| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jagat Narayan Prajapati, Devanshi Piyush Shah, Arnab Bari. An intra-brainstem circuitry for pain-induced inhibition of itch. Neuroscience. 2025-01-08. PMID:39778623. |
interestingly, it has been observed that pain modulate itch through the neural circuits housed in the brain and spinal cord. |
2025-01-08 |
2025-01-13 |
mouse |
| Caitlin Fenech, Bryony L Winters, Yo Otsu, Karin R Aubre. Supraspinal glycinergic neurotransmission in pain: A scoping review of current literature. Journal of neurochemistry. 2024-07-30. PMID:39075923. |
glycine's neurotransmitter roles have been most extensively investigated in the spinal cord, where it is known to play essential roles in pain, itch, and motor function. |
2024-07-30 |
2024-08-02 |
Not clear |
| Ting-Ting Wang, Zi-Yang Li, Dan-Dan Hu, Xian-Yun Xu, Ning-Jing Song, Gang-Qiang Li, Ling Zhan. Spinal histamine H4 receptor mediates chronic pruritus via p-ERK in acetone-ether-water (AEW)-induced dry skin mice. Experimental dermatology. vol 33. issue 7. 2024-07-08. PMID:38973249. |
extracellular signal-regulated kinase (erk) phosphorylation activation in the spinal cord mediates histamine-induced acute and choric itch. |
2024-07-08 |
2024-07-11 |
mouse |
| Manuel P Pereira, Martin Met. [Neuropathy in pruritus medicine : Recommended diagnostics and therapy]. Dermatologie (Heidelberg, Germany). 2024-06-13. PMID:38869846. |
small-fiber neuropathy, nerve compression syndromes, post-herpetic neuralgia, scars and burns are possible conditions affecting the peripheral nervous system potentially causing itch, whereas space-occupying lesions affecting the spinal cord and stroke are examples of conditions that may induce central itch. |
2024-06-13 |
2024-06-15 |
Not clear |
| Andrew M Bell, Charlotte Utting, Allen C Dickie, Mateusz W Kucharczyk, Raphaëlle Quillet, Maria Gutierrez-Mecinas, Aimi N B Razlan, Andrew H Cooper, Yuxuan Lan, Junichi Hachisuka, Greg A Weir, Kirsty Bannister, Masahiko Watanabe, Artur Kania, Mark A Hoon, Iain C Macaulay, Franziska Denk, Andrew J Tod. Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 23. 2024-05-28. PMID:38805282. |
the anterolateral system (als) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch, and skin temperature. |
2024-05-28 |
2024-06-03 |
mouse |
| Jianyu Zhu, Yayue Yang, Lixia Du, Wei Yang, Yachen Yang, Ting Yi, Qiliang Maoying, Yuxia Chu, Yanqing Wang, Wenli M. A regulatory role of the medial septum in the chloroquine-induced acute itch through local GABAergic system and GABAergic pathway to the anterior cingulate cortex. Biochemical and biophysical research communications. vol 721. 2024-05-25. PMID:38795633. |
recent studies have unraveled the neural mechanisms of itch at peripheral, spinal cord as well as cerebral levels. |
2024-05-25 |
2024-05-31 |
Not clear |
| Huili Li, Weiwei Gao, Ze Zhang, Hao Chen, Yitong Wang, Liang D. Gastrin-Releasing Peptide/Gastrin-Releasing Peptide Receptor Participation in Itch Sensation Signaling in the Spinal Cord of Uremic Pruritus Mice. Alternative therapies in health and medicine. 2024-04-19. PMID:38639625. |
gastrin-releasing peptide/gastrin-releasing peptide receptor participation in itch sensation signaling in the spinal cord of uremic pruritus mice. |
2024-04-19 |
2024-04-21 |
mouse |
| Sihan Chen, Junhui Chen, Dan Tang, Wen Yin, Saihong Xu, Po Gao, Yingfu Jiao, Weifeng Y. Mechanical and Chemical Itch Regulated by Neuropeptide Y-Y1 Signaling. Molecular pain. 2024-03-14. PMID:38485252. |
these results indicate that npy neurons in spinal cord regulate mechanical and chemical itch, and alloknesis in dry skin model through npy1 receptors. |
2024-03-14 |
2024-03-17 |
Not clear |
| Jun-Feng Xu, Lian Liu, Yuan Liu, Ke-Xing Lu, Jun Zhang, Yan-Jing Zhu, Fang Fang, Yan-Nong Do. Spinal Nmur2-positive neurons play a crucial role in mechanical itch. The journal of pain. 2024-03-05. PMID:38442838. |
the dorsal spinal cord is crucial for the transmission and modulation of multiple somatosensory modalities, such as itch, pain, and touch. |
2024-03-05 |
2024-03-08 |
Not clear |
| Xuxing Pei, Bing Li, Xiaodong Xu, Hui Zhan. Spinal caspase-6 contributes to intrathecal morphine-induced acute itch and contact dermatitis-induced chronic itch through regulating the phosphorylation of protein kinase Mζ in mice. Neuroscience. 2024-01-04. PMID:38176610. |
neuroinflammation-mediated plasticity of sensory synapses in the spinal cord is critical for the development of pain and itch. |
2024-01-04 |
2024-01-07 |
mouse |
| Xinyi Gao, Yayue Yang, Jianyu Zhu, Yuxin Zhang, Chenghao Wang, Zhifei Wang, Wenli Mi, Lixia D. Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling. European journal of pharmacology. 2023-10-23. PMID:37871763. |
