| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Yao, Jingyi Du, Dongshuang Wang, Naigang Li, Zhouhang Tao, Dong Wu, Fan Peng, Jiaming Shi, Wenjuan Zhou, Tiantian Zhao, Yuchun Tan. High-intensity interval training ameliorates postnatal immune activation-induced mood disorders through KDM6B-regulated glial activation. Brain, behavior, and immunity. 2024-06-08. PMID:38851307. |
rna-seq of prefrontal cortex (pfc) tissues revealed a gene expression pattern, confirming that hiit was more effective than mict in improving brain glial cell activation through epigenetic modifications of kdm6b. |
2024-06-08 |
2024-06-11 |
mouse |
| Samara Vilca, Claes Wahlestedt, Sari Izenwasser, Raul R Gainetdinov, Marta Pard. Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509143. |
(2) methods: dat transgenic rats were treated chronically with cocaine (10 mg/kg) for 8 days, and the expression of epigenetic modulators, lysine demethylase 6b (kdm6b) and bromodomain-containing protein 4 (brd4), was examined in the prefrontal cortex (pfc). |
2023-07-29 |
2023-08-14 |
rat |
| Andrea L Johnstone, Nadja S Andrade, Estelle Barbier, Bohdan B Khomtchouk, Christopher A Rienas, Kenneth Lowe, Derek J Van Booven, Esi Domi, Rustam Esanov, Samara Vilca, Jenica D Tapocik, Keli Rodriguez, Danielle Maryanski, Michael Christopher Keogh, Marcus W Meinhardt, Wolfgang H Sommer, Markus Heilig, Zane Zeier, Claes Wahlested. Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. Addiction biology. vol 26. issue 1. 2021-09-09. PMID:31373129. |
follow-up studies of one of these enzymes, the histone demethylase kdm6b, showed that this enzyme exhibits region-specific dysregulation in the prefrontal cortex and nucleus accumbens of alcohol-dependent rats. |
2021-09-09 |
2023-08-13 |
human |
| Yangping Shentu, Qiuyun Tian, Jinge Yang, Xiaoyuan Liu, Yujiao Han, Dichen Yang, Nan Zhang, Xiaofang Fan, Ping Wang, Jianshe Ma, Ran Chen, Dantong Li, Shouting Liu, Yongyu Wang, Sunzhong Mao, Yongsheng Gong, Congkuo Du, Junming Fa. Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33865886. |
we found that kdm6b, vgll4, interleukin-1β (il-1β), and ionized calcium-binding adaptor molecule-1 (iba-1, microglia marker) protein levels were increased in lps-dose dependent manner in the hippocampus but not in prefrontal cortex. |
2021-09-02 |
2023-08-13 |
mouse |