| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gyan Watson Ray, Qiaoli Zeng, Phidelia Kusi, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Runmin Gu. Genetic and inflammatory factors underlying gestational diabetes mellitus: a review. Frontiers in endocrinology. vol 15. 2024-05-02. PMID:38694942. |
this review delves into the pivotal role of insulin function and the influence of genetic variants, including slc30a8, cdkal1, tcf7l2, irs1, and gck, in gdm development. |
2024-05-02 |
2024-05-04 |
Not clear |
| Wanbao Yang, Wen Jiang, Wang Liao, Hui Yan, Weiqi Ai, Quan Pan, Wesley A Brashear, Yong Xu, Ling He, Shaodong Gu. An estrogen receptor α-derived peptide improves glucose homeostasis during obesity. Nature communications. vol 15. issue 1. 2024-04-22. PMID:38649684. |
mechanistic studies reveal that erα promotes hepatic insulin sensitivity by suppressing ubiquitination-induced irs1 degradation. |
2024-04-22 |
2024-04-26 |
mouse |
| Wanbao Yang, Wen Jiang, Wang Liao, Hui Yan, Weiqi Ai, Quan Pan, Wesley A Brashear, Yong Xu, Ling He, Shaodong Gu. An estrogen receptor α-derived peptide improves glucose homeostasis during obesity. Nature communications. vol 15. issue 1. 2024-04-22. PMID:38649684. |
furthermore, we identify a peptide based on erα 1-280 domain and find that erα-derived peptide increases irs1 stability and enhances insulin sensitivity. |
2024-04-22 |
2024-04-26 |
mouse |
| Ashok Daniel Prabakaran, Hyun-Jy Chung, Kevin McFarland, Thirupugal Govindarajan, Fadoua El Abdellaoui Soussi, Hima Bindu Durumutla, Chiara Villa, Kevin Piczer, Hannah Latimer, Cole Werbrich, Olukunle Akinborewa, Robert Horning, Mattia Quattrocell. The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585940. |
using adeno-associated viruses for in vivo overexpression in muscle, we found that foxc1 was sufficient to transcriptionally activate the insulin response pathway genes insr and irs1. |
2024-04-08 |
2024-04-10 |
mouse |
| Ritika Kumari Singh, Avinash Kumar Chaurasiya, Arvind Kuma. Ab initio modeling of human IRS1 protein to find novel target to dock with drug MH to mitigate T2DM diabetes by insulin signaling. 3 Biotech. vol 14. issue 4. 2024-03-13. PMID:38476643. |
ab initio modeling of human irs1 protein to find novel target to dock with drug mh to mitigate t2dm diabetes by insulin signaling. |
2024-03-13 |
2024-03-15 |
human |
| Quan Pan, Weiqi Ai, Shaodong Gu. TGF-β1 Signaling Impairs Metformin Action on Glycemic Control. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397103. |
in our hepatic insulin resistant mouse model (hepatic insulin receptor substrate 1 (irs1) and irs2 double knockout (dko)), metformin action on glycemic control was impaired, which is largely improved by further deletion of hepatic tgf-β1 (tkobeta1) or hepatic foxo1 (tkofoxo1). |
2024-02-24 |
2024-02-26 |
mouse |
| Jun Bum Park, Geon Ho Moon, Ara Cho, Minji Kwon, Jong-Wan Park, Eugene C Yi, Haeryoung Kim, Junji Fukuda, Cheol Kwak, Young-Gyu Ko, Yang-Sook Chu. Neddylation of insulin receptor substrate acts as a bona fide regulator of insulin signaling and its implications for cancer cell migration. Cancer gene therapy. 2024-01-25. PMID:38272982. |
altogether, these findings suggest that neddylation genuinely participates in irs1 and irs2-dependent insulin signaling, effectively suppressing cancer cell migration. |
2024-01-25 |
2024-01-28 |
Not clear |
