| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Hyun Lee, Ik-Rak Jung, Becky Tu-Sekine, Sunghee Jin, Frederick Anokye-Danso, Rexford S Ahima, Sangwon F Ki. Genetic Deletion of Skeletal Muscle Inositol Polyphosphate Multikinase Disrupts Glucose Homeostasis and Impairs Exercise Tolerance. bioRxiv : the preprint server for biology. 2024-08-12. PMID:39131310. |
furthermore, we have confirmed that a loss of ipmk led to reduced beta-oxidation, increased triglyceride accumulation, and impaired insulin response in ipmk-deficient muscle cells. |
2024-08-12 |
2024-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Time-Restricted Feeding Ameliorates Methionine-Choline Deficient Diet-Induced Steatohepatitis in Mice. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338668. |
we had previously reported that inositol polyphosphate multikinase (ipmk) mediates hepatic insulin signaling. |
2024-02-10 |
2024-02-12 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Time-restricted feeding ameliorates MCDD-induced steatohepatitis in mice. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014152. |
we had previously reported that inositol polyphosphate multikinase (ipmk) mediates hepatic insulin signaling. |
2023-11-28 |
2023-11-29 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes. Journal of cellular biochemistry. 2023-10-05. PMID:37795573. |
this study aimed to determine whether inositol polyphosphate multikinase (ipmk), a regulator of insulin signaling, plays any role in ffa-induced insulin resistance in primary hepatocytes. |
2023-10-05 |
2023-10-07 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes. Journal of cellular biochemistry. 2023-10-05. PMID:37795573. |
furthermore, treatment with the antioxidant n-acetyl cysteine (nac) significantly attenuated the ffa-induced reduction of ipmk and restored ffa-induced insulin resistance in pmh. |
2023-10-05 |
2023-10-07 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes. Journal of cellular biochemistry. 2023-10-05. PMID:37795573. |
our study highlights ipmk as a potential therapeutic target for preventing insulin resistance and nafld. |
2023-10-05 |
2023-10-07 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes. Journal of cellular biochemistry. 2023-10-05. PMID:37795573. |
moreover, overexpression of ipmk prevented the ffa-induced suppression of akt phosphorylation by insulin, while knockout of ipmk exacerbated insulin resistance in pmh. |
2023-10-05 |
2023-10-07 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes. Journal of cellular biochemistry. 2023-10-05. PMID:37795573. |
in conclusion, our findings suggest that excess ffa reduces ipmk expression and contributes to the ffa-induced decrease in akt phosphorylation in pmh, leading to insulin resistance. |
2023-10-05 |
2023-10-07 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
moreover, overexpression of ipmk prevented the ffa-induced suppression of akt phosphorylation by insulin, while knockout of ipmk exacerbated insulin resistance in pmh. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
in conclusion, our findings suggest that excess ffa reduces ipmk expression and contributes to the ffa-induced decrease in akt phosphorylation in pmh, leading to insulin resistance. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
ipmk modulates ffa-induced insulin resistance in primary mouse hepatocytes. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
furthermore, treatment with the antioxidant n-acetyl cysteine (nac) significantly attenuated the ffa-induced reduction of ipmk and restored ffa-induced insulin resistance in pmh. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
our study highlights ipmk as a potential therapeutic target for preventing insulin resistance and nafld. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Rexford S Ahima, Sangwon F Ki. IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162825. |
this study aimed to determine whether inositol polyphosphate multikinase (ipmk), a regulator of insulin signaling, plays any role in ffa-induced insulin resistance in primary hepatocytes. |
2023-05-10 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Frederick Anokye-Danso, Sunghee Jin, Rexford S Ahima, Sangwon F Ki. IPMK modulates hepatic glucose production and insulin signaling. Journal of cellular physiology. 2022-07-13. PMID:35822903. |
here, we show that inositol polyphosphate multikinase (ipmk), a key enzyme in inositol polyphosphate biosynthesis, plays a role in regulating hepatic insulin signaling and gluconeogenesis both in vitro and in vivo. |
2022-07-13 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Frederick Anokye-Danso, Sunghee Jin, Rexford S Ahima, Sangwon F Ki. IPMK modulates hepatic glucose production and insulin signaling. Journal of cellular physiology. 2022-07-13. PMID:35822903. |
moreover, hepatocyte-specific ipmk deletion exacerbates hyperglycemia and insulin sensitivity in mice fed a high-fat diet, accompanied by an increase in hgp during pyruvate tolerance test and reduction in akt phosphorylation in ipmk deficient liver. |
2022-07-13 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Frederick Anokye-Danso, Sunghee Jin, Rexford S Ahima, Sangwon F Ki. IPMK modulates hepatic glucose production and insulin signaling. Journal of cellular physiology. 2022-07-13. PMID:35822903. |
ipmk modulates hepatic glucose production and insulin signaling. |
2022-07-13 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Frederick Anokye-Danso, Sunghee Jin, Rexford S Ahima, Sangwon F Ki. IPMK modulates hepatic glucose production and insulin signaling. Journal of cellular physiology. 2022-07-13. PMID:35822903. |
importantly, re-expressing ipmk restores insulin sensitivity and alleviates glucose production in ipmk-deficient hepatocytes. |
2022-07-13 |
2023-08-14 |
mouse |
| Ik-Rak Jung, Frederick Anokye-Danso, Sunghee Jin, Rexford S Ahima, Sangwon F Ki. IPMK modulates hepatic glucose production and insulin signaling. Journal of cellular physiology. 2022-07-13. PMID:35822903. |
our results demonstrate that ipmk mediates insulin signaling and gluconeogenesis and may be potentially targeted for treatment of diabetes. |
2022-07-13 |
2023-08-14 |
mouse |