| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bastian Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo C Meza, Nicolas Merino-Veliz, Gino Nardocci, Lorena Varela-Nallar, Gloria Arriagada, Andrés E Chávez, Fernando J Busto. Impact of KDM6B mosaic brain knockout on synaptic function and behavior. Scientific reports. vol 14. issue 1. 2024-09-02. PMID:39223259. |
moreover, kdm6b mosaic knockout display abnormalities in hippocampal excitatory synaptic transmission decreasing nmda receptor mediated synaptic transmission and plasticity. |
2024-09-02 |
2024-09-05 |
Not clear |
| Yanan Wang, Nitin Khandelwal, Shuiqiao Liu, Mi Zhou, Lei Bao, Jennifer E Wang, Ashwani Kumar, Chao Xing, Jay R Gibson, Yingfei Wan. KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2. Molecular psychiatry. 2022-08-26. PMID:36028572. |
here, we showed that lysine demethylase kdm6b was expressed in excitatory neurons and declined in hippocampus with age. |
2022-08-26 |
2023-08-14 |
mouse |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
we also found that mi decreased kdm6b while increased sirt1 expression in the hippocampus of mi rats relative to those in controls. |
2021-10-29 |
2023-08-13 |
rat |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
together, these results suggest a potential role of hippocampal epigenetic signaling in mi-induced anxiety-like behavior in rats, and pharmacological targeting kdm6b or sirt1 could be a strategy to ameliorate anxiety-like behavior induced by mi. |
2021-10-29 |
2023-08-13 |
rat |
| Yangping Shentu, Qiuyun Tian, Jinge Yang, Xiaoyuan Liu, Yujiao Han, Dichen Yang, Nan Zhang, Xiaofang Fan, Ping Wang, Jianshe Ma, Ran Chen, Dantong Li, Shouting Liu, Yongyu Wang, Sunzhong Mao, Yongsheng Gong, Congkuo Du, Junming Fa. Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33865886. |
we found that kdm6b, vgll4, interleukin-1β (il-1β), and ionized calcium-binding adaptor molecule-1 (iba-1, microglia marker) protein levels were increased in lps-dose dependent manner in the hippocampus but not in prefrontal cortex. |
2021-09-02 |
2023-08-13 |
mouse |
| Yangping Shentu, Qiuyun Tian, Jinge Yang, Xiaoyuan Liu, Yujiao Han, Dichen Yang, Nan Zhang, Xiaofang Fan, Ping Wang, Jianshe Ma, Ran Chen, Dantong Li, Shouting Liu, Yongyu Wang, Sunzhong Mao, Yongsheng Gong, Congkuo Du, Junming Fa. Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33865886. |
collectively, these results demonstrate that the induction of neuroinflammation by lps promotes kdm6b activation in the hippocampus, and lps-induced anxiety-like behavior is associated with upregulation of vgll4 by kdm6b in the hippocampus. |
2021-09-02 |
2023-08-13 |
mouse |
| Andrea S Link, Svitlana Kurinna, Steven Havlicek, Sandra Lehnert, Martin Reichel, Johannes Kornhuber, Beate Winner, Tobias Huth, Fang Zheng, Sabine Werner, Christian Alzheime. Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling. Molecular neurobiology. vol 53. issue 6. 2018-01-15. PMID:26215835. |
chromatin immunoprecipitation experiments with hippocampal lysates subsequently revealed that binding of smad2/3, the intracellular effectors of activin signaling, was significantly enriched at the pmepa1 gene, which encodes a negative feedback regulator of tgf-β signaling in cancer cells, and at the kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. |
2018-01-15 |
2023-08-13 |
mouse |
| Ranjula Wijayatunge, Liang-Fu Chen, Young May Cha, Anthony S Zannas, Christopher L Frank, Anne E Wes. The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24983519. |
pilocarpine drove a 20-fold increase in mrna encoding the histone h3 lysine 27-specific demethylase kdm6b selectively in granule neurons of the dentate gyrus, and this induction was recapitulated in cultured hippocampal neurons by bicuculline and 4-aminopyridine (bic + 4ap) stimulation of synaptic activity. |
2015-04-15 |
2023-08-13 |
mouse |
| Ranjula Wijayatunge, Liang-Fu Chen, Young May Cha, Anthony S Zannas, Christopher L Frank, Anne E Wes. The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24983519. |
the histone lysine demethylase kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. |
2015-04-15 |
2023-08-13 |
mouse |