxia Liu, Shuang Xing, Linbin Wang, Huimin Wang, Guoping Feng, Chunxia L. Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-04-03. PMID:35368073. |
here, we report that sapap4 knockout (ko) mice have reduced spine density in the prefrontal cortex and abnormal compositions of key postsynaptic proteins in the postsynaptic density (psd) including reduced psd95, glur1, and glur2 as well as increased shank3. |
2022-04-03 |
2023-08-13 |
mouse |
| Gonzalo H Otazu, Yan Li, Zachary Lodato, Adel Elnasher, Katherine M Keever, Ying Li, Raddy L Ramo. Neurodevelopmental malformations of the cerebellum and neocortex in the Shank3 and Cntnap2 mouse models of autism. Neuroscience letters. vol 765. 2021-11-08. PMID:34555490. |
in the present report, we document the presence of cerebellar and neocortical heterotopia in heterozygous and ko shank3 and cntnap2 mice which are due to the c57bl/6 genotype and discuss the role these malformations may play in research using these genetic models of autism. |
2021-11-08 |
2023-08-13 |
mouse |
| Morgane Chiesa, Romain Nardou, Natalia Lozovaya, Sanaz Eftekhari, Roman Tyzio, Damien Guimond, Diana C Ferrari, Yehezkel Ben-Ar. Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice. Neural plasticity. vol 2019. 2020-07-27. PMID:31354805. |
enhanced glutamatergic currents at birth in shank3 ko mice. |
2020-07-27 |
2023-08-13 |
mouse |
| Chunmei Jin, Shinhyun Kim, Hyojin Kang, Ki Na Yun, Yeunkum Lee, Yinhua Zhang, Yoonhee Kim, Jin Young Kim, Kihoon Ha. Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63-linked polyubiquitin chains. Journal of neurochemistry. vol 150. issue 6. 2020-03-23. PMID:31215654. |
by comparing these proteins with those found in a previous analysis of the postsynaptic density of shank3 knock-out (ko) striatum, we identified and confirmed that cylindromatosis-associated deubiquitinase (cyld), a deubiquitinase specific for lys63-linked polyubiquitin chains, was up- and down-regulated in shank3 tg and ko striatal synapses, respectively. |
2020-03-23 |
2023-08-13 |
mouse |
| Laure Tabouy, Dimitry Getselter, Oren Ziv, Marcela Karpuj, Timothée Tabouy, Iva Lukic, Rasha Maayouf, Nir Werbner, Hila Ben-Amram, Meital Nuriel-Ohayon, Omry Koren, Evan Elliot. Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29787855. |
l. reuteri, a species with decreased relative abundance in the shank3 ko mice, positively correlated with the expression of gamma-aminobutyric acid (gaba) receptor subunits in the brain. |
2019-08-06 |
2023-08-13 |
mouse |
| Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Shunan Liu, Craig M Powel. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism research : official journal of the International Society for Autism Research. vol 9. issue 3. 2017-01-11. PMID:26559786. |
both shank3(e4-9) het and ko demonstrated a significant reduction in nmda/ampa ratio at excitatory synapses onto striatal medium spiny neurons. |
2017-01-11 |
2023-08-13 |
mouse |
| Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Shunan Liu, Craig M Powel. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism research : official journal of the International Society for Autism Research. vol 9. issue 3. 2017-01-11. PMID:26559786. |
behaviorally, both shank3(e4-9) heterozygous (het) and shank3(e4-9) ko mice display increased repetitive grooming, deficits in novel and spatial object recognition learning and memory, and abnormal ultrasonic vocalizations. |
2017-01-11 |
2023-08-13 |
mouse |
| Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Shunan Liu, Craig M Powel. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism research : official journal of the International Society for Autism Research. vol 9. issue 3. 2017-01-11. PMID:26559786. |
furthermore, shank3(e4-9) ko mice displayed reduced hippocampal ltp despite normal baseline synaptic transmission. |
2017-01-11 |
2023-08-13 |
mouse |