| Haining Du, Jiaxin Li, Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Meimei Zhao, Ruijiao Zhu, Ziyi Zhang, Yuxia Zhang, Xiaoyan Li, Ning G. Methylparaben induces hepatic glycolipid metabolism disorder by activating the IRE1α-XBP1 signaling pathway in male mice. Environment international. vol 184. 2024-01-23. PMID:38262168. |
the activation of these pathways phosphorylated insulin receptor substrate-1 (irs1) (ser 307), resulting in decreased phosphorylation of protein kinase b (akt) (ser 473), leading to insulin resistance. |
2024-01-23 |
2024-01-26 |
mouse |
| Kumaran Sundaram, Yun Teng, Jingyao Mu, Qingbo Xu, Fangyi Xu, Mukesh K Sriwastva, Lifeng Zhang, Juw Won Park, Xiang Zhang, Jun Yan, Shuang Qin Zhang, Michael L Merchant, Shao-Yu Chen, Craig J McClain, Gerald W Dryden, Huang-Ge Zhan. Outer Membrane Vesicles Released from Garlic Exosome-like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut-Brain Axis. Small (Weinheim an der Bergstrasse, Germany). 2024-01-15. PMID:38225709. |
increasing the levels of phosphatidylcholines is required for inhibition of cgas and sting-mediated inflammation and glp-1r crosstalk with the insulin pathway that leads to increasing expression of insulin receptor substrate (irs1 and irs2) on omv targeted cells. |
2024-01-15 |
2024-01-18 |
mouse |
| Daewon Lee, Eunju Yoon, Su Jin Ham, Kunwoo Lee, Hansaem Jang, Daihn Woo, Da Hyun Lee, Sehyeon Kim, Sekyu Choi, Jongkyeong Chun. Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila. Nature communications. vol 15. issue 1. 2024-01-11. PMID:38212312. |
uchl1 governs insulin signaling by deubiquitinating insulin receptor substrate 1 (irs1) and antagonizes an e3 ligase of irs1, cullin 1 (cul1). |
2024-01-11 |
2024-01-14 |
drosophila_melanogaster |
| Aijun Tong, Zhiqun Li, Xiaoyan Liu, Xiaodong Ge, Runfan Zhao, Bin Liu, Lina Zhao, Chao Zha. Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis. International journal of biological macromolecules. 2023-12-22. PMID:38134985. |
real-time quantitative polymerase chain reaction assay suggested that ljo upregulated irs1 expression, consequently reducing insulin resistance. |
2023-12-22 |
2023-12-25 |
mouse |
| Yue Jiang, Li-Ke Yan, Ying Wang, Jun-Feng Ding, Zhong-Hua Xu, Can Cui, Jun T. [Mechanism of Gegen Qinlian Decoction in improving glucose metabolism in vitro and in vivo by alleviating hepatic endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114149. |
additionally, the phosphorylation levels of insulin receptor substrate 1(irs1), phosphatidylinositol 3-kinase regulatory subunit p85(pi3kp85), and protein kinase b(akt), which were involved in the insulin signaling pathway, were also measured. |
2023-12-19 |
2023-12-23 |
rat |
| Yufan Zhou, Tian Li, Zhijing He, Lavanya Choppavarapu, Xiaohui Hu, Ruifeng Cao, Gustavo W Leone, Michael Kahn, Victor X Ji. Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38013997. |
we finally elicit the deletion of a looping of irs1, a key insulin signaling gene, significantly impede pancreatic cancer cell growth, indicating that looping-mediated insulin signaling might act as an oncogenic pathway to promote pancreatic cancer progression. |
2023-11-28 |
2023-11-29 |
Not clear |
| Dinesh S Shah, Alison D McNeilly, Rory J McCrimmon, Harinder S Hunda. The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle. Cellular signalling. vol 113. 2023-11-02. PMID:37890688. |
this impairment in insulin signalling is associated with a three-fold elevation in intramyocellular diacylglycerol (dag) levels and a two-fold increase in cytosolic calcium content, which promote pkc-mediated irs1 inhibition via enhanced phosphorylation at irs1 ser1101. |
2023-11-02 |
2023-11-08 |
