| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sor. Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural pharmacology. 2023-09-05. PMID:37668157. |
to clarify the action of meth in 5-ht1b ko mice the effects of meth on extracellular levels of da (daec) and 5-ht (5-htec) in the caudate putamen (cpu) and the nucleus accumbens (nac) were examined. |
2023-09-05 |
2023-09-07 |
mouse |
| Katrina Y Choe, Richard A I Bethlehem, Martin Safrin, Hongmei Dong, Elena Salman, Ying Li, Valery Grinevich, Peyman Golshani, Laura A DeNardo, Olga Peñagarikano, Neil G Harris, Daniel H Geschwin. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. Neuron. 2021-12-21. PMID:34932941. |
our findings establish circuit- and systems-level mechanisms of social deficits in cntnap2 ko mice and reveal the nac as a region that can be modulated by oxytocin to promote social interactions. |
2021-12-21 |
2023-08-13 |
mouse |
| Yun-Fang Jia, Chelsea A Vadnie, Ada Man-Choi Ho, Lee Peyton, Marin Veldic, Katheryn Wininger, Aleksey Matveyenko, Doo-Sup Cho. Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31267611. |
furthermore, viral-mediated rescue of ent1 expression in the nac of ent1 ko mice reduced ethanol drinking, demonstrating a possible causal link between ent1 expression and ethanol drinking in males. |
2021-08-11 |
2023-08-13 |
mouse |
| Gang Lei, Fei Liu, Peng Liu, Tong Jiao, Liu Yang, Zheng Chu, Li-Sha Deng, Yan Li, Yong-Hui Dan. Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors? Schizophrenia research. vol 222. 2021-06-17. PMID:32439293. |
total glutamate was decreased in the medial prefrontal cortex, nucleus accumbens (nac), and hip of ko mice. |
2021-06-17 |
2023-08-13 |
mouse |
| Kuisheng Sun, Feng Wang, Lin Ma, Xiaofan Ren, Chun Zhang, Weifang Rong, Tao Su. Genetic knockout of the G protein-coupled estrogen receptor 1 facilitates the acquisition of morphine-induced conditioned place preference and aversion in mice. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32184017. |
our study used gper1 knockout (gper1 ko) and wild-type (wt) mice to compare the sensitivity differences of morphine- and sucrose-induced conditioned place preference (cpp) and naloxone-induced conditioned place aversion (cpa), and differences in dopamine (da) content in the nucleus accumbens (nac) were determined by high performance liquid chromatography (hplc). |
2020-12-28 |
2023-08-13 |
mouse |
| Francisco J Pavón, Antonia Serrano, David G Stouffer, Ilham Polis, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parson. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30421483. |
extracellular levels of endocannabinoids and relevant neurotransmitters were measured by in vivo microdialysis in the nucleus accumbens (nac) of faah knockout (ko) and wild-type (wt) mice during an ethanol (etoh; 2 g/kg, ip) challenge in etoh-naive and repeated (r) etoh-treated mice. |
2020-10-28 |
2023-08-13 |
mouse |
| Eri Takeuchi, Daisuke Yamada, Satoshi Suzuki, Akiyoshi Saitoh, Masayuki Itoh, Takashi Hayashi, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguch. Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids. PloS one. vol 15. issue 3. 2020-06-29. PMID:32210469. |
a dopamine metabolite, 3,4-dihydroxyphenylacetic acid, increased in the nac in male mice fed the ko diet when compared with those fed the control diet. |
2020-06-29 |
2023-08-13 |
mouse |
| Eri Takeuchi, Daisuke Yamada, Satoshi Suzuki, Akiyoshi Saitoh, Masayuki Itoh, Takashi Hayashi, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguch. Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids. PloS one. vol 15. issue 3. 2020-06-29. PMID:32210469. |
in addition, dopamine, 3-methoxytyramine, and homovanillic acid increased in the nac in female mice fed the ko diet. |
2020-06-29 |
2023-08-13 |
mouse |
| Eri Takeuchi, Daisuke Yamada, Satoshi Suzuki, Akiyoshi Saitoh, Masayuki Itoh, Takashi Hayashi, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguch. Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids. PloS one. vol 15. issue 3. 2020-06-29. PMID:32210469. |
notably, the effects of the ko diet on the immobility time in the fst were abolished by microinjection of sulpiride, an antagonist of d2-like receptors, into the nac. |
2020-06-29 |
2023-08-13 |
mouse |
