| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Alcoverro, I Schofield, S Spinillo, A Tauro, M Ruggeri, M Lowrie, S A Gome. Thoracolumbar hydrated nucleus pulposus extrusion and intervertebral disc extrusion in dogs: comparison of clinical presentation and magnetic resonance imaging findings. Veterinary journal (London, England : 1997). 2024-06-21. PMID:38906413. |
the mri features of the affected ivd space, herniated ivd material, affected overlying spinal cord and local epaxial musculature were evaluated for each group. |
2024-06-21 |
2024-06-24 |
Not clear |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
this study used an in vivo rat annulus fibrosus (af) injury-driven discogenic pain model to investigate the acute and chronic changes in ivd degeneration and spinal inflammation, as well as sensitization, inflammation, and remodeling in dorsal root ganglion (drg) and spinal cord (sc) dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
ep injury increased cd68 macrophages in the ep and vertebrae, and spinal cord subp-, iba1- and gfap-ir were positively correlated with ivd degeneration and cd68-ir ep and vertebrae. |
2023-02-25 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
lack of effective disease-modifying treatments for ivds with endplate (ep) defects means there is a need for an animal model to improve understanding of how ep-driven ivd degeneration can lead to spinal cord sensitization. |
2023-02-25 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
we conclude that ep injuries result in broad spinal inflammation with crosstalk between spinal cord, vertebrae and ivd, suggesting that therapies must address neural pathologies, ivd degeneration, and chronic spinal inflammation. |
2023-02-25 |
2023-08-14 |
rat |
| Adrien Robin, Nastassia Navasiolava, Guillemette Gauquelin-Koch, Claude Gharib, Marc-Antoine Custaud, Loïc Treffe. Spinal changes after 5-day dry immersion as shown by magnetic resonance imaging (DI-5-CUFFS). American journal of physiology. Regulatory, integrative and comparative physiology. 2022-06-14. PMID:35700204. |
intervertebral disc (ivd) height, spinal cord position, and apparent diffusion coefficient (adc; reflecting global water motion) were measured using magnetic resonance imaging before and after di. |
2022-06-14 |
2023-08-14 |
Not clear |
| Meletios Liaskos, Michalis A Savelonas, Pantelis A Asvestas, Dimitrios Papageorgiou, George K Matsopoulo. Vertebrae, IVD and spinal canal boundary extraction on MRI, utilizing CT-trained active shape models. International journal of computer assisted radiology and surgery. vol 16. issue 12. 2021-11-29. PMID:34643884. |
vertebrae, intervertebral disc (ivd) and spinal canal (sc) displacements are in the root of several spinal cord pathologies. |
2021-11-29 |
2023-08-13 |
Not clear |
| Marie-Hélène Beauséjour, Eric Wagnac, Pierre-Jean Arnoux, Jean-Marc Mac Thiong, Yvan Peti. Numerical Investigation of Spinal Cord Injury After Flexion-Distraction Injuries at the Cervical Spine. Journal of biomechanical engineering. vol 144. issue 1. 2021-09-22. PMID:34369552. |
in flexion, complete ivd rupture combined with posterior ligamentous complex rupture was the most severe injury leading to the highest von mises stress (47-66 kpa), principal strains p1 (0.32-0.41 in white matter) and p3 (-0.78 to -0.96 in white matter) in the spinal cord and the highest spinal cord compression (35-48%). |
2021-09-22 |
2023-08-13 |
Not clear |
| Marie-Hélène Beauséjour, Eric Wagnac, Pierre-Jean Arnoux, Jean-Marc Mac Thiong, Yvan Peti. Numerical Investigation of Spinal Cord Injury After Flexion-Distraction Injuries at the Cervical Spine. Journal of biomechanical engineering. vol 144. issue 1. 2021-09-22. PMID:34369552. |
a cervical spine finite element model including the spinal cord was used and different combinations of partial or complete intervertebral disc (ivd) rupture and disruption of various posterior ligaments were modeled at c4-c5, c5-c6, or c6-c7. |
2021-09-22 |
2023-08-13 |
Not clear |
| Ali Babashahi, Morteza Taheri, Parham Rabie. Spontaneous Resolution of Symptomatic Thoracic Spine Calcified Disc Herniation: A Case Report and Literature Review. Iranian journal of medical sciences. vol 44. issue 3. 2020-09-30. PMID:31182892. |
the spinal imaging revealed that calcification within ivd, associated with huge calcified disc herniation on the t5/6, resulted in cord compression and syrinx formation within the spinal cord from t4/5 through t9/10. |
