| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byumseok Koh, Young Eun Kim, Sung Bum Park, Seong Soon Kim, Jangjae Lee, Jeong Hyeon Jo, KyungJin Lee, Dong Hyuck Bae, Tae-Young Kim, Sung-Hee Cho, Myung Ae Bae, Dukjin Kang, Ki Young Ki. Unraveling the Molecular Landscape of SCN1A Gene Knockout in Cerebral Organoids: A Multiomics Approach Utilizing Proteomics, Lipidomics, and Transcriptomics. ACS omega. vol 9. issue 38. 2024-09-30. PMID:39346820. |
this study investigates the impact of sodium channel protein type 1 subunit alpha (scn1a) gene knockout (scn1a ko) on brain development and function using cerebral organoids coupled with a multiomics approach. |
2024-09-30 |
2024-10-02 |
Not clear |
| Byumseok Koh, Young Eun Kim, Sung Bum Park, Seong Soon Kim, Jangjae Lee, Jeong Hyeon Jo, KyungJin Lee, Dong Hyuck Bae, Tae-Young Kim, Sung-Hee Cho, Myung Ae Bae, Dukjin Kang, Ki Young Ki. Unraveling the Molecular Landscape of SCN1A Gene Knockout in Cerebral Organoids: A Multiomics Approach Utilizing Proteomics, Lipidomics, and Transcriptomics. ACS omega. vol 9. issue 38. 2024-09-30. PMID:39346820. |
from comprehensive omics analyses, we found that scn1a ko organoids exhibit decreased growth, dysregulated neurotransmitter levels, and altered lipidomic, proteomic, and transcriptomic profiles compared to controls under matrix-free differentiation conditions. |
2024-09-30 |
2024-10-02 |
Not clear |
| Kay Richards, Nikola Jancovski, Eric Hanssen, Alan Connelly, Steve Petro. Atypical myelinogenesis and reduced axon caliber in the Scn1a variant model of Dravet syndrome: An electron microscopy pilot study of the developing and mature mouse corpus callosum. Brain research. vol 1751. 2021-11-30. PMID:33069731. |
morphometric analyses of axons within the corpus callosum were completed at p16 and p50 in scn1a heterozygote ko male mice and their age-matched wild-type littermates. |
2021-11-30 |
2023-08-13 |
mouse |
| Kay Richards, Nikola Jancovski, Eric Hanssen, Alan Connelly, Steve Petro. Atypical myelinogenesis and reduced axon caliber in the Scn1a variant model of Dravet syndrome: An electron microscopy pilot study of the developing and mature mouse corpus callosum. Brain research. vol 1751. 2021-11-30. PMID:33069731. |
the data has indicated, in the absence of behavioral seizures, factors that governed a shift toward small calibre axons at p16 have persisted in adult scn1a heterozygote ko corpus callosum. |
2021-11-30 |
2023-08-13 |
mouse |
| Sung Han, Frank H Yu, Michael D Schwartz, Jonathan D Linton, Martha M Bosma, James B Hurley, William A Catterall, Horacio O de la Iglesi. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 6. 2012-03-30. PMID:22223655. |
electrical stimulation of the optic chiasm elicits reduced calcium transients and impaired ventro-dorsal communication in scn neurons from scn1a(+/-) mice, and this communication is barely detectable in the homozygous gene ko (scn1a(-/-)). |
2012-03-30 |
2023-08-12 |
mouse |