| Rick E Bernardi, Anastasia Olevska, Ilaria Morella, Stefania Fasano, Eugenio Santos, Riccardo Brambilla, Rainer Spanage. The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 32. 2020-06-25. PMID:31182637. |
interestingly, the lentiviral knockdown of rasgrf2 in the nac had the opposite effect to that in rasgrf2 ko mice, reducing cocaine sa. |
2020-06-25 |
2023-08-13 |
mouse |
| Rick E Bernardi, Anastasia Olevska, Ilaria Morella, Stefania Fasano, Eugenio Santos, Riccardo Brambilla, Rainer Spanage. The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 32. 2020-06-25. PMID:31182637. |
we subsequently demonstrated that the mek inhibitor pd325901 administered peripherally prior to cocaine sa increased cocaine intake, replicating the increase seen in rasgrf2 ko mice, whereas pd325901 administered into the nac decreased cocaine intake, similar to the effect seen following lentiviral knockdown of rasgrf2. |
2020-06-25 |
2023-08-13 |
mouse |
| Dachun Xu, Yifan Zhao, Xinyu Weng, Yuyan Lu, Weiming Li, Kai Tang, Wei Chen, Zheng Liu, Xinrui Qi, Jialing Zheng, John Fassett, Yi Zhang, Yawei X. Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy. Journal of molecular and cellular cardiology. vol 128. 2020-06-18. PMID:30707992. |
importantly, dampening oxidative stress with n-acetylcysteine (nac) lowered hypertrophy in mtg1 ko to wt levels. |
2020-06-18 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
we conducted a microdialysis study to characterize nicotine-induced changes in da and serotonin (5-ht) levels in the nac of faah knockout (ko) mice using a conditioned place preference-like paradigm with three nicotine doses (0.1, 1 and 10 mg/kg, s.c.). |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
furthermore, faah ko mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.05), with no differences between the genotypes at higher doses. |
2019-09-17 |
2023-08-13 |
mouse |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
similar to faah ko mice, pf-3845-pretreated mice displayed a moderate enhancement of the effect of low-dose nicotine on nac 5-ht release (p < 0.01). |
2019-09-17 |
2023-08-13 |
mouse |
| Kazuhito Nakao, Vivek Jeevakumar, Sunny Zhihong Jiang, Yuko Fujita, Noelia B Diaz, Carlos A Pretell Annan, Karen L Eskow Jaunarajs, Kenji Hashimoto, Juan E Belforte, Kazu Nakazaw. Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction. Schizophrenia bulletin. vol 45. issue 1. 2019-06-19. PMID:29394409. |
here, we report enhanced dopaminomimetic-induced locomotor activity in these mutants, along with bidirectional, site-specific changes in in vivo amphetamine-induced dopamine release: nucleus accumbens (nac) dopamine release was enhanced by amphetamine in postnatal ppp1r2-cre/grin1 knockout (ko) mice, whereas dopamine release was dramatically reduced in the medial pfc (mpfc) compared to controls. |
2019-06-19 |
2023-08-13 |
mouse |
| Samantha Mancino, Sueli Mendonça-Netto, Elena Martín-García, Rafael Maldonad. Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour. Addiction biology. vol 22. issue 5. 2018-05-16. PMID:27101941. |
for this purpose, we evaluated the specific role of this receptor in the behavioural and neuroplastic changes induced by palatable food in the prefrontal cortex (pfc), hippocampus (hcp) and nucleus accumbens (nac) in constitutive knockout (ko) mice deficient in dor. |
2018-05-16 |
2023-08-13 |
mouse |
| Samantha Mancino, Sueli Mendonça-Netto, Elena Martín-García, Rafael Maldonad. Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour. Addiction biology. vol 22. issue 5. 2018-05-16. PMID:27101941. |
this operant training to obtain palatable food increased dendritic spine density in the pfc, hcp and nac shell of wild-type, but these plasticity changes were abolished in dor ko mice. |
2018-05-16 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
furthermore, ko mice showed increased brain-derived neurotrophic factor (bdnf) and its receptor trkb signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (nac), although bdnf-trkb signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus. |
2018-05-14 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
systemic administration of the trkb antagonist ana-12, but not the trkb agonist 7,8-dihydroxyflavone and the selective serotonin reuptake inhibitor fluoxetine, showed a rapid antidepressant effect in ko mice by normalizing increased synaptogenesis in the nac. |
2018-05-14 |
2023-08-13 |
mouse |