| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caitlin Fenech, Bryony L Winters, Yo Otsu, Karin R Aubre. Supraspinal glycinergic neurotransmission in pain: A scoping review of current literature. Journal of neurochemistry. 2024-07-30. PMID:39075923. |
glycine's neurotransmitter roles have been most extensively investigated in the spinal cord, where it is known to play essential roles in pain, itch, and motor function. |
2024-07-30 |
2024-08-02 |
Not clear |
| Qi-Yu Chen, Min Zhu. Glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord. Molecular pain. 2023-01-06. PMID:36604775. |
recent studies using genetic deletion techniques have proposed that gastrin-releasing peptide (grp) is a key neurotransmitter for itch in the spinal cord. |
2023-01-06 |
2023-08-14 |
Not clear |
| Qi-Yu Chen, Min Zhu. Glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord. Molecular pain. 2023-01-06. PMID:36604775. |
glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord. |
2023-01-06 |
2023-08-14 |
Not clear |
| Qi-Yu Chen, Min Zhu. Glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord. Molecular pain. 2023-01-06. PMID:36604775. |
in this review, we review recent studies using different experimental approaches and propose that glutamate but not grp acts as the key neurotransmitter in the primary afferents in the transmission of itch. |
2023-01-06 |
2023-08-14 |
Not clear |
| Devin M Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao, Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, Zhou-Feng Che. Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors. Nature communications. vol 11. issue 1. 2020-07-13. PMID:32170060. |
gastrin-releasing peptide (grp) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. |
2020-07-13 |
2023-08-13 |
mouse |
| Benjamin U Hoffman, Yoshichika Baba, Theanne N Griffith, Eugene V Mosharov, Seung-Hyun Woo, Daniel D Roybal, Gerard Karsenty, Ardem Patapoutian, David Sulzer, Ellen A Lumpki. Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415995. |
epithelial-neuronal signaling is essential for sensory encoding in touch, itch, and nociception; however, little is known about the release mechanisms and neurotransmitter receptors through which skin cells govern neuronal excitability. |
2019-08-08 |
2023-08-13 |
mouse |
| Nazgol-Sadat Haddadi, Arash Foroutan, Saeed Shakiba, Khashayar Afshari, Sattar Ostadhadi, Maryam Daneshpazhooh, Ahmad-Reza Dehpou. Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids. Archives of dermatological research. vol 310. issue 2. 2018-09-18. PMID:29352328. |
serotonin (5-hydroxytryptamine or 5-ht) is a neurotransmitter in itch and impaired serotonin signaling has been linked to a variety of itch conditions. |
2018-09-18 |
2023-08-13 |
mouse |
| Carlos Solorzano, David Villafuerte, Karuna Meda, Ferda Cevikbas, Joao Bráz, Reza Sharif-Naeini, Dina Juarez-Salinas, Ida J Llewellyn-Smith, Zhonghui Guan, Allan I Basbau. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 2. 2015-04-07. PMID:25589759. |
there is continuing controversy relating to the primary afferent neurotransmitter that conveys itch signals to the spinal cord. |
2015-04-07 |
2023-08-13 |
mouse |
| Carlos Solorzano, David Villafuerte, Karuna Meda, Ferda Cevikbas, Joao Bráz, Reza Sharif-Naeini, Dina Juarez-Salinas, Ida J Llewellyn-Smith, Zhonghui Guan, Allan I Basbau. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 2. 2015-04-07. PMID:25589759. |
here, we investigated the drg and spinal cord expression of the putative primary afferent-derived "itch" neurotransmitter, gastrin-releasing peptide (grp). |
2015-04-07 |
2023-08-13 |
mouse |
| Xian-Yu Liu, Li Wan, Fu-Quan Huo, Devin M Barry, Hui Li, Zhong-Qiu Zhao, Zhou-Feng Che. B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Molecular pain. vol 10. 2014-09-28. PMID:24438367. |
to this end, they showed that grp mrna in drg neurons is either absent or barely detectable and claimed that bnp but not grp is a major neurotransmitter for itch in pruriceptors. |
2014-09-28 |
2023-08-12 |
mouse |
| Uta Funke, Danielle J Vugts, Bieneke Janssen, Arnold Spaans, Perry S Kruijer, Adriaan A Lammertsma, Lars R Perk, Albert D Windhors. (11) C-labeled and (18) F-labeled PET ligands for subtype-specific imaging of histamine receptors in the brain. Journal of labelled compounds & radiopharmaceuticals. vol 56. issue 3-4. 2014-07-16. PMID:24285318. |
in addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor and cognitive functions, as well as in itch and nociception. |
2014-07-16 |
2023-08-12 |
human |
| Michael S Fleming, Daniel Ramos, Seung Baek Han, Jianyuan Zhao, Young-Jin Son, Wenqin Lu. The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Molecular pain. vol 8. 2013-02-14. PMID:22776446. |
some recent findings have proposed that gastrin releasing peptide (grp) is expressed in a subset of dorsal root ganglion (drg) neurons and functions as a selective neurotransmitter for transferring itch information to spinal cord interneurons. |
2013-02-14 |
2023-08-12 |
Not clear |
| Ferda Cevikbas, Martin Steinhoff, Akihiko Ikom. Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS neuroscience & therapeutics. vol 17. issue 6. 2012-03-25. PMID:20950328. |
role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. |
2012-03-25 |
2023-08-12 |
Not clear |
| Kohei Koga, Tao Chen, Xiang-Yao Li, Giannina Descalzi, Jennifer Ling, Jianguo Gu, Min Zhu. Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Molecular pain. vol 7. 2011-09-12. PMID:21699733. |
recent studies have proposed that gastrin releasing peptide (grp) is a key neurotransmitter for itch in spinal cord. |
2011-09-12 |
2023-08-12 |
mouse |
| Necmettin Kirtak, H Serhat Inaloz, Cenk Akçali, Emin Erdal, Hasan Herken, Mehmet Yildirim, H Gulcin Erguve. Association of serotonin transporter gene-linked polymorphic region and variable number of tandem repeat polymorphism of the serotonin transporter gene in lichen simplex chronicus patients with psychiatric status. International journal of dermatology. vol 47. issue 10. 2009-03-31. PMID:18986359. |
the serotonin (5-hydroxytryptamine; 5-ht) is a key neurotransmitter in the central nervous system and a responsible mediator for the itch. |
2009-03-31 |
2023-08-12 |
Not clear |
| B Fjellner, O Hägermar. Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK-33-824, beta-endorphin and morphine. Archives of dermatological research. vol 274. issue 1-2. 1983-04-07. PMID:6187298. |
the effect of various opioid or putative neurotransmitter peptides on histamine-induced itch and flare responses was studied in humans after intradermal injection. |
1983-04-07 |
2023-08-12 |
human |