| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
af injury induced moderate ivd degeneration with acute and broad spinal inflammation that progressed to drg to sc changes within days and weeks, respectively. |
2024-02-10 |
2024-02-12 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
this study used an in vivo rat annulus fibrosus (af) injury-driven discogenic pain model to investigate the acute and chronic changes in ivd degeneration and spinal inflammation, as well as sensitization, inflammation, and remodeling in dorsal root ganglion (drg) and spinal cord (sc) dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
we conclude that af injury-driven ivd degeneration induces acute spinal, drg, and sc inflammatory crosstalk with sustained glial responses in both drgs and sc, leading to chronic sc sensitization and neural plasticity. |
2024-02-10 |
2024-02-12 |
rat |
| Miaoheng Yan, Zongmian Song, Hongwei Kou, Guowei Shang, Chunfeng Shang, Xiangrong Chen, Yanhui Ji, Deming Bao, Tian Cheng, Jinfeng Li, Xiao Lv, Hongjian Liu, Songfeng Che. New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain. Frontiers in cell and developmental biology. vol 10. 2022-06-07. PMID:35669508. |
lbp can be induced or exacerbated by abnormal structure and function of spinal tissue such as intervertebral disc (ivd), dorsal root ganglion (drg) and muscle; ivd degeneration (ivdd) is considered as the most important among all the pathogenic factors. |
2022-06-07 |
2023-08-14 |
Not clear |
| Joshua D Stover, Brandon Lawrence, Robby D Bowle. Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 6. 2021-09-02. PMID:32255531. |
in our model, rat dorsal root ganglia (drg) neurons were seeding onto bovine annulus fibrosus tissue, exposed to degenerative ivd conditioned media and/or acidic ph, and subjected to cyclic tensile strain (1 hz; 1%-6% strain) during measurement of drg sensory neuron activity via calcium imaging. |
2021-09-02 |
2023-08-13 |
rat |
| Xiaodong Huang, Changkun Zheng, Weiheng Wang, Xiaojian Ye, Chia-Ying Lin, Zenghui W. The Effect and Possible Mechanism of Intradiscal Injection of Simvastatin in the Treatment of Discogenic Pain in Rats. Frontiers in neuroscience. vol 15. 2021-04-06. PMID:33815046. |
the contents of nf-kappa b1, rela, gap43, sp, cgrp, trpm 8, il-1β, and tnf-α in the intervertebral disk (ivd), the corresponding contents of dorsal root ganglion (drg) and plantar skin gap43 and trpm 8 were quantitatively detected by pcr. |
2021-04-06 |
2023-08-13 |
rat |
| Grace E Mosley, Minghui Wang, Philip Nasser, Alon Lai, Daniel A Charen, Bin Zhang, James C Iatridi. Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32934258. |
females and males had distinct differences in mechanical allodynia and drg gene expression, even though sex differences in ivd measurements were limited. |
2020-12-15 |
2023-08-13 |
rat |
| Junxuan Ma, Despina Stefanoska, Sibylle Grad, Mauro Alini, Marianna Perogli. Direct and Intervertebral Disc-Mediated Sensitization of Dorsal Root Ganglion Neurons by Hypoxia and Low pH. Neurospine. vol 17. issue 1. 2020-09-28. PMID:32252154. |
ischemia-related risk factors are consistently correlated with discogenic pain, but it remains unclear how the ischemia-associated hypoxia and acidosis influence the peripheral sensory nervous system, namely the dorsal root ganglion (drg), either directly or indirectly via intervertebral disc (ivd) mediation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Junxuan Ma, Despina Stefanoska, Laura S Stone, Maria Hildebrand, Corrinus C van Donkelaar, Xuenong Zou, Valentina Basoli, Sibylle Grad, Mauro Alini, Marianna Perogli. Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth. JOR spine. vol 3. issue 2. 2020-09-28. PMID:32613165. |
results showed that hypoxia significantly increased neurite outgrowth length in nd7/23 cells, which was also validated in drg explant and primary cell culture, although hypoxia conditioned ivd did not significantly increase nd7/23 neurite outgrowth. |
2020-09-28 |
2023-08-13 |
rabbit |
| Joshua D Stover, Niloofar Farhang, Kristofer C Berrett, Jason Gertz, Brandon Lawrence, Robby D Bowle. CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 9. 2018-05-11. PMID:28676344. |
by exposing drg neurons to degenerative ivd-conditioned media under both normal and pathological ivd ph levels, we demonstrate that degenerative ivds trigger interleukin (il)-6-induced increases in neuron activity to thermal stimuli, which is directly mediated by akap and enhanced by acidic ph. |
2018-05-11 |
2023-08-13 |
Not clear |
| Takeshi Sainoh, Sumihisa Orita, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Kazuhide Inage, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Gen Inoue, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtor. Interleukin-6 and interleukin-6 receptor expression, localization, and involvement in pain-sensing neuron activation in a mouse intervertebral disc injury model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 10. 2015-11-25. PMID:26010074. |
il-6 and il-6r expression in the injured ivd were predominantly localized in the annulus fibrosus and endplate, and intradiscal injection of the il-6 inhibitor suppressed cgrp expression in the drg neurons. |
2015-11-25 |
2023-08-13 |
mouse |
| Devina Purmessur, Marisa C Cornejo, Samuel K Cho, Peter J Roughley, Robert J Linhardt, Andrew C Hecht, James C Iatridi. Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability. The spine journal : official journal of the North American Spine Society. vol 15. issue 5. 2015-11-20. PMID:25661435. |
the notochord produces factors during development that pattern the spine and inhibit the growth of dorsal root ganglion (drg) axons into the ivd. |
2015-11-20 |
2023-08-13 |
human |
| Sumihisa Orita, Seiji Ohtori, Maiko Nagata, Manato Horii, Masaomi Yamashita, Kazuyo Yamauchi, Gen Inoue, Munetaka Suzuki, Yawara Eguchi, Hiroto Kamoda, Gen Arai, Tetsuhiro Ishikawa, Masayuki Miyagi, Nobuyasu Ochiai, Shunji Kishida, Masashi Takaso, Yasuchika Aoki, Kazuhisa Takahash. Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 28. issue 12. 2010-11-15. PMID:20973063. |
to investigate the sensory innervation of injured rat lumbar intervertebral disc (ivd), we examined the expression of neuropeptides such as calcitonin gene-related peptide (cgrp) at dorsal root ganglia (drg) by inhibiting ngf or its dual receptors. |
2010-11-15 |
2023-08-12 |
rat |