substantial progress has highlighted the crucial role of gastrin-releasing peptide (grp)-gastrin-releasing peptide receptor (grpr) signaling in the dorsal spinal cord in transmitting various types of itch. |
2023-10-23 |
2023-11-08 |
mouse |
| Zhe-Hao Xu, Jing-Cheng Zhang, Ke Chen, Xuan Liu, Xian-Zhi Li, Ming Yuan, Yue Wang, Jing-Yu Tia. Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. European journal of pharmacology. 2023-10-22. PMID:37866747. |
moreover, the pd-1 receptor was detected in the spinal cord of the mouse models of chronic itch that exhibited acetone, diethyl ether, and water (aew)-induced dry skin, imiquimod-induced psoriasis, and 1-fluoro-2,4-dinitrobenzene (dnfb)-induced allergic contact dermatitis. |
2023-10-22 |
2023-11-08 |
mouse |
| Andrew M Bell, Charlotte Utting, Allen C Dickie, Mateusz W Kucharczyk, Raphaëlle Quillet, Maria Gutierrez-Mecinas, Aimi N B Razlan, Andrew H Cooper, Yuxuan Lan, Junichi Hachisuka, Greg A Weir, Kirsty Bannister, Masahiko Watanabe, Artur Kania, Mark A Hoon, Iain C Macaulay, Franziska Denk, Andrew J Tod. Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons. bioRxiv : the preprint server for biology. 2023-10-03. PMID:37786726. |
the anterolateral system (als) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch and skin temperature. |
2023-10-03 |
2023-10-07 |
Not clear |
| Ayaka Haruta-Tsukamoto, Anna Kanemaru-Kawazoe, Yoichiro Kogoh, Yu Miyahara, Hideki Funahashi, Yoji Hirano, Toshikazu Nishimori, Yasushi Ishid. Role of kainate receptors in pruriceptive processing in the mouse spinal cord. European journal of pharmacology. 2023-08-19. PMID:37597648. |
these results indicate that ka receptors are involved in acute pruriceptive processing in the spinal cord induced by histamine, but not chloroquine or chronic itch. |
2023-08-19 |
2023-09-07 |
mouse |
| Tian-Chi Gao, Cheng-Hao Wang, Yan-Qing Wang, Wen-Li M. IL-33/ST2 signaling in the pathogenesis of chronic pain and itch. Neuroscience. 2023-08-13. PMID:37574108. |
evidence suggests that il-33 and its receptor st2 play a pivotal role in chronic pain and itch at the level of primary sensory neurons, the spinal cord, and the brain. |
2023-08-13 |
2023-08-16 |
Not clear |
| Sandeep Gupta, Eric Heinrichs, Bennett G Novitch, Samantha J Butle. Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546781. |
dorsal interneurons (dis) in the spinal cord encode the perception of touch, pain, heat, itch, and proprioception. |
2023-08-07 |
2023-08-14 |
mouse |
| Zhi-Jun Zhang, Han-Yu Shao, Chuan Liu, Hao-Lin Song, Xiao-Bo Wu, De-Li Cao, Meixuan Zhu, Yuan-Yuan Fu, Juan Wang, Yong-Jing Ga. Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR EMBO reports. 2023-07-31. PMID:37522391. |
descending dopaminergic pathway facilitates itch signal processing via activating spinal grpr a11 dopaminergic neurons regulate somatosensory transduction by projecting from the diencephalon to the spinal cord, but the function of this descending projection in itch remained elusive. |
2023-07-31 |
2023-08-14 |
Not clear |
| Keiko Takanami, Makoto Morishita, Tatsuya Sakamoto, Hirotaka Sakamot. Chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: relationship between the two distinct gastrin-releasing peptide systems in the spinal cord. General and comparative endocrinology. 2023-04-24. PMID:37094615. |
chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: relationship between the two distinct gastrin-releasing peptide systems in the spinal cord. |
2023-04-24 |
2023-08-14 |
rat |
| Keiko Takanami, Makoto Morishita, Tatsuya Sakamoto, Hirotaka Sakamot. Chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: relationship between the two distinct gastrin-releasing peptide systems in the spinal cord. General and comparative endocrinology. 2023-04-24. PMID:37094615. |
here, we examined the effects of chronic stress on itch sensation and male sexual function at the behavioral and molecular levels, focusing on two distinct gastrin-releasing peptide (grp) systems that independently regulate itch transmission, i.e., the somatosensory grp system, and male sexual function, i.e., the lumbosacral autonomic grp system, in the spinal cord. |
2023-04-24 |
2023-08-14 |
rat |
| Xiangyu Ren, Shijia Liu, Amandine Virlogeux, Sukjae J Kang, Jeremy Brusch, Yuanyuan Liu, Susan M Dymecki, Sung Han, Martyn Goulding, David Acto. Identification of an essential spinoparabrachial pathway for mechanical itch. Neuron. 2023-04-06. PMID:37023756. |
the neural pathways for itch transmission in the skin and spinal cord have been characterized previously, but the ascending pathways that transmit sensory information to the brain to evoke itch perception have not been identified. |
2023-04-06 |
2023-08-14 |
Not clear |