2020-09-30 |
2023-08-13 |
Not clear |
| Sophie Bittermann, Christof Schild, Eliane Marti, Jelena Mirkovitch, Daniela Schweizer, Diana Henk. Analysis of blood degradation products and ferritin in the cerebrospinal fluid of dogs with acute thoracolumbar intervertebral disk extrusion, a prospective pilot study. BMC veterinary research. vol 15. issue 1. 2019-07-04. PMID:31088486. |
hemorrhage in the spinal canal leads to further damage of the spinal cord influencing outcome in dogs with intervertebral disk (ivd) extrusion. |
2019-07-04 |
2023-08-13 |
Not clear |
| V A Byval'tsev, A A Kalinin, I A Stepanov, Yu Ya Pestryakov, V V Shepele. [Analysis of the results of total cervical disc arthroplasty using a M6-C prosthesis: a multicenter study]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko. vol 81. issue 5. 2018-04-17. PMID:29076467. |
cervical spondylosis and intervertebral disc (ivd) degeneration are the most common cause for compression of the spinal cord and/or its roots. |
2018-04-17 |
2023-08-13 |
Not clear |
| Diana Henke, Daniela Gorgas, Marcus G Doherr, Judith Howard, Franck Forterre, Marc Vandeveld. Longitudinal extension of myelomalacia by intramedullary and subdural hemorrhage in a canine model of spinal cord injury. The spine journal : official journal of the North American Spine Society. vol 16. issue 1. 2016-08-19. PMID:26386168. |
in canine intervertebral disc (ivd) extrusion, a spontaneous animal model of spinal cord injury, hemorrhage is a consistent finding. |
2016-08-19 |
2023-08-13 |
Not clear |
| Chang-Cheng Liu, Fa-Ming Tian, Zhuang Zhou, Peng Wang, Yu Gou, Heng Zhang, Wen-Ya Wang, Yong Shen, Ying-Ze Zhang, Liu Zhan. Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat. BMC musculoskeletal disorders. vol 16. 2016-07-14. PMID:26552386. |
intervertebral disc (ivd) degeneration and pathological changes in the spinal cord are major causes of back pain. |
2016-07-14 |
2023-08-13 |
rat |
| Claire Cunningham, Akshay Srivastava, Estelle Collin, Sibylle Grad, Mauro Alini, Abhay Pandit, J Gerard Wal. Isolation and characterisation of a recombinant antibody fragment that binds NCAM1-expressing intervertebral disc cells. PloS one. vol 8. issue 12. 2014-09-29. PMID:24349544. |
the scfv also labelled cells in bovine spinal cord and six-month and two-year old bovine ivd sections by immunohistochemistry. |
2014-09-29 |
2023-08-12 |
human |
| William Mark Erwi. Biologically based therapy for the intervertebral disk: who is the patient? Global spine journal. vol 3. issue 3. 2014-06-24. PMID:24436870. |
the ivd must tolerate immense loads, protect the spinal cord, and contribute considerable flexibility and strength to the spinal column. |
2014-06-24 |
2023-08-12 |
human |
| D Henke, M Vandevelde, M G Doherr, M Stöckli, F Forterr. Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23702280. |
this retrospective study evaluated the extent to which neurological signs correlated with histologically detected spinal cord damage in 60 dogs that were euthanased because of thoracolumbar ivd herniation. |
2014-06-19 |
2023-08-12 |
Not clear |
| D Henke, M Vandevelde, M G Doherr, M Stöckli, F Forterr. Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23702280. |
the outcome of spinal surgery in dogs with absent voluntary motor function and nociception following intervertebral disc (ivd) herniation is highly variable, which likely attests to differences in the severity of spinal cord damage. |
2014-06-19 |
2023-08-12 |
Not clear |
| Yejia Zhang, James M Kerns, D Greg Anderson, Young Sang Lee, Er-Yun Chen, Chadi Tannoury, Howard S A. Sensory neurons and fibers from multiple spinal cord levels innervate the rabbit lumbar disc. American journal of physical medicine & rehabilitation. vol 85. issue 11. 2006-11-28. PMID:17079958. |
to establish the neurotransmission pathway from the lumbar l5/6 intervertebral disc (ivd) to the spinal cord in the rabbit. |
2006-11-28 |
2023-08-12 |
rabbit |
| Chisa Hidaka, Safdar N Khan, James C Farmer, Harvinder S Sandh. Gene therapy for spinal applications. The Orthopedic clinics of North America. vol 33. issue 2. 2002-11-06. PMID:12389290. |
finally, the high throughput technologies, such as the gene chip, are elucidating thousands of genes that may be good candidates for the enhancement of bone healing and ivd and spinal cord regeneration. |
2002-11-06 |
2023-08-12 |
Not clear |