human |
| Laura Gence, Danielle Fernezelian, Olivier Meilhac, Sepand Rastegar, Jean-Loup Bascands, Nicolas Diote. Insulin signaling promotes neurogenesis in the brain of adult zebrafish. The Journal of comparative neurology. 2023-09-26. PMID:37750011. |
also, after a mechanical telencephalic stab-wound injury, we highlighted the overexpression of irs1 gene 5 days postlesion notably in the ventricular zone where radial glial cells (rgcs) are localized, suggesting key roles of insulin signaling in regenerative processes. |
2023-09-26 |
2023-10-07 |
zebrafish |
| Fatemeh Kazeminasab, Maryam Baharlooie, Hossein Rezazadeh, Nepton Soltani, Sara K Rosenkran. The effects of aerobic exercise on liver function, insulin resistance, and lipid profiles in prediabetic and type 2 diabetic mice. Physiology & behavior. 2023-08-30. PMID:37648184. |
the purpose of the current study was to evaluate the expression of gluconeogenesis and insulin resistance key genes; including insulin receptor substrate 1 (irs1), a serine/threonine protein kinase (akt), forkhead box class-o 1 (foxo1) and phosphoenolpyruvate carboxykinase (pepck) genes, and lipid profiles following either a standard or a high-fat diet (hfd) and either an aerobic exercise or non-exercise intervention in prediabetic and type 2 diabetic (t2dm) mice. |
2023-08-30 |
2023-09-07 |
mouse |
| Litao Zhang, Shuo Wang, Yimin Li, Boyu Liu, Zeyu Duan, Fei Liu, Qiang Re. Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-08-21. PMID:37604299. |
our previous study demonstrated that tartary buckwheat root polysaccharides (tbrp) could reduce insulin resistance in diabetes mellitus by inhibiting socs3-stimulated irs1 protein degradation. |
2023-08-21 |
2023-09-07 |
mouse |
| Emylle Costa-Bartuli, Adrielle Tenório Rodrigues, Sofia Andrade Ribeiro Bastos, Nathan Kistenmacker, Leticia Crepaldi, Christina Maeda Takiya, Patricia Zancan, Fabio Mendonça Gomes, Mauro Sola-Penn. The Role of Interferon Receptors α/β/γ Ablation During Western Diet-Induced Obesity and Insulin Resistance in the Inflectional Model AG129 Mice Strain. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2023-07-10. PMID:37428556. |
moreover, animals developed glucose and insulin intolerance, as well as dysregulation of insulin signaling mediators such as insulin receptor substrate 1 (irs1), protein kinase b (akt), and s6 ribosomal protein. |
2023-07-10 |
2023-08-14 |
mouse |
| Priyanshy Sharma, V Sri Swetha Victoria, P Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Redd. Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis. International immunopharmacology. vol 122. 2023-07-01. PMID:37392570. |
both ros and rns are associated with a reduction in irs1 phosphorylation in tyrosine, which leads to reduced levels of irs1 content and insulin response, which further leads to insulin resistance. |
2023-07-01 |
2023-08-14 |
Not clear |
| b' \\xc4\\x90ur\\xc4\\x91ica Ignjatovi\\xc4\\x87, Gordana Tovilovi\\xc4\\x87-Kova\\xc4\\x8devi\\xc4\\x87, Bojana Mi\\xc4\\x87i\\xc4\\x87, Mirko Tomi\\xc4\\x87, Ana Djordjevic, Djuro Macut, Danijela Vojnovi\\xc4\\x87 Milutinovi\\xc4\\x8. Effects of early life overnutrition and hyperandrogenism on spatial learning and memory in a rat model of polycystic ovary syndrome. Hormones and behavior. vol 153. 2023-06-09. PMID:37295324.' |
striatal insulin signaling was estimated by the levels of insulin receptor substrate 1 (irs1), its inhibitory phosphorylation at ser307, and glycogen synthase kinase-3α/β (gsk3α/β) activity. |
2023-06-09 |
2023-08-14 |
rat |